JPS56115714A - Injection of water-solubilized vitamin k - Google Patents
Injection of water-solubilized vitamin kInfo
- Publication number
- JPS56115714A JPS56115714A JP1824880A JP1824880A JPS56115714A JP S56115714 A JPS56115714 A JP S56115714A JP 1824880 A JP1824880 A JP 1824880A JP 1824880 A JP1824880 A JP 1824880A JP S56115714 A JPS56115714 A JP S56115714A
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- water
- phospholipid
- fatty acid
- acid ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PURPOSE: To prepare an injection of water-solubilized vitamin K, resistant to clouding with time, by compounding vitamin K which is a hardly water-soluble substance, with a nonionic surface active agent, a phospholipid, and a sorbitan fatty acid ester.
CONSTITUTION: A vitamin K, a nonionic surface active agent (e.g. hardened castor oil polyoxyethylene derivative), a phospholipid (e.g. phosphatidylcholine, phosphatidylserine, etc.), and a sorbitan fatty acid ester are dissolved in water to obtain an injection. The amounts of the components are, 0.1W1pt.wt. of phospholipid and ≥0.2pt.wt. of sorbitan fatty acid ester per 1pt.wt. of vitamin K. The combined use of the phospholipid with the sorbitan fatty acid ester reduces the necessary amount of the surface active agent which is a possible cause of side effects.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1824880A JPS56115714A (en) | 1980-02-15 | 1980-02-15 | Injection of water-solubilized vitamin k |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1824880A JPS56115714A (en) | 1980-02-15 | 1980-02-15 | Injection of water-solubilized vitamin k |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56115714A true JPS56115714A (en) | 1981-09-11 |
Family
ID=11966371
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1824880A Pending JPS56115714A (en) | 1980-02-15 | 1980-02-15 | Injection of water-solubilized vitamin k |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56115714A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005075804A (en) * | 2003-09-03 | 2005-03-24 | Toyo Capsule Kk | Medicinal composition including menatetrenone |
-
1980
- 1980-02-15 JP JP1824880A patent/JPS56115714A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005075804A (en) * | 2003-09-03 | 2005-03-24 | Toyo Capsule Kk | Medicinal composition including menatetrenone |
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