JPS56108734A - Preparation of beta-halogenoisobutyryl halide - Google Patents

Preparation of beta-halogenoisobutyryl halide

Info

Publication number
JPS56108734A
JPS56108734A JP16237879A JP16237879A JPS56108734A JP S56108734 A JPS56108734 A JP S56108734A JP 16237879 A JP16237879 A JP 16237879A JP 16237879 A JP16237879 A JP 16237879A JP S56108734 A JPS56108734 A JP S56108734A
Authority
JP
Japan
Prior art keywords
base
halogenating reagent
halogenoisobutyryl
halide
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16237879A
Other languages
Japanese (ja)
Other versions
JPS6232181B2 (en
Inventor
Takehisa Ohashi
Masami Shimazaki
Kazunori Suga
Hideo Kondo
Kiyoshi Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Priority to JP16237879A priority Critical patent/JPS56108734A/en
Priority to GB8038469A priority patent/GB2065643B/en
Priority to US06/214,780 priority patent/US4371699A/en
Priority to DE19803046271 priority patent/DE3046271A1/en
Priority to FR8026234A priority patent/FR2471975B1/en
Priority to IT50342/80A priority patent/IT1188971B/en
Priority to IE2603/80A priority patent/IE50548B1/en
Priority to ES497665A priority patent/ES497665A0/en
Priority to SU803220197A priority patent/SU1060106A3/en
Priority to NL8006768A priority patent/NL192264C/en
Publication of JPS56108734A publication Critical patent/JPS56108734A/en
Publication of JPS6232181B2 publication Critical patent/JPS6232181B2/ja
Granted legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled substance useful as an intermediate for hypostensive agent, by the simultaneous halogenation of the hydroxyl and the carboxyl groups of β-hydroxyisobutyric acid in one stage with a halogenating reagent, in the presence of an amide compound or a base.
CONSTITUTION: β-Hydroxyisobutyric acid or its salt is reacted with a halogenating reagent, e.g. thionyl chloride, phosphorus trichloride or phosphorus oxychloride, in the presence of an amide compound, e.g. N,N-dimethylformamide, N,N-dimethylacetamide, N-formylmorpholine or N-formylpiperidine, or a base, e.g. an organic base, its hydrochloride, or an inorganic base, in an amount of 0.1W10mol%, at 0W25°C during the addition of the halogenating reagent, and at 30W70°C after the addition, to give the titled substance, especially an optically active substance of D-form.
COPYRIGHT: (C)1981,JPO&Japio
JP16237879A 1979-12-13 1979-12-13 Preparation of beta-halogenoisobutyryl halide Granted JPS56108734A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP16237879A JPS56108734A (en) 1979-12-13 1979-12-13 Preparation of beta-halogenoisobutyryl halide
GB8038469A GB2065643B (en) 1979-12-13 1980-12-01 Optically active n-mercaptoalkanoylamino acids
US06/214,780 US4371699A (en) 1979-12-13 1980-12-09 Process for preparation of optically active N-mercaptoalkanoylamino acids
DE19803046271 DE3046271A1 (en) 1979-12-13 1980-12-09 METHOD FOR PRODUCING OPTICALLY ACTIVE N-MERCAPTOALKANOYLAMINO ACIDS
FR8026234A FR2471975B1 (en) 1979-12-13 1980-12-10 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-MERCAPTOALCANOYLAMINOACIDS
IT50342/80A IT1188971B (en) 1979-12-13 1980-12-11 PROCEDURE FOR PREPARING OPTICALLY ACTIVE N-MERCAPTOALCANOYL-AMINO ACIDS
IE2603/80A IE50548B1 (en) 1979-12-13 1980-12-12 Process for preparation of optically active n-mercaptoalkanoylamino acids
ES497665A ES497665A0 (en) 1979-12-13 1980-12-12 A PROCEDURE FOR THE PREPARATION OF AN OPTICALLY ACTIVE N-MERCAPTOALCA-NOYLAMINO ACID
SU803220197A SU1060106A3 (en) 1979-12-13 1980-12-12 Process for preparing optically active n-mercaptoalkanoylamino acids
NL8006768A NL192264C (en) 1979-12-13 1980-12-12 Process for preparing optically active N-mercaptoalkanoylamino acids.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16237879A JPS56108734A (en) 1979-12-13 1979-12-13 Preparation of beta-halogenoisobutyryl halide

Publications (2)

Publication Number Publication Date
JPS56108734A true JPS56108734A (en) 1981-08-28
JPS6232181B2 JPS6232181B2 (en) 1987-07-13

Family

ID=15753431

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16237879A Granted JPS56108734A (en) 1979-12-13 1979-12-13 Preparation of beta-halogenoisobutyryl halide

Country Status (1)

Country Link
JP (1) JPS56108734A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0434389A2 (en) * 1989-12-22 1991-06-26 Unichema Chemie B.V. Use of fatty acid nitrogen derivatives in fatty acid halide preparation
JPH041155A (en) * 1989-12-22 1992-01-06 Unichema Chem Bv Production of fatty acid halogenide

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0434389A2 (en) * 1989-12-22 1991-06-26 Unichema Chemie B.V. Use of fatty acid nitrogen derivatives in fatty acid halide preparation
JPH041155A (en) * 1989-12-22 1992-01-06 Unichema Chem Bv Production of fatty acid halogenide

Also Published As

Publication number Publication date
JPS6232181B2 (en) 1987-07-13

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