JPS5711942A - Preparation of phenylmalonic acid momoester - Google Patents
Preparation of phenylmalonic acid momoesterInfo
- Publication number
- JPS5711942A JPS5711942A JP8514980A JP8514980A JPS5711942A JP S5711942 A JPS5711942 A JP S5711942A JP 8514980 A JP8514980 A JP 8514980A JP 8514980 A JP8514980 A JP 8514980A JP S5711942 A JPS5711942 A JP S5711942A
- Authority
- JP
- Japan
- Prior art keywords
- activator
- ester
- tetrahydropyranyloxy
- alkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To obtain the titled compound useful as an intermediate for various kinds of drugs industrially, by carbonilating a phenylacetic acid ester with CO2 using a specific activator as a more inexpensive raw material under mild reaction conditions.
CONSTITUTION: A phenylacetic ester, e.g., 4-(2-tetrahydropyranyloxy) phenylacetic acid 4'-methoxybenzyl ester, etc. shown by the formula I(R1 is H, OH, alkyl, alkoxy, heterocyclic oxy, etc.; R2 is alkyl, aralkyl, or aryl) is carboxylated with CO2 in the presence of an activator at -30°C, to give the desired compound, e.g., 2-[4-(2-tetrahydropyranyloxy) phenyl] malonic acid hydrogen 4-methoxybenzyl ester shown by the formula II, etc., an intermediate for preparing an antibiotic, e.g., penicillin, cephalosporin type, etc. A sodium compound of acetylene, cumene, triphenylmethane, etc. may be used as the activator.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8514980A JPS5711942A (en) | 1980-06-25 | 1980-06-25 | Preparation of phenylmalonic acid momoester |
US06/170,910 US4336196A (en) | 1979-07-27 | 1980-07-21 | Process for the production of phenylmalonic acid mono-esters |
ES493730A ES8106271A1 (en) | 1979-07-27 | 1980-07-24 | Process for the production of phenylmalonic acid mono-esters |
GB8024195A GB2056444B (en) | 1979-07-27 | 1980-07-24 | Process for the production of phenylmalonic acid mono-esters |
FR8016505A FR2462418A1 (en) | 1979-07-27 | 1980-07-25 | PROCESS FOR PRODUCING MONOESTERS OF PHENYLMALONIC ACID |
IT49348/80A IT1143026B (en) | 1979-07-27 | 1980-07-25 | PROCEDURE FOR THE PRODUCTION OF PHENYLMALONIC ACID MONOESTERS |
DE3028321A DE3028321C2 (en) | 1979-07-27 | 1980-07-25 | Process for the preparation of phenylmalonic acid monoesters |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8514980A JPS5711942A (en) | 1980-06-25 | 1980-06-25 | Preparation of phenylmalonic acid momoester |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5711942A true JPS5711942A (en) | 1982-01-21 |
JPS6248670B2 JPS6248670B2 (en) | 1987-10-15 |
Family
ID=13850602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8514980A Granted JPS5711942A (en) | 1979-07-27 | 1980-06-25 | Preparation of phenylmalonic acid momoester |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5711942A (en) |
-
1980
- 1980-06-25 JP JP8514980A patent/JPS5711942A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6248670B2 (en) | 1987-10-15 |
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