JPS57145846A - Preparation of tripeptide and its derivative - Google Patents
Preparation of tripeptide and its derivativeInfo
- Publication number
- JPS57145846A JPS57145846A JP56175909A JP17590981A JPS57145846A JP S57145846 A JPS57145846 A JP S57145846A JP 56175909 A JP56175909 A JP 56175909A JP 17590981 A JP17590981 A JP 17590981A JP S57145846 A JPS57145846 A JP S57145846A
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- partial peptide
- tripeptide
- benzoyl
- pro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
NEW MATERIAL:The tripeptide of formulaI(A is H, benzoyl, 1-adamantanecarbonyl, or dansyl; Pro is L-Pro which is N-terminated amino acid residue; B is L-Leu, L-Phe, L-Met, L-Tyr, etc.; C is Gly or sarcosine; D is pyrrolidine).
EXAMPLE: The compound of formula II (Bz is benzoyl; Pyrr is 1-pyrrolidinyl).
USE: Agent for inhibiting the collagen synthesis. It is effective for the remedy of diseases caused by the over-accumulation of collagen, e.g. atherosclerosis, hepatocirrhosis, keloid, etc.
PROCESS: The compound of formulaIcan be prepared by condensing the corresponding amino acid or partial peptide with desired amino acid or partial peptide. The terminal group of the amino acid or partial peptide is activated and/or protected if necessary.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56175909A JPS5830300B2 (en) | 1981-11-02 | 1981-11-02 | Method for producing tripeptides and their derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56175909A JPS5830300B2 (en) | 1981-11-02 | 1981-11-02 | Method for producing tripeptides and their derivatives |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP49082778A Division JPS5111761A (en) | 1974-07-19 | 1974-07-19 | Torioyobi tetorapepuchidonarabinisono judotaino seizoho |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57145846A true JPS57145846A (en) | 1982-09-09 |
JPS5830300B2 JPS5830300B2 (en) | 1983-06-28 |
Family
ID=16004354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56175909A Expired JPS5830300B2 (en) | 1981-11-02 | 1981-11-02 | Method for producing tripeptides and their derivatives |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5830300B2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5760002A (en) * | 1992-12-22 | 1998-06-02 | The Proctor & Gamble Company | Diflouro pentapeptide derivative anti-inflammatory agents |
EP2407174A1 (en) * | 2009-03-11 | 2012-01-18 | Jellice Co., Ltd. | Progression inhibitor or prophylactic agent for atherosclerosis, blood cholesterol level-lowering agent, and functional food or food for specified health uses |
-
1981
- 1981-11-02 JP JP56175909A patent/JPS5830300B2/en not_active Expired
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5760002A (en) * | 1992-12-22 | 1998-06-02 | The Proctor & Gamble Company | Diflouro pentapeptide derivative anti-inflammatory agents |
EP2407174A1 (en) * | 2009-03-11 | 2012-01-18 | Jellice Co., Ltd. | Progression inhibitor or prophylactic agent for atherosclerosis, blood cholesterol level-lowering agent, and functional food or food for specified health uses |
EP2407174A4 (en) * | 2009-03-11 | 2012-11-28 | Jellice Co Ltd | Progression inhibitor or prophylactic agent for atherosclerosis, blood cholesterol level-lowering agent, and functional food or food for specified health uses |
US9339524B2 (en) | 2009-03-11 | 2016-05-17 | Jellice Co., Ltd. | Drug inhibiting the progression of atherosclerosis, preventive drug, blood cholesterol-lowering drug, functional food, and specific health food |
Also Published As
Publication number | Publication date |
---|---|
JPS5830300B2 (en) | 1983-06-28 |
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