JPS5683455A - Preparation of dl-serine - Google Patents

Preparation of dl-serine

Info

Publication number
JPS5683455A
JPS5683455A JP16035079A JP16035079A JPS5683455A JP S5683455 A JPS5683455 A JP S5683455A JP 16035079 A JP16035079 A JP 16035079A JP 16035079 A JP16035079 A JP 16035079A JP S5683455 A JPS5683455 A JP S5683455A
Authority
JP
Japan
Prior art keywords
serine
resin
water
aminopropionitrile
halogeno
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16035079A
Other languages
Japanese (ja)
Other versions
JPS6320813B2 (en
Inventor
Ryuichi Mita
Chojiro Higuchi
Toshio Kato
Nobuyuki Kawashima
Teruhiro Yamaguchi
Shosuke Nagai
Takao Takano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Priority to JP16035079A priority Critical patent/JPS5683455A/en
Priority to US06/212,102 priority patent/US4304933A/en
Priority to MX10181780U priority patent/MX7073E/en
Priority to DE8080304440T priority patent/DE3067054D1/en
Priority to EP80304440A priority patent/EP0030475B1/en
Priority to DE8080304439T priority patent/DE3061695D1/en
Priority to EP19800304439 priority patent/EP0030474B1/en
Priority to CA000366383A priority patent/CA1145359A/en
Priority to AU65263/80A priority patent/AU542947B2/en
Publication of JPS5683455A publication Critical patent/JPS5683455A/en
Publication of JPS6320813B2 publication Critical patent/JPS6320813B2/ja
Granted legal-status Critical Current

Links

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled compound in a short step and in high yield, by passing a reaction solution of an α-halogeno-β-aminopropionitrile which is easily prepared with NaOH through a strongly acidic cation exchange resin, removing halogen with water, and heating the resin.
CONSTITUTION: An α-halogeno-β-aminopropionitrile or a mineral acid salt thereof is treated with an alkali (earth) metal hydroxide in water or a hydrous organic solvent, to form an alkali (earth) metal salt of aziridine-2-carboxylic acid. The resultant reaction solution is then passed through a strongly acidic cation exchange resin to adsorb the aziridine-2-carboxylic acid on the resin. Halogen ions are then removed by washing with water, and the wet resin is ted preferably at 50W100°C to give DL-serine.
USE: L-serine is useful as an amino acid transfusion, and D-serine is useful as a raw material for antibiotic cycloserine.
COPYRIGHT: (C)1981,JPO&Japio
JP16035079A 1979-12-10 1979-12-12 Preparation of dl-serine Granted JPS5683455A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP16035079A JPS5683455A (en) 1979-12-12 1979-12-12 Preparation of dl-serine
US06/212,102 US4304933A (en) 1979-12-10 1980-12-02 Production of DL-serine
MX10181780U MX7073E (en) 1979-12-10 1980-12-09 IMPROVED PROCEDURE FOR PRODUCING DL-SERINA
DE8080304440T DE3067054D1 (en) 1979-12-10 1980-12-09 Process for producing solutions of aziridine-2-carboxylic acid salts
EP80304440A EP0030475B1 (en) 1979-12-10 1980-12-09 Process for producing solutions of aziridine-2-carboxylic acid salts
DE8080304439T DE3061695D1 (en) 1979-12-10 1980-12-09 Process for the production of dl-serines
EP19800304439 EP0030474B1 (en) 1979-12-10 1980-12-09 Process for the production of dl-serines
CA000366383A CA1145359A (en) 1979-12-10 1980-12-09 Production of dl-serine
AU65263/80A AU542947B2 (en) 1979-12-10 1980-12-10 D-l serine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16035079A JPS5683455A (en) 1979-12-12 1979-12-12 Preparation of dl-serine

Publications (2)

Publication Number Publication Date
JPS5683455A true JPS5683455A (en) 1981-07-08
JPS6320813B2 JPS6320813B2 (en) 1988-04-30

Family

ID=15713072

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16035079A Granted JPS5683455A (en) 1979-12-10 1979-12-12 Preparation of dl-serine

Country Status (1)

Country Link
JP (1) JPS5683455A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54159250A (en) * 1978-06-07 1979-12-15 Motoyoshi Kanasugi Water content sensing telemeter system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54159250A (en) * 1978-06-07 1979-12-15 Motoyoshi Kanasugi Water content sensing telemeter system

Also Published As

Publication number Publication date
JPS6320813B2 (en) 1988-04-30

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