JPS5646817A - Saponin antitumor agent - Google Patents

Saponin antitumor agent

Info

Publication number
JPS5646817A
JPS5646817A JP12459379A JP12459379A JPS5646817A JP S5646817 A JPS5646817 A JP S5646817A JP 12459379 A JP12459379 A JP 12459379A JP 12459379 A JP12459379 A JP 12459379A JP S5646817 A JPS5646817 A JP S5646817A
Authority
JP
Japan
Prior art keywords
fraction
ginsenoside
meyer
silica gel
column chromatography
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP12459379A
Other languages
Japanese (ja)
Other versions
JPS6337085B2 (en
Inventor
Ryuta Ito
Jiyoubai Gen
Kanjiyun Chiyou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ITO RIYUUTA
Original Assignee
ITO RIYUUTA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ITO RIYUUTA filed Critical ITO RIYUUTA
Priority to JP12459379A priority Critical patent/JPS5646817A/en
Publication of JPS5646817A publication Critical patent/JPS5646817A/en
Publication of JPS6337085B2 publication Critical patent/JPS6337085B2/ja
Granted legal-status Critical Current

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)

Abstract

PURPOSE: An antitumor agent effective against various kinds of tumors, having controlling effect on the side effects of other carcinostatic, comprising purified ginsenoside obtained by fractionating total saponin of Panax Ginseng C. A. Meyer by means of silica gel column chromatography.
CONSTITUTION: Total saponin obtained from the whole herb of Panax Ginseng C. A. Meyer is subjected to silica gel column chromatography and developed by various kinds of solvents to fractionate many kinds of ginsenoside. A fraction (GR-A fraction) comprising Rgl of purified ginsenoside, or Rgl as a main ingredient and one or both of Rg2 and Rf, and a fraction (GR-D fraction) comprising Rb1, or Rb1 as a main ingredient and one or all of Rb2, Ra and Ro, have strong antitumor activity. The use of these fractions together with mitomycin, etc. exhibits synergistic effect and action to improve immunlolgical competence of a host, and has preventing and reducing effect on the side effects of other carcinostatics.
COPYRIGHT: (C)1981,JPO&Japio
JP12459379A 1979-09-27 1979-09-27 Saponin antitumor agent Granted JPS5646817A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12459379A JPS5646817A (en) 1979-09-27 1979-09-27 Saponin antitumor agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12459379A JPS5646817A (en) 1979-09-27 1979-09-27 Saponin antitumor agent

Publications (2)

Publication Number Publication Date
JPS5646817A true JPS5646817A (en) 1981-04-28
JPS6337085B2 JPS6337085B2 (en) 1988-07-22

Family

ID=14889285

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12459379A Granted JPS5646817A (en) 1979-09-27 1979-09-27 Saponin antitumor agent

Country Status (1)

Country Link
JP (1) JPS5646817A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6222721A (en) * 1985-07-24 1987-01-30 Noebia:Kk Agent for alleviating mutagenesis
US6071521A (en) * 1989-09-04 2000-06-06 Kim; Song Bae Pharmaceutical composition having an antitumor activity and a process for preparation thereof
DE10158281A1 (en) * 2001-11-19 2003-05-28 Mediwirk Gmbh Pharmaceutical preparation comprises ginsenoside enclosed in micro-shell, e.g. liposome, providing targeted and controlled delivery, useful e.g. in treatment of liver tumors, diabetes mellitus or hypertension
CN104383290A (en) * 2014-12-13 2015-03-04 李菲 Body resistance supporting medicine for treating early-stage esophageal cancer and preparation method of body resistance supporting medicine

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0528689Y2 (en) * 1988-08-26 1993-07-23
JPH0344876U (en) * 1989-09-12 1991-04-25

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6222721A (en) * 1985-07-24 1987-01-30 Noebia:Kk Agent for alleviating mutagenesis
US6071521A (en) * 1989-09-04 2000-06-06 Kim; Song Bae Pharmaceutical composition having an antitumor activity and a process for preparation thereof
DE10158281A1 (en) * 2001-11-19 2003-05-28 Mediwirk Gmbh Pharmaceutical preparation comprises ginsenoside enclosed in micro-shell, e.g. liposome, providing targeted and controlled delivery, useful e.g. in treatment of liver tumors, diabetes mellitus or hypertension
CN104383290A (en) * 2014-12-13 2015-03-04 李菲 Body resistance supporting medicine for treating early-stage esophageal cancer and preparation method of body resistance supporting medicine

Also Published As

Publication number Publication date
JPS6337085B2 (en) 1988-07-22

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