JPS5646817A - Saponin antitumor agent - Google Patents
Saponin antitumor agentInfo
- Publication number
- JPS5646817A JPS5646817A JP12459379A JP12459379A JPS5646817A JP S5646817 A JPS5646817 A JP S5646817A JP 12459379 A JP12459379 A JP 12459379A JP 12459379 A JP12459379 A JP 12459379A JP S5646817 A JPS5646817 A JP S5646817A
- Authority
- JP
- Japan
- Prior art keywords
- fraction
- ginsenoside
- meyer
- silica gel
- column chromatography
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
Abstract
PURPOSE: An antitumor agent effective against various kinds of tumors, having controlling effect on the side effects of other carcinostatic, comprising purified ginsenoside obtained by fractionating total saponin of Panax Ginseng C. A. Meyer by means of silica gel column chromatography.
CONSTITUTION: Total saponin obtained from the whole herb of Panax Ginseng C. A. Meyer is subjected to silica gel column chromatography and developed by various kinds of solvents to fractionate many kinds of ginsenoside. A fraction (GR-A fraction) comprising Rgl of purified ginsenoside, or Rgl as a main ingredient and one or both of Rg2 and Rf, and a fraction (GR-D fraction) comprising Rb1, or Rb1 as a main ingredient and one or all of Rb2, Ra and Ro, have strong antitumor activity. The use of these fractions together with mitomycin, etc. exhibits synergistic effect and action to improve immunlolgical competence of a host, and has preventing and reducing effect on the side effects of other carcinostatics.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12459379A JPS5646817A (en) | 1979-09-27 | 1979-09-27 | Saponin antitumor agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12459379A JPS5646817A (en) | 1979-09-27 | 1979-09-27 | Saponin antitumor agent |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5646817A true JPS5646817A (en) | 1981-04-28 |
JPS6337085B2 JPS6337085B2 (en) | 1988-07-22 |
Family
ID=14889285
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12459379A Granted JPS5646817A (en) | 1979-09-27 | 1979-09-27 | Saponin antitumor agent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5646817A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6222721A (en) * | 1985-07-24 | 1987-01-30 | Noebia:Kk | Agent for alleviating mutagenesis |
US6071521A (en) * | 1989-09-04 | 2000-06-06 | Kim; Song Bae | Pharmaceutical composition having an antitumor activity and a process for preparation thereof |
DE10158281A1 (en) * | 2001-11-19 | 2003-05-28 | Mediwirk Gmbh | Pharmaceutical preparation comprises ginsenoside enclosed in micro-shell, e.g. liposome, providing targeted and controlled delivery, useful e.g. in treatment of liver tumors, diabetes mellitus or hypertension |
CN104383290A (en) * | 2014-12-13 | 2015-03-04 | 李菲 | Body resistance supporting medicine for treating early-stage esophageal cancer and preparation method of body resistance supporting medicine |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0528689Y2 (en) * | 1988-08-26 | 1993-07-23 | ||
JPH0344876U (en) * | 1989-09-12 | 1991-04-25 |
-
1979
- 1979-09-27 JP JP12459379A patent/JPS5646817A/en active Granted
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6222721A (en) * | 1985-07-24 | 1987-01-30 | Noebia:Kk | Agent for alleviating mutagenesis |
US6071521A (en) * | 1989-09-04 | 2000-06-06 | Kim; Song Bae | Pharmaceutical composition having an antitumor activity and a process for preparation thereof |
DE10158281A1 (en) * | 2001-11-19 | 2003-05-28 | Mediwirk Gmbh | Pharmaceutical preparation comprises ginsenoside enclosed in micro-shell, e.g. liposome, providing targeted and controlled delivery, useful e.g. in treatment of liver tumors, diabetes mellitus or hypertension |
CN104383290A (en) * | 2014-12-13 | 2015-03-04 | 李菲 | Body resistance supporting medicine for treating early-stage esophageal cancer and preparation method of body resistance supporting medicine |
Also Published As
Publication number | Publication date |
---|---|
JPS6337085B2 (en) | 1988-07-22 |
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