JPS57106647A - Vitally influencing soft tertiary amine ester of carboxylic acid - Google Patents

Vitally influencing soft tertiary amine ester of carboxylic acid

Info

Publication number
JPS57106647A
JPS57106647A JP56173738A JP17373881A JPS57106647A JP S57106647 A JPS57106647 A JP S57106647A JP 56173738 A JP56173738 A JP 56173738A JP 17373881 A JP17373881 A JP 17373881A JP S57106647 A JPS57106647 A JP S57106647A
Authority
JP
Japan
Prior art keywords
vitally
carboxylic acid
tertiary amine
amine ester
influencing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56173738A
Other languages
English (en)
Japanese (ja)
Inventor
Bii Suroon Kenesu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS57106647A publication Critical patent/JPS57106647A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Indole Compounds (AREA)
JP56173738A 1980-10-31 1981-10-31 Vitally influencing soft tertiary amine ester of carboxylic acid Pending JPS57106647A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/202,750 US4381307A (en) 1980-10-31 1980-10-31 Soft tertiary amine esters of bio-affecting carboxylic acids

Publications (1)

Publication Number Publication Date
JPS57106647A true JPS57106647A (en) 1982-07-02

Family

ID=22751106

Family Applications (2)

Application Number Title Priority Date Filing Date
JP56173738A Pending JPS57106647A (en) 1980-10-31 1981-10-31 Vitally influencing soft tertiary amine ester of carboxylic acid
JP3006868A Pending JPH0733719A (ja) 1980-10-31 1991-01-24 生体影響力のあるカルボン酸のソフトな三級アミンエステル

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP3006868A Pending JPH0733719A (ja) 1980-10-31 1991-01-24 生体影響力のあるカルボン酸のソフトな三級アミンエステル

Country Status (8)

Country Link
US (1) US4381307A (US20090177143A1-20090709-C00008.png)
EP (1) EP0051278A1 (US20090177143A1-20090709-C00008.png)
JP (2) JPS57106647A (US20090177143A1-20090709-C00008.png)
DK (1) DK479581A (US20090177143A1-20090709-C00008.png)
ES (1) ES8302463A1 (US20090177143A1-20090709-C00008.png)
GR (1) GR75356B (US20090177143A1-20090709-C00008.png)
IE (1) IE53481B1 (US20090177143A1-20090709-C00008.png)
PT (1) PT73878B (US20090177143A1-20090709-C00008.png)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
USRE35053E (en) * 1985-09-12 1995-10-10 The Upjohn Company Amines useful in producing pharmaceutically active CNS compounds
US5099019A (en) * 1985-09-12 1992-03-24 Upjohn Company Amines useful in producing pharmaceutically active CNS compounds
US5382661A (en) * 1985-09-12 1995-01-17 The Upjohn Company Pyrazinylpiperazinyl steroids
US4863970A (en) * 1986-11-14 1989-09-05 Theratech, Inc. Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
US20030235877A1 (en) * 1996-04-30 2003-12-25 La Region Wallone Conjugates of haptens to beta-lactam derivatives and their use for detecting and/or quantifying haptens in solution and device for implementation thereof
JP2001507696A (ja) 1996-12-31 2001-06-12 アンチオキシダント ファーマシューティカルズ コーポレーション グルタチオンの医薬製剤およびその投与方法
US6896899B2 (en) * 1996-12-31 2005-05-24 Antioxidant Pharmaceuticals Corp. Pharmaceutical preparations of glutathione and methods of administration thereof
US7109326B2 (en) * 1997-04-15 2006-09-19 Genentech, Inc. Halo-alkoxycarbonyl prodrugs
US6762182B1 (en) 1999-01-07 2004-07-13 Vanderbilt University Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors
US6207700B1 (en) 1999-01-07 2001-03-27 Vanderbilt University Amide derivatives for antiangiogenic and/or antitumorigenic use
US6306890B1 (en) 1999-08-30 2001-10-23 Vanderbilt University Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
EP1744747A4 (en) 2004-04-26 2009-12-02 Univ Vanderbilt INDIC ACID AND INDULECTIC ACID DERIVATIVES AS THERAPEUTIC ACTIVITIES WITH REDUCED GASTROINTESTINAL TOXICITY
WO2007149456A2 (en) 2006-06-19 2007-12-27 Vanderbilt University Methods and compositions for diagnostic and therapeutic targeting of cox-2
WO2010039979A1 (en) * 2008-10-01 2010-04-08 Avedro, Inc. Eye therapy system
EP3078374B1 (en) 2011-10-17 2019-06-19 Vanderbilt University Indomethacin analogs for the treatment of castrate-resistant prostate cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1577931A (en) * 1977-02-11 1980-10-29 Beecham Group Ltd 6-methoxy -6-(2-carboxy-2-(4-hydroxyphenyl) acetamido penicillins
GB1604045A (en) * 1977-06-01 1981-12-02 Sterwin Ag -(2-methyl-indol-3-yl)-acetic acid esters processes for its prepartion and pharmaceutical compositions incorporating the same
CH601228A5 (en) * 1977-06-17 1978-06-30 Hisamitsu Pharmaceutical Co Antiinflammatory indomethacin esters active topically and orally
DE2732104A1 (de) * 1977-07-15 1979-01-25 Bayer Ag Penicilline, verfahren zu ihrer herstellung und ihre verwendung
IL56517A0 (en) * 1978-02-02 1979-03-12 American Cyanamid Co Novel 4-(cycloalkyl or cyclalkenyl substituted) amino, alkylamino or alkenylamino benzoic acids, salts and derivatives
US4241062A (en) * 1979-05-29 1980-12-23 Merck & Co., Inc. Antibacterial penicillins

