JPS57150698A - Novel 1-(benzothiazol-2-yl)-4-diethoxy- or diisopropoxy- phosphinylbenzene - Google Patents
Novel 1-(benzothiazol-2-yl)-4-diethoxy- or diisopropoxy- phosphinylbenzeneInfo
- Publication number
- JPS57150698A JPS57150698A JP1252982A JP1252982A JPS57150698A JP S57150698 A JPS57150698 A JP S57150698A JP 1252982 A JP1252982 A JP 1252982A JP 1252982 A JP1252982 A JP 1252982A JP S57150698 A JPS57150698 A JP S57150698A
- Authority
- JP
- Japan
- Prior art keywords
- benzothiazol
- phosphinylbenzene
- diisopropoxy
- diethoxy
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The compound of formulaI(R is ethyl or isopropyl).
EXAMPLE: 1-(Benzothiazol-2-yl)-4-diethoxyphosphinylmethylbenzene.
USE: It has calcium antagonistic activity and is useful as a preventive and remedy for ischemic cardiopathy such as stenocardia, cardiac infarction, arrhythmia, etc., and hypertension.
PROCESS: The compound of formulaIis prepared, e.g. by reacting 1-(benzothiazol- 2-yl)-4-bromomethylbenzene of formula II with preferably excess triethyl phosphite or triisopropyl phosphite of formula III, e.g. in the absence of solvent, under heating for 10W20min, preferably at 130W160°C.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1252982A JPS5851958B2 (en) | 1982-01-30 | 1982-01-30 | Novel 1-(benzothiazol-2-yl)-4-diethoxy- or diisopropoxy-phosphinylbenzene |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1252982A JPS5851958B2 (en) | 1982-01-30 | 1982-01-30 | Novel 1-(benzothiazol-2-yl)-4-diethoxy- or diisopropoxy-phosphinylbenzene |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1451779A Division JPS582929B2 (en) | 1978-05-15 | 1979-02-08 | Ischemic heart disease treatment or antihypertensive agent based on calcium anti-inflammatory action |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57150698A true JPS57150698A (en) | 1982-09-17 |
JPS5851958B2 JPS5851958B2 (en) | 1983-11-19 |
Family
ID=11807854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1252982A Expired JPS5851958B2 (en) | 1982-01-30 | 1982-01-30 | Novel 1-(benzothiazol-2-yl)-4-diethoxy- or diisopropoxy-phosphinylbenzene |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5851958B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995006051A1 (en) * | 1993-08-20 | 1995-03-02 | Otsuka Pharmaceutical Factory, Inc. | Phosphonic diester derivative |
-
1982
- 1982-01-30 JP JP1252982A patent/JPS5851958B2/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995006051A1 (en) * | 1993-08-20 | 1995-03-02 | Otsuka Pharmaceutical Factory, Inc. | Phosphonic diester derivative |
US5527786A (en) * | 1993-08-20 | 1996-06-18 | Otsuka Pharmaceutical Factory, Inc. | Phosphonic diester derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPS5851958B2 (en) | 1983-11-19 |
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