JPS5686186A - Oxabicycloheptane and hepteneprostaglandin analogue - Google Patents

Oxabicycloheptane and hepteneprostaglandin analogue

Info

Publication number
JPS5686186A
JPS5686186A JP15455880A JP15455880A JPS5686186A JP S5686186 A JPS5686186 A JP S5686186A JP 15455880 A JP15455880 A JP 15455880A JP 15455880 A JP15455880 A JP 15455880A JP S5686186 A JPS5686186 A JP S5686186A
Authority
JP
Japan
Prior art keywords
hepteneprostaglandin
oxabicycloheptane
analogue
hepteneprostaglandin analogue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15455880A
Other languages
English (en)
Japanese (ja)
Inventor
Daburiyuu Supureegu Peetaa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of JPS5686186A publication Critical patent/JPS5686186A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP15455880A 1979-11-01 1980-11-01 Oxabicycloheptane and hepteneprostaglandin analogue Pending JPS5686186A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/090,226 US4228180A (en) 1979-11-01 1979-11-01 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs

Publications (1)

Publication Number Publication Date
JPS5686186A true JPS5686186A (en) 1981-07-13

Family

ID=22221863

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15455880A Pending JPS5686186A (en) 1979-11-01 1980-11-01 Oxabicycloheptane and hepteneprostaglandin analogue

Country Status (6)

Country Link
US (1) US4228180A (OSRAM)
JP (1) JPS5686186A (OSRAM)
DE (1) DE3041114A1 (OSRAM)
FR (1) FR2468607A1 (OSRAM)
GB (1) GB2062629B (OSRAM)
IT (1) IT1134130B (OSRAM)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59122491A (ja) * 1982-12-27 1984-07-14 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド ７−オキサビシクロヘプタン置換アミノプロスタグランジン類縁体
JPS59134793A (ja) * 1983-01-12 1984-08-02 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド ７−オキサビシクロヘプタン置換アミノプロスタグランジン類縁体
JPS59137485A (ja) * 1983-01-21 1984-08-07 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテッド ７−オキサビシクロヘプタン置換カルバメ−トプロスタグランジン類縁体

