JPS5657762A - Nitrosourea derivative* its manufacture* drug composition containing it and urea derivative for said manufacture - Google Patents
Nitrosourea derivative* its manufacture* drug composition containing it and urea derivative for said manufactureInfo
- Publication number
- JPS5657762A JPS5657762A JP13782580A JP13782580A JPS5657762A JP S5657762 A JPS5657762 A JP S5657762A JP 13782580 A JP13782580 A JP 13782580A JP 13782580 A JP13782580 A JP 13782580A JP S5657762 A JPS5657762 A JP S5657762A
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- manufacture
- atoms inclusive
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OSTGTTZJOCZWJG-UHFFFAOYSA-N nitrosourea Chemical class NC(=O)N=NO OSTGTTZJOCZWJG-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 2
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 150000003672 ureas Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000000118 anti-neoplastic effect Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/66—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to halogen atoms or to nitro or nitroso groups
- C07C275/68—N-nitroso ureas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7934306 | 1979-10-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5657762A true JPS5657762A (en) | 1981-05-20 |
Family
ID=10508260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13782580A Pending JPS5657762A (en) | 1979-10-03 | 1980-10-03 | Nitrosourea derivative* its manufacture* drug composition containing it and urea derivative for said manufacture |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4384140A (ja) |
| EP (1) | EP0026989B1 (ja) |
| JP (1) | JPS5657762A (ja) |
| AT (1) | ATE7137T1 (ja) |
| AU (1) | AU539986B2 (ja) |
| DE (1) | DE3067553D1 (ja) |
| DK (1) | DK417380A (ja) |
| FI (1) | FI802903A (ja) |
| IE (1) | IE50228B1 (ja) |
| NO (1) | NO150316C (ja) |
| NZ (1) | NZ194777A (ja) |
| ZA (1) | ZA805421B (ja) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010511624A (ja) * | 2006-12-01 | 2010-04-15 | ブリストル−マイヤーズ スクイブ カンパニー | アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8205324L (sv) * | 1982-09-17 | 1984-03-18 | Leo Ab | Nya n-nitrosoforeningar, kompositioner innehallande sadana foreningar, framstellningsforfaranden och behandlingsmetoder |
| GB8500615D0 (en) * | 1985-01-10 | 1985-02-13 | Lundbeck & Co As H | Organic compounds |
| CA2163325A1 (en) * | 1994-11-21 | 1996-05-22 | Kaneyoshi Kato | Amine compounds, their production and use |
| WO1998043628A1 (fr) * | 1997-04-02 | 1998-10-08 | Viktor Veniaminovich Tets | Remede antitumoral (chlonidane) |
| FR2772616B1 (fr) * | 1997-12-24 | 2000-02-25 | Caster | Composition depigmentante |
-
1980
- 1980-08-25 IE IE1789/80A patent/IE50228B1/en unknown
- 1980-08-26 NZ NZ194777A patent/NZ194777A/xx unknown
- 1980-09-02 ZA ZA00805421A patent/ZA805421B/xx unknown
- 1980-09-10 DE DE8080303187T patent/DE3067553D1/de not_active Expired
- 1980-09-10 EP EP80303187A patent/EP0026989B1/en not_active Expired
- 1980-09-10 AT AT80303187T patent/ATE7137T1/de not_active IP Right Cessation
- 1980-09-16 FI FI802903A patent/FI802903A/fi not_active Application Discontinuation
- 1980-10-02 AU AU62911/80A patent/AU539986B2/en not_active Expired - Fee Related
- 1980-10-02 NO NO802925A patent/NO150316C/no unknown
- 1980-10-03 DK DK417380A patent/DK417380A/da not_active Application Discontinuation
- 1980-10-03 JP JP13782580A patent/JPS5657762A/ja active Pending
-
1982
- 1982-02-16 US US06/348,724 patent/US4384140A/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010511624A (ja) * | 2006-12-01 | 2010-04-15 | ブリストル−マイヤーズ スクイブ カンパニー | アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| US4384140A (en) | 1983-05-17 |
| IE50228B1 (en) | 1986-03-05 |
| NZ194777A (en) | 1983-06-14 |
| EP0026989A2 (en) | 1981-04-15 |
| NO150316C (no) | 1984-10-03 |
| DE3067553D1 (en) | 1984-05-24 |
| AU539986B2 (en) | 1984-10-25 |
| DK417380A (da) | 1981-04-04 |
| EP0026989B1 (en) | 1984-04-18 |
| FI802903A (fi) | 1981-04-04 |
| AU6291180A (en) | 1981-04-09 |
| NO802925L (no) | 1981-04-06 |
| IE801789L (en) | 1981-04-03 |
| EP0026989A3 (en) | 1981-06-24 |
| NO150316B (no) | 1984-06-18 |
| ZA805421B (en) | 1981-09-30 |
| ATE7137T1 (de) | 1984-05-15 |
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