JPS5630916A - Organogermanium compound, its preparation and external dermatic drug containing the same - Google Patents
Organogermanium compound, its preparation and external dermatic drug containing the sameInfo
- Publication number
- JPS5630916A JPS5630916A JP10747779A JP10747779A JPS5630916A JP S5630916 A JPS5630916 A JP S5630916A JP 10747779 A JP10747779 A JP 10747779A JP 10747779 A JP10747779 A JP 10747779A JP S5630916 A JPS5630916 A JP S5630916A
- Authority
- JP
- Japan
- Prior art keywords
- effects
- germanium
- external
- bis
- reacted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 Organogermanium compound Chemical class 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 230000000694 effects Effects 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052732 germanium Inorganic materials 0.000 abstract 2
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 abstract 2
- STVJEHWLHRXNRT-UHFFFAOYSA-N C(CCCCCCC)C(C[Ge])CCCCCCCCCC Chemical compound C(CCCCCCC)C(C[Ge])CCCCCCCCCC STVJEHWLHRXNRT-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 208000017657 Menopausal disease Diseases 0.000 abstract 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 208000002925 dental caries Diseases 0.000 abstract 1
- 239000000551 dentifrice Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229940093626 germanium sesquioxide Drugs 0.000 abstract 1
- 235000001497 healthy food Nutrition 0.000 abstract 1
- 239000004009 herbicide Substances 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 230000005976 liver dysfunction Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229940126701 oral medication Drugs 0.000 abstract 1
- 230000019612 pigmentation Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 230000037303 wrinkles Effects 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NEW MATERIAL:The titled compound of the formula [X is OR1 (R1 is H etc.); R2 and R3 are H, alkyls, etc. except when all the R1, R2 and R3 are H and R1 is 1W12C saturated straight chain alcohol].
EXAMPLE: Bis-β-propionic acid 2-octyldodecylgermanium sesquioxide [or bis(2- octyldodecyl β-propionato)germanium sesquioxide].
USE: An external dermatic drug having improving effects on the features of various intractable diseases, e.g. liver dysfunction or menopausal disorder, effects on dermatoses, e.g. psoriasis vulgaris or pigmentation, or beautifying effects on the skin, e.g. preventing or improving fine wrinkles or fair effects. Various healthy foods, herbicides, dentifrice for preventing dental caries or oral drugs.
PROCESS: A germanium tetrahalide is reacted with a trihalogenosilane to give an organic salt of a germanium trihalide, which is then reacted with an α,β-unsaturated ester, and hydrolyzed to afford the compound of the formula in high yield.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10747779A JPS5630916A (en) | 1979-08-23 | 1979-08-23 | Organogermanium compound, its preparation and external dermatic drug containing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10747779A JPS5630916A (en) | 1979-08-23 | 1979-08-23 | Organogermanium compound, its preparation and external dermatic drug containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5630916A true JPS5630916A (en) | 1981-03-28 |
JPS6328070B2 JPS6328070B2 (en) | 1988-06-07 |
Family
ID=14460194
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10747779A Granted JPS5630916A (en) | 1979-08-23 | 1979-08-23 | Organogermanium compound, its preparation and external dermatic drug containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5630916A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57126408A (en) * | 1981-01-28 | 1982-08-06 | Kiyo Kondo | Cosmetic containing germanium |
JPS5987925U (en) * | 1982-12-06 | 1984-06-14 | 笠原工業株式会社 | Granular "pou" |
JPS60199816A (en) * | 1984-03-23 | 1985-10-09 | Gerumaniumu Kogyo Kk | Spraylike organogermanium agent containing organogermanium sealed in sealed container |
KR20030014941A (en) * | 2001-08-13 | 2003-02-20 | 추대일 | functional toothpaste component |
JP2004231600A (en) * | 2003-01-31 | 2004-08-19 | Takemitsu Ishigaki | Skin care preparation for external use |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54160319A (en) * | 1978-06-08 | 1979-12-19 | Asai Germanium Res Inst | Manufacture of organic germanium compound |
-
1979
- 1979-08-23 JP JP10747779A patent/JPS5630916A/en active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54160319A (en) * | 1978-06-08 | 1979-12-19 | Asai Germanium Res Inst | Manufacture of organic germanium compound |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57126408A (en) * | 1981-01-28 | 1982-08-06 | Kiyo Kondo | Cosmetic containing germanium |
JPS5987925U (en) * | 1982-12-06 | 1984-06-14 | 笠原工業株式会社 | Granular "pou" |
JPS60199816A (en) * | 1984-03-23 | 1985-10-09 | Gerumaniumu Kogyo Kk | Spraylike organogermanium agent containing organogermanium sealed in sealed container |
KR20030014941A (en) * | 2001-08-13 | 2003-02-20 | 추대일 | functional toothpaste component |
JP2004231600A (en) * | 2003-01-31 | 2004-08-19 | Takemitsu Ishigaki | Skin care preparation for external use |
Also Published As
Publication number | Publication date |
---|---|
JPS6328070B2 (en) | 1988-06-07 |
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