JPS5714560A - Novel cyclopentene derivative and its preparation - Google Patents
Novel cyclopentene derivative and its preparationInfo
- Publication number
- JPS5714560A JPS5714560A JP8790980A JP8790980A JPS5714560A JP S5714560 A JPS5714560 A JP S5714560A JP 8790980 A JP8790980 A JP 8790980A JP 8790980 A JP8790980 A JP 8790980A JP S5714560 A JPS5714560 A JP S5714560A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- preparation
- incorporate
- configuration
- hydroxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002433 cyclopentenyl group Chemical class C1(=CCCC1)* 0.000 title 1
- VQKFNUFAXTZWDK-UHFFFAOYSA-N 2-Methylfuran Chemical compound CC1=CC=CO1 VQKFNUFAXTZWDK-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 abstract 2
- -1 4-(o-Carboxylbenzoyloxy)-2-cyclopenten-1-one Chemical compound 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- LGRFSURHDFAFJT-UHFFFAOYSA-N Phthalic anhydride Natural products C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- JHIWVOJDXOSYLW-UHFFFAOYSA-N butyl 2,2-difluorocyclopropane-1-carboxylate Chemical compound CCCCOC(=O)C1CC1(F)F JHIWVOJDXOSYLW-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 239000008055 phosphate buffer solution Substances 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:Compounds of formula I (R is H, lower alkyl, aminium ion of optically active amine; X and Y incorporate to form oxo or one of them is H, the other is hydroxyl or protected hydroxyl; *shows that the carbon marked with* has S-configuration or R-configuration or their mixture in an arbitrary proportion).
EXAMPLE: 4-(o-Carboxylbenzoyloxy)-2-cyclopenten-1-one.
USE: Synthetic intermediate of prostaglandins.
PREPARATION: The reaction of dl-4-hydroxy-2-cyclopentn-1-one of formula II with phthalic anhydride of formula III is conducted in the presence of a base such as pyridine or colidine in a solvent such as carbon tetrachloride at -50W60°C to give the compound of formyla I where R is H, X and Y incorporate to form an oxo group. The starting material of formula II is obtained by brominating 2-methylfuran and treating the product with a phosphate buffer solution.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8790980A JPS5714560A (en) | 1980-06-30 | 1980-06-30 | Novel cyclopentene derivative and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8790980A JPS5714560A (en) | 1980-06-30 | 1980-06-30 | Novel cyclopentene derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5714560A true JPS5714560A (en) | 1982-01-25 |
| JPS632251B2 JPS632251B2 (en) | 1988-01-18 |
Family
ID=13928037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8790980A Granted JPS5714560A (en) | 1980-06-30 | 1980-06-30 | Novel cyclopentene derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5714560A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63167907U (en) * | 1987-04-21 | 1988-11-01 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53137932A (en) * | 1977-05-04 | 1978-12-01 | Kowa Co | Cyclopentene derivative and its preparation |
-
1980
- 1980-06-30 JP JP8790980A patent/JPS5714560A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53137932A (en) * | 1977-05-04 | 1978-12-01 | Kowa Co | Cyclopentene derivative and its preparation |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63167907U (en) * | 1987-04-21 | 1988-11-01 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS632251B2 (en) | 1988-01-18 |
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