JPS5634619A - Production of prostaglandin vaginal suppository - Google Patents
Production of prostaglandin vaginal suppositoryInfo
- Publication number
- JPS5634619A JPS5634619A JP11046979A JP11046979A JPS5634619A JP S5634619 A JPS5634619 A JP S5634619A JP 11046979 A JP11046979 A JP 11046979A JP 11046979 A JP11046979 A JP 11046979A JP S5634619 A JPS5634619 A JP S5634619A
- Authority
- JP
- Japan
- Prior art keywords
- dissolved
- solution
- organic solvent
- suppository
- prostaglandin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: A carrier such as cellulose is dissolved in a organic solvent and prostaglandin and an organic acid are added to the solution, then they are dried to give the titled vaginal supporsitory that gradually and continuously release the effective component and is used as a remedy with high biological efficiency.
CONSTITUTION: A carrier such as hydrocycellulose is dissolved in an organic solvent such as an alcohol. When the solution becomes clear, prostglandin and an organic acid such as citric acid which have previously been dissolved in an organic solvent are combined with the above solution and stirring is continued until the mixture becomes homogeneous. The resultant solution is formed into films with a device equipped with temperature and wind regulators through the casting process.
EFFECT: The suppository shows adquate effectiveness with little dose. The film-forming process is effected at low temperatures and so, even unstable substances do not decompose substantially during the process. The high stability is kept for a long time. Since the suppository has a small size and undertake little softening and deformation, the insertion into vagina is easy. The pharmacological effectiveness continues for a long time with less fluctuation.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11046979A JPS5634619A (en) | 1979-08-31 | 1979-08-31 | Production of prostaglandin vaginal suppository |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11046979A JPS5634619A (en) | 1979-08-31 | 1979-08-31 | Production of prostaglandin vaginal suppository |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5634619A true JPS5634619A (en) | 1981-04-06 |
JPH0132205B2 JPH0132205B2 (en) | 1989-06-29 |
Family
ID=14536489
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11046979A Granted JPS5634619A (en) | 1979-08-31 | 1979-08-31 | Production of prostaglandin vaginal suppository |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5634619A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5832816A (en) * | 1981-08-20 | 1983-02-25 | Shin Etsu Chem Co Ltd | Contraceptive film pharmaceutical |
EP0119156A2 (en) * | 1983-03-02 | 1984-09-19 | Schering Aktiengesellschaft | Prostaglandin-containing pharmaceutical composition and its preparation |
US4542020A (en) * | 1984-08-17 | 1985-09-17 | E. R. Squibb & Sons, Inc. | Long-lasting adhesive antifungal suppositories |
US4572832A (en) * | 1982-10-07 | 1986-02-25 | Grelan Pharmaceutical Co., Ltd. | Soft buccal |
JPS6176623A (en) * | 1984-09-25 | 1986-04-19 | Babcock Hitachi Kk | Improving method impact-resisting property of heat affected zone after buildup welding |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49133519A (en) * | 1972-12-18 | 1974-12-21 | ||
JPS5088054A (en) * | 1973-12-07 | 1975-07-15 | ||
JPS539110A (en) * | 1976-07-14 | 1978-01-27 | Fujitsu Ltd | Magnetic head of vertical magnetization recording system |
JPS53148518A (en) * | 1977-06-01 | 1978-12-25 | Kaken Pharmaceut Co Ltd | Stabilized prostaglandin e composition and its preparation |
-
1979
- 1979-08-31 JP JP11046979A patent/JPS5634619A/en active Granted
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS49133519A (en) * | 1972-12-18 | 1974-12-21 | ||
JPS5088054A (en) * | 1973-12-07 | 1975-07-15 | ||
JPS539110A (en) * | 1976-07-14 | 1978-01-27 | Fujitsu Ltd | Magnetic head of vertical magnetization recording system |
JPS53148518A (en) * | 1977-06-01 | 1978-12-25 | Kaken Pharmaceut Co Ltd | Stabilized prostaglandin e composition and its preparation |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5832816A (en) * | 1981-08-20 | 1983-02-25 | Shin Etsu Chem Co Ltd | Contraceptive film pharmaceutical |
JPS6222965B2 (en) * | 1981-08-20 | 1987-05-20 | Shinetsu Chem Ind Co | |
US4572832A (en) * | 1982-10-07 | 1986-02-25 | Grelan Pharmaceutical Co., Ltd. | Soft buccal |
EP0119156A2 (en) * | 1983-03-02 | 1984-09-19 | Schering Aktiengesellschaft | Prostaglandin-containing pharmaceutical composition and its preparation |
US4542020A (en) * | 1984-08-17 | 1985-09-17 | E. R. Squibb & Sons, Inc. | Long-lasting adhesive antifungal suppositories |
JPS6176623A (en) * | 1984-09-25 | 1986-04-19 | Babcock Hitachi Kk | Improving method impact-resisting property of heat affected zone after buildup welding |
Also Published As
Publication number | Publication date |
---|---|
JPH0132205B2 (en) | 1989-06-29 |
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