JPS57106662A - Preparation of erythro 2-(4-benzylpiperidino)-1-(4- hydroxyphenyl)propanol - Google Patents

Preparation of erythro 2-(4-benzylpiperidino)-1-(4- hydroxyphenyl)propanol

Info

Publication number
JPS57106662A
JPS57106662A JP55182094A JP18209480A JPS57106662A JP S57106662 A JPS57106662 A JP S57106662A JP 55182094 A JP55182094 A JP 55182094A JP 18209480 A JP18209480 A JP 18209480A JP S57106662 A JPS57106662 A JP S57106662A
Authority
JP
Japan
Prior art keywords
diborane
hydroxyl group
erythro
hydroxyphenyl
propanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55182094A
Other languages
Japanese (ja)
Other versions
JPS6366313B2 (en
Inventor
Kazuo Kikazawa
Mineji Hiiragi
Nagatoshi Azuma
Toshitaka Kohagisawa
Hitoshi Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Grelan Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grelan Pharmaceutical Co Ltd filed Critical Grelan Pharmaceutical Co Ltd
Priority to JP55182094A priority Critical patent/JPS57106662A/en
Publication of JPS57106662A publication Critical patent/JPS57106662A/en
Publication of JPS6366313B2 publication Critical patent/JPS6366313B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Hydrogenated Pyridines (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as an improver for cerabral blood stream, etc. streoselectively easely and in high yield, by reducing a piperidinoalkanone having a phenolic hydroxyl group containing no protecting group with diborane directly.
CONSTITUTION: Piperidinoalkanone shown by the formulaIis reduced with diborane, to give erythro 2-(4-piperidino)-1-(hydroxyphenyl) propanol shown by the formula II. Since the compound shown by the formulaIis reduced diborane while the phenolic hydroxyl group is not being protected, the process to remove the hydroxyl group is omitted. An erythro form is obtained in high selectivity. Diborane is usually produced by reacting a solution of diboranetetrahydrofuran on the market or sodium boron hydride or lithium boron hydride with Lewis acid. and used.
COPYRIGHT: (C)1982,JPO&Japio
JP55182094A 1980-12-24 1980-12-24 Preparation of erythro 2-(4-benzylpiperidino)-1-(4- hydroxyphenyl)propanol Granted JPS57106662A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55182094A JPS57106662A (en) 1980-12-24 1980-12-24 Preparation of erythro 2-(4-benzylpiperidino)-1-(4- hydroxyphenyl)propanol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55182094A JPS57106662A (en) 1980-12-24 1980-12-24 Preparation of erythro 2-(4-benzylpiperidino)-1-(4- hydroxyphenyl)propanol

Publications (2)

Publication Number Publication Date
JPS57106662A true JPS57106662A (en) 1982-07-02
JPS6366313B2 JPS6366313B2 (en) 1988-12-20

Family

ID=16112240

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55182094A Granted JPS57106662A (en) 1980-12-24 1980-12-24 Preparation of erythro 2-(4-benzylpiperidino)-1-(4- hydroxyphenyl)propanol

Country Status (1)

Country Link
JP (1) JPS57106662A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5528903A (en) * 1978-08-18 1980-02-29 Grelan Pharmaceut Co Ltd Preparation of piperidinoalkanol

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5528903A (en) * 1978-08-18 1980-02-29 Grelan Pharmaceut Co Ltd Preparation of piperidinoalkanol

Also Published As

Publication number Publication date
JPS6366313B2 (en) 1988-12-20

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