JPS56100785A - 1-azaerythrinan derivative - Google Patents
1-azaerythrinan derivativeInfo
- Publication number
- JPS56100785A JPS56100785A JP381680A JP381680A JPS56100785A JP S56100785 A JPS56100785 A JP S56100785A JP 381680 A JP381680 A JP 381680A JP 381680 A JP381680 A JP 381680A JP S56100785 A JPS56100785 A JP S56100785A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- oxo
- isolated
- lower alkyl
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
NEW MATERIAL:8-Oxo-1-azaerythnan derivatives of formula I [Y is -(CH2)n- (where n is 0, 1), -O-. -S-; R1-3 are H, lower alkoxy, halogen, hydroxyl; R4 is H, lower alkoxycarbonyl, group of formula II (R5, R6 are H, lower alkyl, phenyl)] and their acid adducts. EXAMPLE:8-Oxo-1,11a-diaza-C-homoerythnan. USE:Analgesic: they have an activity of depressing the central nervous system and especially strong analgesic activity. They are useful as a medicine, because of their low toxicity. PREPARATION:A compound of formula III (R7, R8 are lower alkyl) and an amine of formula IV are heated in an inert organic solvent such as benzene, DMF or dioxane to effect condensation reaction. The product is isolated or not isolated and heated under acidic conditions to effect ring closure, thus giving the titled compound of formula I.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP381680A JPS56100785A (en) | 1980-01-16 | 1980-01-16 | 1-azaerythrinan derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP381680A JPS56100785A (en) | 1980-01-16 | 1980-01-16 | 1-azaerythrinan derivative |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP60184445A Division JPS61112084A (en) | 1985-08-21 | 1985-08-21 | 1-azaerythrinane derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56100785A true JPS56100785A (en) | 1981-08-12 |
JPS611024B2 JPS611024B2 (en) | 1986-01-13 |
Family
ID=11567705
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP381680A Granted JPS56100785A (en) | 1980-01-16 | 1980-01-16 | 1-azaerythrinan derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56100785A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4997832A (en) * | 1988-04-20 | 1991-03-05 | Ciba-Geigy Corporation | Heterotetracyclic lactam derivatives |
-
1980
- 1980-01-16 JP JP381680A patent/JPS56100785A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4997832A (en) * | 1988-04-20 | 1991-03-05 | Ciba-Geigy Corporation | Heterotetracyclic lactam derivatives |
Also Published As
Publication number | Publication date |
---|---|
JPS611024B2 (en) | 1986-01-13 |
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