JPS5661314A - Preventive against side-effect for dialytic patient - Google Patents
Preventive against side-effect for dialytic patientInfo
- Publication number
- JPS5661314A JPS5661314A JP13803079A JP13803079A JPS5661314A JP S5661314 A JPS5661314 A JP S5661314A JP 13803079 A JP13803079 A JP 13803079A JP 13803079 A JP13803079 A JP 13803079A JP S5661314 A JPS5661314 A JP S5661314A
- Authority
- JP
- Japan
- Prior art keywords
- preventive
- carnitine
- patient
- dialytic
- actions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003449 preventive effect Effects 0.000 title abstract 4
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 210000004204 blood vessel Anatomy 0.000 abstract 2
- 229960004203 carnitine Drugs 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 230000009931 harmful effect Effects 0.000 abstract 2
- 206010019233 Headaches Diseases 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 208000002173 dizziness Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000037149 energy metabolism Effects 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 208000018997 giddiness Diseases 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 210000003470 mitochondria Anatomy 0.000 abstract 1
- 230000002107 myocardial effect Effects 0.000 abstract 1
- 210000004165 myocardium Anatomy 0.000 abstract 1
- QAQREVBBADEHPA-IEXPHMLFSA-N propionyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 QAQREVBBADEHPA-IEXPHMLFSA-N 0.000 abstract 1
- 230000003313 weakening effect Effects 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PURPOSE: A preventive for a dialytic patient against side effects, e.g., disorder of blood vessel of heart, weaking of the whole body, etc., comprising carnitine or its salt.
CONSTITUTION: A preventive comprising a dl-, d-, or l-derivative of carnitine shown by the formula or their pharmaceutically acceptable salts as an active ingredient. When a patient of renopathy, etc. is subjected to dialysis continuously, harmful actions such as disorder of blood vessel of heart, e.g, arrhythmia, myocardial infraction, etc., weakening of the whole body, giddiness, headache, etc. occur. But the administration of carmitine is capable of preventing and remedying these harmful actions. The preventive is prescribed orally or parenterally. The reason is uncertain, but the fact that carnitine or its salt reduces a concentration of fatty acid in the blood and has actions to promote the absorption of long-chain Acyl- CoA to mitochondria membtane and to improve the energy metabolism of cardiac muscle is considered to be related to the reason.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13803079A JPS5661314A (en) | 1979-10-24 | 1979-10-24 | Preventive against side-effect for dialytic patient |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13803079A JPS5661314A (en) | 1979-10-24 | 1979-10-24 | Preventive against side-effect for dialytic patient |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2212937A Division JPH06102624B2 (en) | 1990-08-10 | 1990-08-10 | Anti-arrhythmic drugs of non-heart origin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5661314A true JPS5661314A (en) | 1981-05-26 |
| JPH0440328B2 JPH0440328B2 (en) | 1992-07-02 |
Family
ID=15212397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13803079A Granted JPS5661314A (en) | 1979-10-24 | 1979-10-24 | Preventive against side-effect for dialytic patient |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5661314A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60156613A (en) * | 1984-01-24 | 1985-08-16 | Japan Hosupitaru Supply:Kk | Preventive agent for dialysis shock |
| GB2230953A (en) * | 1989-05-05 | 1990-11-07 | Sigma Tau Ind Farmaceuti | Compositions containing D-carnitine or an acyl derivative for the treatment of protozoal disease |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54151130A (en) * | 1978-05-15 | 1979-11-28 | Cavazza Claudio | Treating agent for kidney disease |
-
1979
- 1979-10-24 JP JP13803079A patent/JPS5661314A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54151130A (en) * | 1978-05-15 | 1979-11-28 | Cavazza Claudio | Treating agent for kidney disease |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60156613A (en) * | 1984-01-24 | 1985-08-16 | Japan Hosupitaru Supply:Kk | Preventive agent for dialysis shock |
| GB2230953A (en) * | 1989-05-05 | 1990-11-07 | Sigma Tau Ind Farmaceuti | Compositions containing D-carnitine or an acyl derivative for the treatment of protozoal disease |
| GB2230953B (en) * | 1989-05-05 | 1993-03-24 | Sigma Tau Ind Farmaceuti | Compositions containing d-carnitine or an acyl derivative for the treatment of protozoal disease |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0440328B2 (en) | 1992-07-02 |
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