JPS57146721A - Improver for absorption - Google Patents
Improver for absorptionInfo
- Publication number
- JPS57146721A JPS57146721A JP3270581A JP3270581A JPS57146721A JP S57146721 A JPS57146721 A JP S57146721A JP 3270581 A JP3270581 A JP 3270581A JP 3270581 A JP3270581 A JP 3270581A JP S57146721 A JPS57146721 A JP S57146721A
- Authority
- JP
- Japan
- Prior art keywords
- water
- peptide derivative
- drug
- improver
- absorption
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
PURPOSE: An improver for absorption of drug through membrane, comprising a water-soluble substance having a concentration exhibiting a higher tension than the osmotic pressure exhibited by the humor and an N-acrylated peptide derivative.
CONSTITUTION: An improver for absorption of a main drug, in the form of agent of ointment, cream, suppository, etc., comprising a water-soluble substance (e.g., water-soluble salt of alkali metal such as Na, K, or Li of halogenated salt, sulfate, phosphate, water-soluble saccharide such as sorbitol, etc.) having a concentration exhibiting higher tension than the osmotic pressure exhibited by the humor, and an N-acylated peptide derivative[a peptide derivative(peptide consists of two or more amino cids) which is N-acylated with ≥8C fatty acid such as caprylic acid, etc.]. The amount of the N-acylated peptide derivative is ≥0.01w/w% based on total amount. It is linked with a sodium, potassium, hydrochloride, etc. as a main drug to form a salt easily, and extremely useful for a drug exhibiting water solubility.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3270581A JPS57146721A (en) | 1981-03-06 | 1981-03-06 | Improver for absorption |
FR8203123A FR2509175B1 (en) | 1981-03-06 | 1982-02-25 | THERAPEUTIC PREPARATION HAVING EXCELLENT ABSORPTION PROPERTIES |
CA000397097A CA1188987A (en) | 1981-03-06 | 1982-02-25 | Preparation having excellent absorption property |
DE19823207480 DE3207480A1 (en) | 1981-03-06 | 1982-03-02 | PREPARATION WITH EXCELLENT ABSORPTION PROPERTIES |
GB8206489A GB2095994B (en) | 1981-03-06 | 1982-03-05 | Preparations having excellent absorption property |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3270581A JPS57146721A (en) | 1981-03-06 | 1981-03-06 | Improver for absorption |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57146721A true JPS57146721A (en) | 1982-09-10 |
JPS634811B2 JPS634811B2 (en) | 1988-02-01 |
Family
ID=12366253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3270581A Granted JPS57146721A (en) | 1981-03-06 | 1981-03-06 | Improver for absorption |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57146721A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006273875A (en) * | 1993-04-22 | 2006-10-12 | Emisphere Technolgies Inc | Oral drug delivery composition and method therefor |
-
1981
- 1981-03-06 JP JP3270581A patent/JPS57146721A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006273875A (en) * | 1993-04-22 | 2006-10-12 | Emisphere Technolgies Inc | Oral drug delivery composition and method therefor |
Also Published As
Publication number | Publication date |
---|---|
JPS634811B2 (en) | 1988-02-01 |
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