Also Published As

Publication number Publication date
US4381307A (en) 1983-04-26
ES506537A0 (es) 1983-01-16
GR75356B (US20090177143A1-20090709-C00008.png) 1984-07-13
IE53481B1 (en) 1988-11-23
EP0051278A1 (en) 1982-05-12
PT73878A (en) 1981-11-01
JPH0733719A (ja) 1995-02-03
IE812523L (en) 1982-04-30
DK479581A (da) 1982-05-01
ES8302463A1 (es) 1983-01-16
PT73878B (en) 1983-12-19

Similar Documents

Publication Publication Date Title
JPS5716834A (en) Continuous manufacture of acetic acid ester
JPS57106647A (en) Vitally influencing soft tertiary amine ester of carboxylic acid
JPS5726645A (en) Manufacture of carbonic acid ester
JPS56167641A (en) Manufacture of carbonic acid ester
JPS57134438A (en) Manufacture of carboxylic acid
JPS5728020A (en) Manufacture of aromatic carboxylic acid
GB8425221D0 (en) Preparation of carboxylic acid esters
JPS5759831A (en) Manufacture of unsaturated carboxylic ester
GB2089804B (en) Preparation of carboxylic acid anhydrides
JPS5622744A (en) Manufacture of carboxylic acid
JPS56169660A (en) Manufacture of carboxylic acid amide
JPS5714552A (en) Manufacture of fatty carboxylic acid
JPS57200330A (en) Manufacture of carboxylic acid ester
JPS5728027A (en) Manufacture of aromatic carboxylic acid
JPS5742658A (en) Pentafluorobenzyl esters of phenylcycloalkane carboxylic acid
JPS57193469A (en) Manufacture of carboxylic acid ester of anhydrohexit
JPS5714553A (en) Manufacture of fatty carboxylic acid
JPS5646836A (en) Manufacture of aliphatic carboxylic acid
GB2080797B (en) Amides of p-isobutyl-phenylpropionic acid
JPS5714558A (en) Synthesis process of gamma-unsaturated carboxylic acid ester
GB8427816D0 (en) Esterification of carboxylic acid
JPS5721361A (en) Manufacture of nitronaphthalene-sulfonic acids
GB2091717B (en) Herbicidal esters of hydroxyalkanoic acids
GB2078724B (en) Carboxylic acid amides
JPS5770853A (en) Manufacture of carbamic acid ester