JPS5622800A - Novel 177**hydroxymethyl**formamido*methylene*steroid derivative* its manufacture and its application to introduction of hydroxyacetyl side chain - Google Patents

Novel 177**hydroxymethyl**formamido*methylene*steroid derivative* its manufacture and its application to introduction of hydroxyacetyl side chain

Info

Publication number
JPS5622800A
JPS5622800A JP10378580A JP10378580A JPS5622800A JP S5622800 A JPS5622800 A JP S5622800A JP 10378580 A JP10378580 A JP 10378580A JP 10378580 A JP10378580 A JP 10378580A JP S5622800 A JPS5622800 A JP S5622800A
Authority
JP
Japan
Prior art keywords
formamido
hydroxymethyl
methylene
introduction
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10378580A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6338040B2 (enExample
Inventor
Nedoretsuku Riyushian
Toreri Besuperuto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of JPS5622800A publication Critical patent/JPS5622800A/ja
Publication of JPS6338040B2 publication Critical patent/JPS6338040B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
JP10378580A 1979-07-31 1980-07-30 Novel 177**hydroxymethyl**formamido*methylene*steroid derivative* its manufacture and its application to introduction of hydroxyacetyl side chain Granted JPS5622800A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7919653A FR2462445A1 (fr) 1979-07-31 1979-07-31 Nouveaux derives 17-/(hydroxymethyl) (formamido) methylene/steroides, leur procede de preparation et leur application a l'introduction de la chaine laterale hydroxyacetyle

Publications (2)

Publication Number Publication Date
JPS5622800A true JPS5622800A (en) 1981-03-03
JPS6338040B2 JPS6338040B2 (enExample) 1988-07-28

Family

ID=9228478

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10378580A Granted JPS5622800A (en) 1979-07-31 1980-07-30 Novel 177**hydroxymethyl**formamido*methylene*steroid derivative* its manufacture and its application to introduction of hydroxyacetyl side chain

Country Status (5)

Country Link
US (1) US4464302A (enExample)
EP (2) EP0056000B1 (enExample)
JP (1) JPS5622800A (enExample)
FR (1) FR2462445A1 (enExample)
HU (1) HU182158B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2498607A1 (fr) * 1981-01-29 1982-07-30 Roussel Uclaf Nouveau procede de preparation de 17a-hydroxy 17b-hydroxyacetyle steroides, produits intermediaires correspondants et produits finals obtenus
FR2521567A1 (fr) * 1982-02-18 1983-08-19 Roussel Uclaf Nouveaux derives steroides 17(20)nitro, leur procede de preparation et leur application a la preparation de corticosteroides
EP0123734A1 (en) * 1983-04-29 1984-11-07 Gist-Brocades N.V. 17-(Isocyano-sulfonylmethylene)-steroids, 17-(formamido-sulfonylmethylene)-steroids and their preparation
EP0123736A1 (en) * 1983-04-29 1984-11-07 Gist-Brocades N.V. New process for the preparation of 21-hydroxy-20-keto-delta 16-steroids and new intermediate compounds formed in this process
FR2569408B1 (fr) * 1984-08-24 1986-10-03 Roussel Uclaf Nouveaux steroides substitues en position 10 par un radical comportant une double ou triple liaison, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant
HU196433B (en) * 1984-09-12 1988-11-28 Gyogyszerkutato Intezet Process for producing new 20-amino-steroides
FR2594829B1 (fr) * 1986-02-24 1988-06-03 Roussel Uclaf Nouveaux steroides 9 (11) satures substitues en position 10 par un radical comportant une triple liaison, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant
ES2033516T3 (es) * 1988-04-08 1993-03-16 Roussel-Uclaf Procedimiento para preparar 9 alfa-hidroxi-17 metileno-esteroides.
US4910191A (en) * 1988-06-28 1990-03-20 Merrell Dow Pharmaceuticals Inc. 19-substituted progesterone derivatives useful as 19-hydroxylase inhibitors
US4920114A (en) * 1988-06-28 1990-04-24 Merrell Dow Pharmaceuticals Inc. 19-fluoro- or cyano-21-hydroxyprogesterone derivatives useful as 19-hydroxylase inhibitors
FR2683530B1 (fr) * 1991-11-08 1994-01-21 Roussel Uclaf Nouveau procede de preparation de derives 20-oxo 17 alpha, 21-dihydroxyles du pregnane et nouveaux intermediaires.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1643004A1 (de) * 1967-02-07 1971-04-08 Schering Ag Bisnorcholenderivate und Verfahren zu ihrer Herstellung
US3816480A (en) * 1973-07-30 1974-06-11 Searle & Co -oxygenated 21-dialkylamino-20-methyl-5alpha-pregn-17(20)-dien-3-ones and congeners

Also Published As

Publication number Publication date
EP0023856A2 (fr) 1981-02-11
EP0056000A2 (fr) 1982-07-14
EP0023856B1 (fr) 1983-05-25
EP0023856A3 (en) 1981-04-08
JPS6338040B2 (enExample) 1988-07-28
EP0056000B1 (fr) 1984-09-26
FR2462445A1 (fr) 1981-02-13
EP0056000A3 (en) 1982-07-28
FR2462445B1 (enExample) 1982-02-12
HU182158B (en) 1983-12-28
US4464302A (en) 1984-08-07

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