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA814307B (en) * 1980-07-01 1983-02-23 Nat Res Dev Prostaglandins
US4360685A (en) * 1981-09-25 1982-11-23 E. R. Squibb & Sons, Inc. Dioxatricyclic prostacyclin analogs
US4420626A (en) * 1981-09-25 1983-12-13 E. R. Squibb & Sons, Inc. Dioxatricyclic prostacyclin analogs
US4537981A (en) * 1981-11-09 1985-08-27 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane and 7-oxabicycloheptene compounds
US4628061A (en) * 1981-12-23 1986-12-09 National Research Development Corporation Prostaglandins
US4418076A (en) * 1982-05-03 1983-11-29 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane hydrazone prostaglandin analogs useful in treating thrombolytic diseases
US4556675A (en) * 1982-05-17 1985-12-03 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane and 7-oxabicycloheptene compounds
US4537904A (en) * 1982-05-17 1985-08-27 E. R. Squibb & Sons, Inc. Compositions of 7-oxabicycloheptane and 7-oxabicycloheptene compounds and a method for their use in inhibiting bronchoconstriction
US4416896A (en) * 1982-05-17 1983-11-22 E. R. Squibb & Sons, Inc. 7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease
US4614825A (en) * 1982-05-17 1986-09-30 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane and 7-oxabicycloheptene compounds
US4463015A (en) * 1982-08-18 1984-07-31 E. R. Squibb & Sons, Inc. Aryl substituted 7-oxabicycloheptane compounds, useful in inhibiting platelet aggregation
US4456615A (en) * 1982-10-25 1984-06-26 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4474803A (en) * 1983-03-14 1984-10-02 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted thio prostaglandin analogs useful in treating platelet aggregation and bronchoconstriction
US4582854A (en) * 1983-03-14 1986-04-15 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted oxa prostaglandin analgos useful in the treatment of thrombolytic disease
US4474972A (en) * 1983-03-14 1984-10-02 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane prostaglandin intermediates and method for preparing same
CA1254577A (en) * 1983-05-13 1989-05-23 Peter W. Sprague 7-oxabicycloheptane prostaglandin intermediates and method for preparing same
US4525479A (en) * 1983-08-29 1985-06-25 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted thiocarbamate prostaglandin analogs useful as cardiovascular agents
US4474804A (en) * 1983-09-19 1984-10-02 E. R. Squibb & Sons, Inc. 7-Oxabicyclo substituted prostaglandin phenyl carboxylic acid derivatives useful as cardiovascular agents
US4522949A (en) * 1983-10-20 1985-06-11 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted prostaglandin interphenylene analogs useful as cardiovascular agents
US4513103A (en) * 1983-10-21 1985-04-23 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane ethers useful in the treatment of thrombolytic disease
US4524151A (en) * 1983-11-14 1985-06-18 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane thio ethers useful as cardiovascular agents
US4526901A (en) * 1984-01-26 1985-07-02 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted oxamide prostaglandin analogs and their use in treating thrombolytic disease
US4526900A (en) * 1984-01-26 1985-07-02 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease
US4536513A (en) * 1984-03-14 1985-08-20 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted prostaglandin interphenylene analogs useful in the treatment of thrombolytic disease
US4542155A (en) * 1984-04-02 1985-09-17 E. R. Squibb & Sons, Inc. Tetrahydrofuranyl substituted prostaglandin analogs
US4536514A (en) * 1984-04-06 1985-08-20 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombolytic disease
US4542156A (en) * 1984-04-26 1985-09-17 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted prostaglandin alcohols and their use in the treatment of thrombolytic disease
US4542157A (en) * 1984-04-27 1985-09-17 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease
US4550120A (en) * 1984-04-30 1985-10-29 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted ethers and their use in treating thrombolytic disease
US4521539A (en) * 1984-05-10 1985-06-04 E. R. Squibb & Sons, Inc. Tetrahydrofuranyl substituted ethers
US4542151A (en) * 1984-12-17 1985-09-17 E. R. Squibb & Sons, Inc. Tetrahydrothienyl substituted ethers
US4555523A (en) * 1984-06-04 1985-11-26 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted thio prostaglandin analogs and their use in the treatment of thrombolytic disease
US4560698A (en) * 1984-06-04 1985-12-24 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted thio prostaglandin analogs and their use in the treatment in thrombolytic disease
US4575512A (en) * 1984-11-01 1986-03-11 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their anti-thrombotic compositions and methods
US4661506A (en) * 1984-11-30 1987-04-28 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted ox prostaglandin analogs
US4654364A (en) * 1984-11-30 1987-03-31 E. R. Squibb & Sons, Inc. Hydroxamic acids of 7-oxabicycloheptane substituted ethers
US4638011A (en) * 1984-12-17 1987-01-20 E. R. Squibb & Sons, Inc. Tetrahydrothienyl substituted prostaglandin analogs
US4588743A (en) * 1985-01-22 1986-05-13 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane-substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease
US4588742A (en) * 1985-02-20 1986-05-13 E. R. Squibb & Sons, Inc. Thiabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disease
US4591603A (en) * 1985-02-25 1986-05-27 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disease
US4588741A (en) * 1985-02-28 1986-05-13 E. R. Squibb & Sons, Inc. Platelet aggregation inhibiting and bronchoconstriction inhibiting thiabicycloheptane substituted amino prostaglandin analog derivatives, compositions, and method of use therefor
US4611007A (en) * 1985-04-22 1986-09-09 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disease
US4607049A (en) * 1985-04-22 1986-08-19 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted thio prostaglandin analogs useful in the treatment of thrombolytic disease
US4608386A (en) * 1985-04-26 1986-08-26 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane ethers useful in the treatment of thrombotic diseases
