JPS5622796A - Novel derivative of demycarosyl-macrolide antibiotic - Google Patents
Novel derivative of demycarosyl-macrolide antibioticInfo
- Publication number
- JPS5622796A JPS5622796A JP9867879A JP9867879A JPS5622796A JP S5622796 A JPS5622796 A JP S5622796A JP 9867879 A JP9867879 A JP 9867879A JP 9867879 A JP9867879 A JP 9867879A JP S5622796 A JPS5622796 A JP S5622796A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- demycarosyl
- macrolide antibiotic
- derivative
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
NEW MATERIAL:(4'-Substituted)-demycarosyl-macrolide antibiotic derivative of formula I [R1 is -CH2CHO, formula II (R5 is alkyl); A is formula III(R5 is alkyl); B is formula IV].
EXAMPLE: 9,2'-Di-O-acetyl-4'-O-methanesulfonyl-demycarosyl-SF-837 A1 substance.
USE: Antibiotic against Gram-positive and -negative cocci and Gram-negative bacilli and synthetic intermediate of macrolide antibiotic derivatives.
PREPARATION: For example, a strong acid is made to act on a macrolide antibiotic or its derivative of formula V (R4 is H, acyl; R9, R10 are acyl) in an organic solvent to form a demycarosyl-macrolide antibiotic substance. The product is made to react with a sulfonyl halide of formula VII (R8 are 1W4 alkyl; Y is halogen) in the presence of a base to produce 4'-sulfonyloxy-demycarosyl-macrolide antibiotic derivative of formula I where group Z is OSO2R8.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9867879A JPS5622796A (en) | 1979-08-03 | 1979-08-03 | Novel derivative of demycarosyl-macrolide antibiotic |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9867879A JPS5622796A (en) | 1979-08-03 | 1979-08-03 | Novel derivative of demycarosyl-macrolide antibiotic |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5622796A true JPS5622796A (en) | 1981-03-03 |
Family
ID=14226163
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9867879A Pending JPS5622796A (en) | 1979-08-03 | 1979-08-03 | Novel derivative of demycarosyl-macrolide antibiotic |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5622796A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5944398A (en) * | 1982-08-02 | 1984-03-12 | フアイザ−・インコ−ポレ−テツド | Antibacterial mycosaminocyltilonolide and related macrolide derivatives |
WO2003011882A1 (en) * | 2001-07-27 | 2003-02-13 | Enanta Pharmaceuticals, Inc. | 4'-substituted leucomycins |
-
1979
- 1979-08-03 JP JP9867879A patent/JPS5622796A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5944398A (en) * | 1982-08-02 | 1984-03-12 | フアイザ−・インコ−ポレ−テツド | Antibacterial mycosaminocyltilonolide and related macrolide derivatives |
WO2003011882A1 (en) * | 2001-07-27 | 2003-02-13 | Enanta Pharmaceuticals, Inc. | 4'-substituted leucomycins |
US6680299B2 (en) | 2001-07-27 | 2004-01-20 | Enanta Pharmaceuticals, Inc. | 4'-substituted leucomycins |
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