JPS5711942A - Preparation of phenylmalonic acid momoester - Google Patents

Preparation of phenylmalonic acid momoester

Info

Publication number
JPS5711942A
JPS5711942A JP8514980A JP8514980A JPS5711942A JP S5711942 A JPS5711942 A JP S5711942A JP 8514980 A JP8514980 A JP 8514980A JP 8514980 A JP8514980 A JP 8514980A JP S5711942 A JPS5711942 A JP S5711942A
Authority
JP
Japan
Prior art keywords
activator
ester
tetrahydropyranyloxy
alkyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8514980A
Other languages
Japanese (ja)
Other versions
JPS6248670B2 (en
Inventor
Shigeo Kitamura
Kazuo Yoshioka
Yoshiharu Seriyama
Hiroshi Suita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Soda Co Ltd
Shionogi and Co Ltd
Original Assignee
Nippon Soda Co Ltd
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Soda Co Ltd, Shionogi and Co Ltd filed Critical Nippon Soda Co Ltd
Priority to JP8514980A priority Critical patent/JPS5711942A/en
Priority to US06/170,910 priority patent/US4336196A/en
Priority to ES493730A priority patent/ES8106271A1/en
Priority to GB8024195A priority patent/GB2056444B/en
Priority to FR8016505A priority patent/FR2462418A1/en
Priority to IT49348/80A priority patent/IT1143026B/en
Priority to DE3028321A priority patent/DE3028321C2/en
Publication of JPS5711942A publication Critical patent/JPS5711942A/en
Publication of JPS6248670B2 publication Critical patent/JPS6248670B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the titled compound useful as an intermediate for various kinds of drugs industrially, by carbonilating a phenylacetic acid ester with CO2 using a specific activator as a more inexpensive raw material under mild reaction conditions.
CONSTITUTION: A phenylacetic ester, e.g., 4-(2-tetrahydropyranyloxy) phenylacetic acid 4'-methoxybenzyl ester, etc. shown by the formula I(R1 is H, OH, alkyl, alkoxy, heterocyclic oxy, etc.; R2 is alkyl, aralkyl, or aryl) is carboxylated with CO2 in the presence of an activator at -30°C, to give the desired compound, e.g., 2-[4-(2-tetrahydropyranyloxy) phenyl] malonic acid hydrogen 4-methoxybenzyl ester shown by the formula II, etc., an intermediate for preparing an antibiotic, e.g., penicillin, cephalosporin type, etc. A sodium compound of acetylene, cumene, triphenylmethane, etc. may be used as the activator.
COPYRIGHT: (C)1982,JPO&Japio
JP8514980A 1979-07-27 1980-06-25 Preparation of phenylmalonic acid momoester Granted JPS5711942A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP8514980A JPS5711942A (en) 1980-06-25 1980-06-25 Preparation of phenylmalonic acid momoester
US06/170,910 US4336196A (en) 1979-07-27 1980-07-21 Process for the production of phenylmalonic acid mono-esters
ES493730A ES8106271A1 (en) 1979-07-27 1980-07-24 Process for the production of phenylmalonic acid mono-esters
GB8024195A GB2056444B (en) 1979-07-27 1980-07-24 Process for the production of phenylmalonic acid mono-esters
FR8016505A FR2462418A1 (en) 1979-07-27 1980-07-25 PROCESS FOR PRODUCING MONOESTERS OF PHENYLMALONIC ACID
IT49348/80A IT1143026B (en) 1979-07-27 1980-07-25 PROCEDURE FOR THE PRODUCTION OF PHENYLMALONIC ACID MONOESTERS
DE3028321A DE3028321C2 (en) 1979-07-27 1980-07-25 Process for the preparation of phenylmalonic acid monoesters

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8514980A JPS5711942A (en) 1980-06-25 1980-06-25 Preparation of phenylmalonic acid momoester

Publications (2)

Publication Number Publication Date
JPS5711942A true JPS5711942A (en) 1982-01-21
JPS6248670B2 JPS6248670B2 (en) 1987-10-15

Family

ID=13850602

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8514980A Granted JPS5711942A (en) 1979-07-27 1980-06-25 Preparation of phenylmalonic acid momoester

Country Status (1)

Country Link
JP (1) JPS5711942A (en)

Also Published As

Publication number Publication date
JPS6248670B2 (en) 1987-10-15

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