JPS5677257A - Drug having beta-blocking activity - Google Patents
Drug having beta-blocking activityInfo
- Publication number
- JPS5677257A JPS5677257A JP15519779A JP15519779A JPS5677257A JP S5677257 A JPS5677257 A JP S5677257A JP 15519779 A JP15519779 A JP 15519779A JP 15519779 A JP15519779 A JP 15519779A JP S5677257 A JPS5677257 A JP S5677257A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- blocking activity
- propanol
- active component
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To provide a low-toxic drug having β-blocking activity, and containing 1-(indolin-4-yloxy)-3-(isopropylamino)-2-propanol as an active component.
CONSTITUTION: A drug having β-blocking activity can be prepared by using 1- (indolin-4-yloxy)-3-(isopropylamino)-2-propanol as an active component. The active component is a novel compound synthesized and filed before by the applicant, and obtained by (1) heating N-benzyl-4-methoxyindoline with hydrobromic acid under reflux, (2) neutralizing the reaction product with NaOH, and extracting with benzene, (3) concentrating the extract to obtain N-benzy-4-hydroxyindoline, and (4) reacting the compound thus obtained with NaOH solution and 1-(N-benzyl- isopropylamine)-3-chloro-2-propanol.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15519779A JPS5677257A (en) | 1979-11-29 | 1979-11-29 | Drug having beta-blocking activity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15519779A JPS5677257A (en) | 1979-11-29 | 1979-11-29 | Drug having beta-blocking activity |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5677257A true JPS5677257A (en) | 1981-06-25 |
Family
ID=15600612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15519779A Pending JPS5677257A (en) | 1979-11-29 | 1979-11-29 | Drug having beta-blocking activity |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5677257A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4863949A (en) * | 1985-04-06 | 1989-09-05 | Boehringer Mannheim Gmbh | Aminopropanol derivatives, processes for the preparation thereof, the use thereof and pharmaceutical compositions containing them |
-
1979
- 1979-11-29 JP JP15519779A patent/JPS5677257A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4863949A (en) * | 1985-04-06 | 1989-09-05 | Boehringer Mannheim Gmbh | Aminopropanol derivatives, processes for the preparation thereof, the use thereof and pharmaceutical compositions containing them |
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