US4607048A (en) * 1985-05-16 1986-08-19 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted aryl amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4595692A (en) * 1985-05-17 1986-06-17 E. R. Squibb & Sons, Inc. 7-thiabicycloheptane substituted ethers
US4611005A (en) * 1985-05-21 1986-09-09 E. R. Squibb & Sons, Inc. 5,6-epoxy-7-oxabicycloheptane substituted prostaglandin analogs useful in the treatment of thrombotic disease
US4609671A (en) * 1985-06-27 1986-09-02 E. R. Squibb & Sons, Inc. 5,6-epoxy-7-oxabicycloheptane substituted amino prostaglandin analogs useful in the treatment of thrombotic disease
US4611006A (en) * 1985-06-28 1986-09-09 E. R. Squibb & Sons, Inc. 5,6-epoxy-7-oxabicycloheptane substituted ethers useful in the treatment of thrombotic disease
US4663336A (en) * 1985-07-01 1987-05-05 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted diamide and its congener prostaglandin analogs useful in the treatment of thrombotic disease
US4654355A (en) * 1985-08-01 1987-03-31 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amide-thioamide prostaglandin analogs
US4654356A (en) * 1985-08-01 1987-03-31 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted diacid diamide prostaglandin analogs
US4654357A (en) * 1985-08-09 1987-03-31 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted sulfonamide prostaglandin analogs
US4632931A (en) * 1985-09-25 1986-12-30 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amide-sulfonamide prostaglandin analogs useful in the treatment of thrombotic disease
US4652576A (en) * 1985-10-18 1987-03-24 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amide-carbamate prostaglandin analogs
US4639461A (en) * 1985-10-28 1987-01-27 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted keto-amide prostaglandin analogs useful in the treatment of thrombotic disease
US4638012A (en) * 1985-11-05 1987-01-20 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane α-substituted ketone prostaglandin analogs useful in the treatment of thrombotic disease
US4647573A (en) * 1985-11-22 1987-03-03 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted thioamide-amide prostaglandin analogs
US4656185A (en) * 1985-12-05 1987-04-07 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted aminoalkyl amide prostaglandin analogs
US4654367A (en) * 1986-02-14 1987-03-31 E. R. Squibb & Sons, Inc. Hydroxamic acids of 7-oxabicycloheptane substituted ethers useful as anti-allergy and anti-inflammation agents
US4654366A (en) * 1986-02-14 1987-03-31 E. R. Squibb & Sons, Inc. Hydroxamic acids of 7-oxabicyclo[2.2.1]heptane substituted ethers useful as anti-thrombotic agents
US4663337A (en) * 1986-04-18 1987-05-05 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amides useful in the treatment of thrombotic disease
US4670453A (en) * 1986-05-08 1987-06-02 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amido-carbamoyl prostaglandin analogs useful in the treatment of thrombotic disease
US4687865A (en) * 1986-06-04 1987-08-18 E. R. Squibb & Sons, Inc. Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists
US4851553A (en) * 1986-06-04 1989-07-25 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane amido-carboxylic acids
US4958036A (en) * 1986-06-04 1990-09-18 E. R. Squibb & Sons, Inc. Enantiomerically selective synthesis of certain N-substituted-2-(carbamyl 7-oxabicyclo[2.2.1]heptane-3-carboxylic acids
US4816579A (en) * 1986-06-04 1989-03-28 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists
US4743697A (en) * 1986-06-04 1988-05-10 E. R. Squibb & Sons, Inc. Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists and novel intermediates procuced therein
US4673685A (en) * 1986-07-23 1987-06-16 E. R. Squibb & Sons, Inc. Hydroximic acids of 7-oxabicycloheptane substituted ethers and thioethers useful in the treatment of thrombotic disease
US4672075A (en) * 1986-08-26 1987-06-09 E. R. Squibb & Sons 7-Oxabicyclo(2.2.1)heptane hydroxamic acid derivatives useful as antiinflammatory, antiasthma and antipsoriatic agents
US4707494A (en) * 1986-08-26 1987-11-17 E. R. Squibb & Sons, Inc. 7-oxabicyclo(2.2.1)heptane compounds useful in the treatment of inflammation
US4734426A (en) * 1986-09-24 1988-03-29 E. R. Squibb & Sons, Inc. 5,6-epoxy-7-oxabicycloheptane substituted diamide prostaglandin analogs
US4734424A (en) * 1986-09-24 1988-03-29 E. R. Squibb & Sons, Inc. Bicycloheptane substituted diamide and its congener prostaglandin analogs
US4735962A (en) * 1986-10-06 1988-04-05 E. R. Squibb & Sons, Inc. 7-thiabicycloheptane substituted diamide and its congener prostaglandin analogs
US4734425A (en) * 1986-10-17 1988-03-29 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted hydroxamic acid prostaglandin analogs
US4738978A (en) * 1986-11-10 1988-04-19 E. R. Squibb & Sons, Inc. Bisthioamide-7-oxabicycloheptane prostaglandin analogs
US4749715A (en) * 1987-03-02 1988-06-07 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amino prostaglandin analogs
AUPP466598A0 (en) * 1998-07-14 1998-08-06 University Of Newcastle Research Associates Limited, The Product and process
AUPR392301A0 (en) * 2001-03-23 2001-04-26 University Of Newcastle Research Associates Limited, The Protein phosphatase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4112224A (en) * 1976-08-16 1978-09-05 The Upjohn Company Biheterocyclic-9,11-trideoxy-PGF compounds
US4143054A (en) * 1977-11-04 1979-03-06 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane- and 7-oxabicycloheptene compounds

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59122491A (ja) * 1982-12-27 1984-07-14 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド ７−オキサビシクロヘプタン置換アミノプロスタグランジン類縁体
JPS59134793A (ja) * 1983-01-12 1984-08-02 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド ７−オキサビシクロヘプタン置換アミノプロスタグランジン類縁体
JPS59137485A (ja) * 1983-01-21 1984-08-07 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテッド ７−オキサビシクロヘプタン置換カルバメ−トプロスタグランジン類縁体

Also Published As

Publication number Publication date
GB2062629B (en) 1984-03-21
IT1134130B (it) 1986-07-24
FR2468607B1 (OSRAM) 1983-09-30
US4228180A (en) 1980-10-14
GB2062629A (en) 1981-05-28
IT8025713A0 (it) 1980-10-31
DE3041114A1 (de) 1981-05-14
FR2468607A1 (fr) 1981-05-08

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