JPS5683455A - Preparation of dl-serine - Google Patents
Preparation of dl-serineInfo
- Publication number
- JPS5683455A JPS5683455A JP16035079A JP16035079A JPS5683455A JP S5683455 A JPS5683455 A JP S5683455A JP 16035079 A JP16035079 A JP 16035079A JP 16035079 A JP16035079 A JP 16035079A JP S5683455 A JPS5683455 A JP S5683455A
- Authority
- JP
- Japan
- Prior art keywords
- serine
- resin
- water
- aminopropionitrile
- halogeno
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled compound in a short step and in high yield, by passing a reaction solution of an α-halogeno-β-aminopropionitrile which is easily prepared with NaOH through a strongly acidic cation exchange resin, removing halogen with water, and heating the resin.
CONSTITUTION: An α-halogeno-β-aminopropionitrile or a mineral acid salt thereof is treated with an alkali (earth) metal hydroxide in water or a hydrous organic solvent, to form an alkali (earth) metal salt of aziridine-2-carboxylic acid. The resultant reaction solution is then passed through a strongly acidic cation exchange resin to adsorb the aziridine-2-carboxylic acid on the resin. Halogen ions are then removed by washing with water, and the wet resin is ted preferably at 50W100°C to give DL-serine.
USE: L-serine is useful as an amino acid transfusion, and D-serine is useful as a raw material for antibiotic cycloserine.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16035079A JPS5683455A (en) | 1979-12-12 | 1979-12-12 | Preparation of dl-serine |
US06/212,102 US4304933A (en) | 1979-12-10 | 1980-12-02 | Production of DL-serine |
EP80304440A EP0030475B1 (en) | 1979-12-10 | 1980-12-09 | Process for producing solutions of aziridine-2-carboxylic acid salts |
DE8080304439T DE3061695D1 (en) | 1979-12-10 | 1980-12-09 | Process for the production of dl-serines |
MX10181780U MX7073E (en) | 1979-12-10 | 1980-12-09 | IMPROVED PROCEDURE FOR PRODUCING DL-SERINA |
EP19800304439 EP0030474B1 (en) | 1979-12-10 | 1980-12-09 | Process for the production of dl-serines |
CA000366383A CA1145359A (en) | 1979-12-10 | 1980-12-09 | Production of dl-serine |
DE8080304440T DE3067054D1 (en) | 1979-12-10 | 1980-12-09 | Process for producing solutions of aziridine-2-carboxylic acid salts |
AU65263/80A AU542947B2 (en) | 1979-12-10 | 1980-12-10 | D-l serine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16035079A JPS5683455A (en) | 1979-12-12 | 1979-12-12 | Preparation of dl-serine |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5683455A true JPS5683455A (en) | 1981-07-08 |
JPS6320813B2 JPS6320813B2 (en) | 1988-04-30 |
Family
ID=15713072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16035079A Granted JPS5683455A (en) | 1979-12-10 | 1979-12-12 | Preparation of dl-serine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5683455A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54159250A (en) * | 1978-06-07 | 1979-12-15 | Motoyoshi Kanasugi | Water content sensing telemeter system |
-
1979
- 1979-12-12 JP JP16035079A patent/JPS5683455A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54159250A (en) * | 1978-06-07 | 1979-12-15 | Motoyoshi Kanasugi | Water content sensing telemeter system |
Also Published As
Publication number | Publication date |
---|---|
JPS6320813B2 (en) | 1988-04-30 |
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