JPS56103141A - Manufacture of 44*22*dimethylamino**ethoxy** 22methyll55*11methylethyl**phenol ester and its salt - Google Patents
Manufacture of 44*22*dimethylamino**ethoxy** 22methyll55*11methylethyl**phenol ester and its saltInfo
- Publication number
- JPS56103141A JPS56103141A JP17703180A JP17703180A JPS56103141A JP S56103141 A JPS56103141 A JP S56103141A JP 17703180 A JP17703180 A JP 17703180A JP 17703180 A JP17703180 A JP 17703180A JP S56103141 A JPS56103141 A JP S56103141A
- Authority
- JP
- Japan
- Prior art keywords
- dimethylamino
- ethoxy
- salt
- manufacture
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 title abstract 4
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 title 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 phenol ester Chemical class 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 239000000047 product Substances 0.000 abstract 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 abstract 2
- HJGRPZCEBPNMDU-UHFFFAOYSA-N 4-[2-(dimethylamino)ethoxy]-2-methyl-5-propan-2-ylphenol Chemical class CC(C)C1=CC(O)=C(C)C=C1OCCN(C)C HJGRPZCEBPNMDU-UHFFFAOYSA-N 0.000 abstract 1
- 239000005844 Thymol Substances 0.000 abstract 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Substances C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 239000002655 kraft paper Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 229960000790 thymol Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT7928251A IT1209160B (it) | 1979-12-20 | 1979-12-20 | Processo per la sintesi di 4-[2-(dimetilammino)-etossi]2-metil-5-81-metiletil)-fenol-este ri |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56103141A true JPS56103141A (en) | 1981-08-18 |
| JPS6237620B2 JPS6237620B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1987-08-13 |
Family
ID=11223231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17703180A Granted JPS56103141A (en) | 1979-12-20 | 1980-12-15 | Manufacture of 44*22*dimethylamino**ethoxy** 22methyll55*11methylethyl**phenol ester and its salt |
Country Status (6)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0062596B1 (fr) * | 1981-04-06 | 1985-07-03 | Cortial S.A. | Nouveaux dérivés d'aminoéthoxy-4 isopropyl-5 méthyl-2 phénol, leur méthode de préparation et leur emploi en tant que médicaments |
| US5451609A (en) * | 1994-07-27 | 1995-09-19 | Institut De Recherches Chimiques Et Al | Treatment of impotence |
| US6730691B1 (en) | 2000-02-10 | 2004-05-04 | Miles A. Galin | Uses of alpha adrenergic blocking agents |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE905738C (de) * | 1943-06-11 | 1954-11-02 | Diwag Chemische Fabriken Ag | Verfahren zur Herstellung basischer Thymoldimethylaminoaethylaether |
| GB745070A (en) | 1953-04-28 | 1956-02-22 | Veritas Drug Company Ltd | Improvements in or relating to basic thymol dimethyl-amino ethyl ethers |
| FR332F (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-08-08 | 1970-10-19 | ||
| GB1164409A (en) | 1968-08-09 | 1969-09-17 | Claude Dufour | Aminoalkoxy-Carvacrol Derivatives |
| DK138316C (da) | 1972-08-02 | 1979-01-22 | Warner Lambert Co | Analogifremgangsmaade til fremstilling af estere af (beta-(4-hydroxy-thymoxy)ethyl)dimethylamin eller syreadditionssalte deraf |
| US3966779A (en) * | 1973-04-30 | 1976-06-29 | Warner-Lambert Company | Thymol derivatives and a process for their preparation |
| GB1535531A (en) | 1976-10-15 | 1978-12-13 | Warmer & Co Ltd W | Pharmaceutical compositions |
-
1979
- 1979-12-20 IT IT7928251A patent/IT1209160B/it active
-
1980
- 1980-12-04 US US06/212,796 patent/US4336396A/en not_active Expired - Lifetime
- 1980-12-15 JP JP17703180A patent/JPS56103141A/ja active Granted
- 1980-12-15 DE DE8080201200T patent/DE3070872D1/de not_active Expired
- 1980-12-15 EP EP80201200A patent/EP0031184B1/en not_active Expired
- 1980-12-15 AT AT80201200T patent/ATE14214T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IT1209160B (it) | 1989-07-10 |
| JPS6237620B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1987-08-13 |
| IT7928251A0 (it) | 1979-12-20 |
| EP0031184A1 (en) | 1981-07-01 |
| EP0031184B1 (en) | 1985-07-10 |
| DE3070872D1 (en) | 1985-08-14 |
| ATE14214T1 (de) | 1985-07-15 |
| US4336396A (en) | 1982-06-22 |
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