JPS57150698A - Novel 1-(benzothiazol-2-yl)-4-diethoxy- or diisopropoxy- phosphinylbenzene - Google Patents

Novel 1-(benzothiazol-2-yl)-4-diethoxy- or diisopropoxy- phosphinylbenzene

Info

Publication number
JPS57150698A
JPS57150698A JP1252982A JP1252982A JPS57150698A JP S57150698 A JPS57150698 A JP S57150698A JP 1252982 A JP1252982 A JP 1252982A JP 1252982 A JP1252982 A JP 1252982A JP S57150698 A JPS57150698 A JP S57150698A
Authority
JP
Japan
Prior art keywords
benzothiazol
phosphinylbenzene
diisopropoxy
diethoxy
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1252982A
Other languages
Japanese (ja)
Other versions
JPS5851958B2 (en
Inventor
Goro Tsukamoto
Koichiro Yoshino
Tominori Morita
Hisashi Nose
Mitsuo Okazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Priority to JP1252982A priority Critical patent/JPS5851958B2/en
Publication of JPS57150698A publication Critical patent/JPS57150698A/en
Publication of JPS5851958B2 publication Critical patent/JPS5851958B2/en
Expired legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The compound of formulaI(R is ethyl or isopropyl).
EXAMPLE: 1-(Benzothiazol-2-yl)-4-diethoxyphosphinylmethylbenzene.
USE: It has calcium antagonistic activity and is useful as a preventive and remedy for ischemic cardiopathy such as stenocardia, cardiac infarction, arrhythmia, etc., and hypertension.
PROCESS: The compound of formulaIis prepared, e.g. by reacting 1-(benzothiazol- 2-yl)-4-bromomethylbenzene of formula II with preferably excess triethyl phosphite or triisopropyl phosphite of formula III, e.g. in the absence of solvent, under heating for 10W20min, preferably at 130W160°C.
COPYRIGHT: (C)1982,JPO&Japio
JP1252982A 1982-01-30 1982-01-30 Novel 1-(benzothiazol-2-yl)-4-diethoxy- or diisopropoxy-phosphinylbenzene Expired JPS5851958B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1252982A JPS5851958B2 (en) 1982-01-30 1982-01-30 Novel 1-(benzothiazol-2-yl)-4-diethoxy- or diisopropoxy-phosphinylbenzene

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1252982A JPS5851958B2 (en) 1982-01-30 1982-01-30 Novel 1-(benzothiazol-2-yl)-4-diethoxy- or diisopropoxy-phosphinylbenzene

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP1451779A Division JPS582929B2 (en) 1978-05-15 1979-02-08 Ischemic heart disease treatment or antihypertensive agent based on calcium anti-inflammatory action

Publications (2)

Publication Number Publication Date
JPS57150698A true JPS57150698A (en) 1982-09-17
JPS5851958B2 JPS5851958B2 (en) 1983-11-19

Family

ID=11807854

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1252982A Expired JPS5851958B2 (en) 1982-01-30 1982-01-30 Novel 1-(benzothiazol-2-yl)-4-diethoxy- or diisopropoxy-phosphinylbenzene

Country Status (1)

Country Link
JP (1) JPS5851958B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006051A1 (en) * 1993-08-20 1995-03-02 Otsuka Pharmaceutical Factory, Inc. Phosphonic diester derivative

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006051A1 (en) * 1993-08-20 1995-03-02 Otsuka Pharmaceutical Factory, Inc. Phosphonic diester derivative
US5527786A (en) * 1993-08-20 1996-06-18 Otsuka Pharmaceutical Factory, Inc. Phosphonic diester derivatives

Also Published As

Publication number Publication date
JPS5851958B2 (en) 1983-11-19

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