JPS5618919A - Thrombolytic agent - Google Patents

Thrombolytic agent

Info

Publication number
JPS5618919A
JPS5618919A JP9472479A JP9472479A JPS5618919A JP S5618919 A JPS5618919 A JP S5618919A JP 9472479 A JP9472479 A JP 9472479A JP 9472479 A JP9472479 A JP 9472479A JP S5618919 A JPS5618919 A JP S5618919A
Authority
JP
Japan
Prior art keywords
compound
effective component
formula
lower alkyl
thrombolytic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9472479A
Other languages
Japanese (ja)
Other versions
JPS6357404B2 (en
Inventor
Katsuaki Nakajima
Susumu Yamamoto
Masami Tsukamoto
Noriyuki Sano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Priority to JP9472479A priority Critical patent/JPS5618919A/en
Publication of JPS5618919A publication Critical patent/JPS5618919A/en
Publication of JPS6357404B2 publication Critical patent/JPS6357404B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PURPOSE: An inexpensive and stable thrombolytic agent that contains a specific bis-trimethoxybenzoate as the effective component.
CONSTITUTION: Said agent contains a compound of the formula (R is H, lower alkyl, lower acyl; R1 is H, lower alkyl, two R1s may incorporate to form lower alkylene; A is straight or branched alkylene; n is 2 or 3) such as 3,3'-[ethylenebis- (methylamino)]di-1-propanol 3,4,5-timethoxybenzoate dihydrochloride as the effective component. The compound of the formula accelerates the decomposition of fibrin (fibrinolysis) by liberation of tissue activator to activate plasminogen and block plasminogen inhibitor. It has lower molecular weight and higher stability than urokinase and streptokinase and shows low acute toxicity and little side-effects.
COPYRIGHT: (C)1981,JPO&Japio
JP9472479A 1979-07-25 1979-07-25 Thrombolytic agent Granted JPS5618919A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9472479A JPS5618919A (en) 1979-07-25 1979-07-25 Thrombolytic agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9472479A JPS5618919A (en) 1979-07-25 1979-07-25 Thrombolytic agent

Publications (2)

Publication Number Publication Date
JPS5618919A true JPS5618919A (en) 1981-02-23
JPS6357404B2 JPS6357404B2 (en) 1988-11-11

Family

ID=14118059

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9472479A Granted JPS5618919A (en) 1979-07-25 1979-07-25 Thrombolytic agent

Country Status (1)

Country Link
JP (1) JPS5618919A (en)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS=1975 *

Also Published As

Publication number Publication date
JPS6357404B2 (en) 1988-11-11

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