JPS57156467A - 2,4-disubstituted-6-quinazolinesulfonamide derivative - Google Patents
2,4-disubstituted-6-quinazolinesulfonamide derivativeInfo
- Publication number
- JPS57156467A JPS57156467A JP56039551A JP3955181A JPS57156467A JP S57156467 A JPS57156467 A JP S57156467A JP 56039551 A JP56039551 A JP 56039551A JP 3955181 A JP3955181 A JP 3955181A JP S57156467 A JPS57156467 A JP S57156467A
- Authority
- JP
- Japan
- Prior art keywords
- amino
- formula
- expressed
- compound expressed
- quinazolinesulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 2,4-disubstituted-6-quinazolinesulfonamide Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000002490 cerebral effect Effects 0.000 abstract 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- KOSZSUOVPAWNRE-UHFFFAOYSA-N 1-(2-ethoxy-2-phenylethyl)piperazine Chemical compound C=1C=CC=CC=1C(OCC)CN1CCNCC1 KOSZSUOVPAWNRE-UHFFFAOYSA-N 0.000 abstract 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- YPNGRZOYTLZRBD-UHFFFAOYSA-N 2-chloroquinazolin-4-amine Chemical compound C1=CC=C2C(N)=NC(Cl)=NC2=C1 YPNGRZOYTLZRBD-UHFFFAOYSA-N 0.000 abstract 1
- ODVIEEWNOYLISS-UHFFFAOYSA-N 4-amino-2-chloroquinazoline-6-sulfonyl chloride Chemical compound C1=C(S(Cl)(=O)=O)C=C2C(N)=NC(Cl)=NC2=C1 ODVIEEWNOYLISS-UHFFFAOYSA-N 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002040 relaxant effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002460 smooth muscle Anatomy 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56039551A JPS57156467A (en) | 1981-03-20 | 1981-03-20 | 2,4-disubstituted-6-quinazolinesulfonamide derivative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56039551A JPS57156467A (en) | 1981-03-20 | 1981-03-20 | 2,4-disubstituted-6-quinazolinesulfonamide derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57156467A true JPS57156467A (en) | 1982-09-27 |
| JPH0254344B2 JPH0254344B2 (enrdf_load_stackoverflow) | 1990-11-21 |
Family
ID=12556192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56039551A Granted JPS57156467A (en) | 1981-03-20 | 1981-03-20 | 2,4-disubstituted-6-quinazolinesulfonamide derivative |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS57156467A (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4502880A (en) * | 1983-02-03 | 1985-03-05 | E. I. Du Pont De Nemours And Company | 4-Pyridinium quinazoline derivatives |
| US4607034A (en) * | 1979-10-29 | 1986-08-19 | Mitsubishi Yuka Pharmaceutical Co., Ltd. | Quinazoline derivatives and pharmaceutical composition thereof |
| US5430148A (en) * | 1992-03-31 | 1995-07-04 | Agouron Pharmaceuticals, Inc. | Antiproliferative quinazolines |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5050390A (enrdf_load_stackoverflow) * | 1973-09-06 | 1975-05-06 | Ciba Geigy |
-
1981
- 1981-03-20 JP JP56039551A patent/JPS57156467A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5050390A (enrdf_load_stackoverflow) * | 1973-09-06 | 1975-05-06 | Ciba Geigy |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4607034A (en) * | 1979-10-29 | 1986-08-19 | Mitsubishi Yuka Pharmaceutical Co., Ltd. | Quinazoline derivatives and pharmaceutical composition thereof |
| US4502880A (en) * | 1983-02-03 | 1985-03-05 | E. I. Du Pont De Nemours And Company | 4-Pyridinium quinazoline derivatives |
| US5430148A (en) * | 1992-03-31 | 1995-07-04 | Agouron Pharmaceuticals, Inc. | Antiproliferative quinazolines |
| US5707992A (en) * | 1992-03-31 | 1998-01-13 | Agouron Pharmaceuticals, Inc. | Antiproliferative quinazolines |
| US5885996A (en) * | 1992-03-31 | 1999-03-23 | Agouron Pharmaceuticals, Inc. | Antiproliferative quinazolines |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0254344B2 (enrdf_load_stackoverflow) | 1990-11-21 |
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