JPS5665829A - Antitumor agent - Google Patents
Antitumor agentInfo
- Publication number
- JPS5665829A JPS5665829A JP14215379A JP14215379A JPS5665829A JP S5665829 A JPS5665829 A JP S5665829A JP 14215379 A JP14215379 A JP 14215379A JP 14215379 A JP14215379 A JP 14215379A JP S5665829 A JPS5665829 A JP S5665829A
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antitumor
- purity
- tumor
- purified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A substance obtained by subjecting a high-purity antibody to a tumor antigen, prepared by purification through affinity chromatography, and an antitumor antimetabolite having at least one amino or carboxyl group to amide bonding.
EXAMPLE: An amide bond substance of a high-purity immunoglobulin induced from an antigen of human cancer, e.g., sarcoma 180, Sato's lung cancer, leukemia L-1210, Ehrlich cancer, etc. and purified, and cytarabine, 8-azaguanine, 5-fluorouracil, etc.
USE: An antitumor agent. Since the agent is bonded to a high-purity antibody to a tumor antigen, it can be transferred efficiently to tumor parts of the body, and it can exhibit an antitumor effect selectively. Consequently, side effects to the normal cell occur slightly.
PROCESS: A tumor cell is injected hypodermically to an animal, which is immunized to give an antibody which is purified. The highly purified antibody and an antitumor antimetabolite are subjected to amide bonding.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14215379A JPS5665829A (en) | 1979-11-02 | 1979-11-02 | Antitumor agent |
US06/103,474 US4315851A (en) | 1978-12-29 | 1979-12-14 | Pharmaceutical composition having antitumor activity |
SE7910483A SE7910483L (en) | 1978-12-29 | 1979-12-19 | PHARMACEUTICAL COMPOSITION WITH TUMOR INHIBITION EFFECT |
PH23447A PH16902A (en) | 1978-12-29 | 1979-12-20 | Pharmaceutical composition having anti-tumor activity |
CH11501/79A CH655010A5 (en) | 1978-12-29 | 1979-12-28 | PHARMACEUTICAL ACTIVE SUBSTANCE WITH ANTITUM ORACTIVITY. |
FR797932054A FR2445149B1 (en) | 1978-12-29 | 1979-12-28 | PHARMACEUTICAL COMPOSITION HAVING ANTI-TUMOR ACTIVITY |
GB7944494A GB2038836B (en) | 1978-12-29 | 1979-12-28 | Antitumour substance |
DE2952690A DE2952690C2 (en) | 1978-12-29 | 1979-12-29 | Antitumor substance, process for their preparation and pharmaceutical agent containing them |
IT28464/79A IT1127324B (en) | 1978-12-29 | 1979-12-31 | Antitumour compsn. contg. high purity antibody |
US06/321,486 US4401592A (en) | 1978-12-29 | 1981-11-16 | Pharmaceutical composition having antitumor activity |
SE8406511A SE8406511L (en) | 1978-12-29 | 1984-12-20 | PHARMACEUTICAL COMPOSITION WITH TUMOR INHIBITION EFFECT |
SE8406510A SE8406510D0 (en) | 1978-12-29 | 1984-12-20 | PHARMACEUTICAL COMPOSITION WITH TUMOR INHIBITION EFFECT |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14215379A JPS5665829A (en) | 1979-11-02 | 1979-11-02 | Antitumor agent |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5665829A true JPS5665829A (en) | 1981-06-03 |
JPS6256137B2 JPS6256137B2 (en) | 1987-11-24 |
Family
ID=15308586
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14215379A Granted JPS5665829A (en) | 1978-12-29 | 1979-11-02 | Antitumor agent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5665829A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62142124A (en) * | 1983-04-08 | 1987-06-25 | Kureha Chem Ind Co Ltd | Antitumor agent bonded with with human immunoglobulin |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01257331A (en) * | 1987-12-10 | 1989-10-13 | Fuji Electric Co Ltd | Microwave matching apparatus and microwave matching |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4962194A (en) * | 1972-05-10 | 1974-06-17 | ||
JPS5161640A (en) * | 1974-09-20 | 1976-05-28 | Searle & Co | Koshuyozaino seizoho |
JPS51144723A (en) * | 1975-05-27 | 1976-12-13 | Yeda Res & Dev | Antiitumor agent |
-
1979
- 1979-11-02 JP JP14215379A patent/JPS5665829A/en active Granted
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4962194A (en) * | 1972-05-10 | 1974-06-17 | ||
JPS5161640A (en) * | 1974-09-20 | 1976-05-28 | Searle & Co | Koshuyozaino seizoho |
JPS51144723A (en) * | 1975-05-27 | 1976-12-13 | Yeda Res & Dev | Antiitumor agent |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62142124A (en) * | 1983-04-08 | 1987-06-25 | Kureha Chem Ind Co Ltd | Antitumor agent bonded with with human immunoglobulin |
JPH0611714B2 (en) * | 1983-04-08 | 1994-02-16 | 呉羽化学工業株式会社 | Human immunoglobulin-binding antitumor agent |
Also Published As
Publication number | Publication date |
---|---|
JPS6256137B2 (en) | 1987-11-24 |
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