JPS56156213A - Preparation of immunologically active fine particle - Google Patents

Preparation of immunologically active fine particle

Info

Publication number
JPS56156213A
JPS56156213A JP5867780A JP5867780A JPS56156213A JP S56156213 A JPS56156213 A JP S56156213A JP 5867780 A JP5867780 A JP 5867780A JP 5867780 A JP5867780 A JP 5867780A JP S56156213 A JPS56156213 A JP S56156213A
Authority
JP
Japan
Prior art keywords
resultant
fine particles
immunologically active
particles
methacrylonitrile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5867780A
Other languages
Japanese (ja)
Other versions
JPS6315552B2 (en
Inventor
Shuntaro Hosaka
Yasuo Murao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to JP5867780A priority Critical patent/JPS56156213A/en
Publication of JPS56156213A publication Critical patent/JPS56156213A/en
Publication of JPS6315552B2 publication Critical patent/JPS6315552B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

PURPOSE: To obtain the titled fine particles for clinical tests having a good measuring sensitivity, by polymerizing acrylonitrile or methacrylonitrile into the form of fine particles, hydrolyzing the fine particles, and reacting an immunological active substance with the resultant specific carrier particles.
CONSTITUTION: Acrylonitrile or methacrylonitrile is polymerized in a medium, e.g. ethyl propionate, which will dissolve the monomer mixture but precipitate and deposit the resultant polymer in the presence of a crosslinkable monomer, e.g. divinylbenzene, having at least two polymerizable carbon-carbon double bonds to precipitate and deposit a fine particulate polymer having an average diameter of 0.03W10μm. The resultant fine particulate polymer is then hydrolyzed and reacted with an immunologically active substance, e.g. syphilitic treponemal antigen or HBs antigen, to give immunologically active fine particles. The resultant carrier consists of polyacrylamide particles having a uniform particle size, and has very little nonspecific adsorption, e.g. protein, and facilitates the measurement.
COPYRIGHT: (C)1981,JPO&Japio
JP5867780A 1980-05-06 1980-05-06 Preparation of immunologically active fine particle Granted JPS56156213A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5867780A JPS56156213A (en) 1980-05-06 1980-05-06 Preparation of immunologically active fine particle

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5867780A JPS56156213A (en) 1980-05-06 1980-05-06 Preparation of immunologically active fine particle

Publications (2)

Publication Number Publication Date
JPS56156213A true JPS56156213A (en) 1981-12-02
JPS6315552B2 JPS6315552B2 (en) 1988-04-05

Family

ID=13091199

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5867780A Granted JPS56156213A (en) 1980-05-06 1980-05-06 Preparation of immunologically active fine particle

Country Status (1)

Country Link
JP (1) JPS56156213A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6126505A (en) * 1984-07-17 1986-02-05 Toray Ind Inc Black particle
JPH02242833A (en) * 1988-11-23 1990-09-27 American Cyanamid Co Porous polyacrylonitrile composition and its preparation and application

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6126505A (en) * 1984-07-17 1986-02-05 Toray Ind Inc Black particle
JPH02242833A (en) * 1988-11-23 1990-09-27 American Cyanamid Co Porous polyacrylonitrile composition and its preparation and application

Also Published As

Publication number Publication date
JPS6315552B2 (en) 1988-04-05

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