JPS56108734A - Preparation of beta-halogenoisobutyryl halide - Google Patents
Preparation of beta-halogenoisobutyryl halideInfo
- Publication number
- JPS56108734A JPS56108734A JP16237879A JP16237879A JPS56108734A JP S56108734 A JPS56108734 A JP S56108734A JP 16237879 A JP16237879 A JP 16237879A JP 16237879 A JP16237879 A JP 16237879A JP S56108734 A JPS56108734 A JP S56108734A
- Authority
- JP
- Japan
- Prior art keywords
- base
- halogenating reagent
- halogenoisobutyryl
- halide
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the titled substance useful as an intermediate for hypostensive agent, by the simultaneous halogenation of the hydroxyl and the carboxyl groups of β-hydroxyisobutyric acid in one stage with a halogenating reagent, in the presence of an amide compound or a base.
CONSTITUTION: β-Hydroxyisobutyric acid or its salt is reacted with a halogenating reagent, e.g. thionyl chloride, phosphorus trichloride or phosphorus oxychloride, in the presence of an amide compound, e.g. N,N-dimethylformamide, N,N-dimethylacetamide, N-formylmorpholine or N-formylpiperidine, or a base, e.g. an organic base, its hydrochloride, or an inorganic base, in an amount of 0.1W10mol%, at 0W25°C during the addition of the halogenating reagent, and at 30W70°C after the addition, to give the titled substance, especially an optically active substance of D-form.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16237879A JPS56108734A (en) | 1979-12-13 | 1979-12-13 | Preparation of beta-halogenoisobutyryl halide |
GB8038469A GB2065643B (en) | 1979-12-13 | 1980-12-01 | Optically active n-mercaptoalkanoylamino acids |
US06/214,780 US4371699A (en) | 1979-12-13 | 1980-12-09 | Process for preparation of optically active N-mercaptoalkanoylamino acids |
DE19803046271 DE3046271A1 (en) | 1979-12-13 | 1980-12-09 | METHOD FOR PRODUCING OPTICALLY ACTIVE N-MERCAPTOALKANOYLAMINO ACIDS |
FR8026234A FR2471975B1 (en) | 1979-12-13 | 1980-12-10 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-MERCAPTOALCANOYLAMINOACIDS |
IT50342/80A IT1188971B (en) | 1979-12-13 | 1980-12-11 | PROCEDURE FOR PREPARING OPTICALLY ACTIVE N-MERCAPTOALCANOYL-AMINO ACIDS |
IE2603/80A IE50548B1 (en) | 1979-12-13 | 1980-12-12 | Process for preparation of optically active n-mercaptoalkanoylamino acids |
ES497665A ES497665A0 (en) | 1979-12-13 | 1980-12-12 | A PROCEDURE FOR THE PREPARATION OF AN OPTICALLY ACTIVE N-MERCAPTOALCA-NOYLAMINO ACID |
SU803220197A SU1060106A3 (en) | 1979-12-13 | 1980-12-12 | Process for preparing optically active n-mercaptoalkanoylamino acids |
NL8006768A NL192264C (en) | 1979-12-13 | 1980-12-12 | Process for preparing optically active N-mercaptoalkanoylamino acids. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16237879A JPS56108734A (en) | 1979-12-13 | 1979-12-13 | Preparation of beta-halogenoisobutyryl halide |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56108734A true JPS56108734A (en) | 1981-08-28 |
JPS6232181B2 JPS6232181B2 (en) | 1987-07-13 |
Family
ID=15753431
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16237879A Granted JPS56108734A (en) | 1979-12-13 | 1979-12-13 | Preparation of beta-halogenoisobutyryl halide |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56108734A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0434389A2 (en) * | 1989-12-22 | 1991-06-26 | Unichema Chemie B.V. | Use of fatty acid nitrogen derivatives in fatty acid halide preparation |
JPH041155A (en) * | 1989-12-22 | 1992-01-06 | Unichema Chem Bv | Production of fatty acid halogenide |
-
1979
- 1979-12-13 JP JP16237879A patent/JPS56108734A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0434389A2 (en) * | 1989-12-22 | 1991-06-26 | Unichema Chemie B.V. | Use of fatty acid nitrogen derivatives in fatty acid halide preparation |
JPH041155A (en) * | 1989-12-22 | 1992-01-06 | Unichema Chem Bv | Production of fatty acid halogenide |
Also Published As
Publication number | Publication date |
---|---|
JPS6232181B2 (en) | 1987-07-13 |
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