JPS57145846A - Preparation of tripeptide and its derivative - Google Patents

Preparation of tripeptide and its derivative

Info

Publication number
JPS57145846A
JPS57145846A JP56175909A JP17590981A JPS57145846A JP S57145846 A JPS57145846 A JP S57145846A JP 56175909 A JP56175909 A JP 56175909A JP 17590981 A JP17590981 A JP 17590981A JP S57145846 A JPS57145846 A JP S57145846A
Authority
JP
Japan
Prior art keywords
amino acid
partial peptide
tripeptide
benzoyl
pro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56175909A
Other languages
Japanese (ja)
Other versions
JPS5830300B2 (en
Inventor
Tadashi Takeuchi
Shigeru Sato
Kohei Umetsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP56175909A priority Critical patent/JPS5830300B2/en
Publication of JPS57145846A publication Critical patent/JPS57145846A/en
Publication of JPS5830300B2 publication Critical patent/JPS5830300B2/en
Expired legal-status Critical Current

Links

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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

NEW MATERIAL:The tripeptide of formulaI(A is H, benzoyl, 1-adamantanecarbonyl, or dansyl; Pro is L-Pro which is N-terminated amino acid residue; B is L-Leu, L-Phe, L-Met, L-Tyr, etc.; C is Gly or sarcosine; D is pyrrolidine).
EXAMPLE: The compound of formula II (Bz is benzoyl; Pyrr is 1-pyrrolidinyl).
USE: Agent for inhibiting the collagen synthesis. It is effective for the remedy of diseases caused by the over-accumulation of collagen, e.g. atherosclerosis, hepatocirrhosis, keloid, etc.
PROCESS: The compound of formulaIcan be prepared by condensing the corresponding amino acid or partial peptide with desired amino acid or partial peptide. The terminal group of the amino acid or partial peptide is activated and/or protected if necessary.
COPYRIGHT: (C)1982,JPO&Japio
JP56175909A 1981-11-02 1981-11-02 Method for producing tripeptides and their derivatives Expired JPS5830300B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56175909A JPS5830300B2 (en) 1981-11-02 1981-11-02 Method for producing tripeptides and their derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56175909A JPS5830300B2 (en) 1981-11-02 1981-11-02 Method for producing tripeptides and their derivatives

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP49082778A Division JPS5111761A (en) 1974-07-19 1974-07-19 Torioyobi tetorapepuchidonarabinisono judotaino seizoho

Publications (2)

Publication Number Publication Date
JPS57145846A true JPS57145846A (en) 1982-09-09
JPS5830300B2 JPS5830300B2 (en) 1983-06-28

Family

ID=16004354

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56175909A Expired JPS5830300B2 (en) 1981-11-02 1981-11-02 Method for producing tripeptides and their derivatives

Country Status (1)

Country Link
JP (1) JPS5830300B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760002A (en) * 1992-12-22 1998-06-02 The Proctor & Gamble Company Diflouro pentapeptide derivative anti-inflammatory agents
EP2407174A1 (en) * 2009-03-11 2012-01-18 Jellice Co., Ltd. Progression inhibitor or prophylactic agent for atherosclerosis, blood cholesterol level-lowering agent, and functional food or food for specified health uses

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760002A (en) * 1992-12-22 1998-06-02 The Proctor & Gamble Company Diflouro pentapeptide derivative anti-inflammatory agents
EP2407174A1 (en) * 2009-03-11 2012-01-18 Jellice Co., Ltd. Progression inhibitor or prophylactic agent for atherosclerosis, blood cholesterol level-lowering agent, and functional food or food for specified health uses
EP2407174A4 (en) * 2009-03-11 2012-11-28 Jellice Co Ltd Progression inhibitor or prophylactic agent for atherosclerosis, blood cholesterol level-lowering agent, and functional food or food for specified health uses
US9339524B2 (en) 2009-03-11 2016-05-17 Jellice Co., Ltd. Drug inhibiting the progression of atherosclerosis, preventive drug, blood cholesterol-lowering drug, functional food, and specific health food

Also Published As

Publication number Publication date
JPS5830300B2 (en) 1983-06-28

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