JPS57146721A - Improver for absorption - Google Patents

Improver for absorption

Info

Publication number
JPS57146721A
JPS57146721A JP3270581A JP3270581A JPS57146721A JP S57146721 A JPS57146721 A JP S57146721A JP 3270581 A JP3270581 A JP 3270581A JP 3270581 A JP3270581 A JP 3270581A JP S57146721 A JPS57146721 A JP S57146721A
Authority
JP
Japan
Prior art keywords
water
peptide derivative
drug
improver
absorption
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3270581A
Other languages
Japanese (ja)
Other versions
JPS634811B2 (en
Inventor
Kazuyoshi Nishiie
Renji Aikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyo Jozo KK
Original Assignee
Toyo Jozo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyo Jozo KK filed Critical Toyo Jozo KK
Priority to JP3270581A priority Critical patent/JPS57146721A/en
Priority to FR8203123A priority patent/FR2509175B1/en
Priority to CA000397097A priority patent/CA1188987A/en
Priority to DE19823207480 priority patent/DE3207480A1/en
Priority to GB8206489A priority patent/GB2095994B/en
Publication of JPS57146721A publication Critical patent/JPS57146721A/en
Publication of JPS634811B2 publication Critical patent/JPS634811B2/ja
Granted legal-status Critical Current

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  • Medicinal Preparation (AREA)

Abstract

PURPOSE: An improver for absorption of drug through membrane, comprising a water-soluble substance having a concentration exhibiting a higher tension than the osmotic pressure exhibited by the humor and an N-acrylated peptide derivative.
CONSTITUTION: An improver for absorption of a main drug, in the form of agent of ointment, cream, suppository, etc., comprising a water-soluble substance (e.g., water-soluble salt of alkali metal such as Na, K, or Li of halogenated salt, sulfate, phosphate, water-soluble saccharide such as sorbitol, etc.) having a concentration exhibiting higher tension than the osmotic pressure exhibited by the humor, and an N-acylated peptide derivative[a peptide derivative(peptide consists of two or more amino cids) which is N-acylated with ≥8C fatty acid such as caprylic acid, etc.]. The amount of the N-acylated peptide derivative is ≥0.01w/w% based on total amount. It is linked with a sodium, potassium, hydrochloride, etc. as a main drug to form a salt easily, and extremely useful for a drug exhibiting water solubility.
COPYRIGHT: (C)1982,JPO&Japio
JP3270581A 1981-03-06 1981-03-06 Improver for absorption Granted JPS57146721A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP3270581A JPS57146721A (en) 1981-03-06 1981-03-06 Improver for absorption
FR8203123A FR2509175B1 (en) 1981-03-06 1982-02-25 THERAPEUTIC PREPARATION HAVING EXCELLENT ABSORPTION PROPERTIES
CA000397097A CA1188987A (en) 1981-03-06 1982-02-25 Preparation having excellent absorption property
DE19823207480 DE3207480A1 (en) 1981-03-06 1982-03-02 PREPARATION WITH EXCELLENT ABSORPTION PROPERTIES
GB8206489A GB2095994B (en) 1981-03-06 1982-03-05 Preparations having excellent absorption property

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3270581A JPS57146721A (en) 1981-03-06 1981-03-06 Improver for absorption

Publications (2)

Publication Number Publication Date
JPS57146721A true JPS57146721A (en) 1982-09-10
JPS634811B2 JPS634811B2 (en) 1988-02-01

Family

ID=12366253

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3270581A Granted JPS57146721A (en) 1981-03-06 1981-03-06 Improver for absorption

Country Status (1)

Country Link
JP (1) JPS57146721A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006273875A (en) * 1993-04-22 2006-10-12 Emisphere Technolgies Inc Oral drug delivery composition and method therefor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006273875A (en) * 1993-04-22 2006-10-12 Emisphere Technolgies Inc Oral drug delivery composition and method therefor

Also Published As

Publication number Publication date
JPS634811B2 (en) 1988-02-01

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