JPS5594636A - Microcapsule for antigen-antibody reaction and detecting method for antigen-antibody reaction using said microcapsule - Google Patents

Microcapsule for antigen-antibody reaction and detecting method for antigen-antibody reaction using said microcapsule

Info

Publication number
JPS5594636A
JPS5594636A JP155579A JP155579A JPS5594636A JP S5594636 A JPS5594636 A JP S5594636A JP 155579 A JP155579 A JP 155579A JP 155579 A JP155579 A JP 155579A JP S5594636 A JPS5594636 A JP S5594636A
Authority
JP
Japan
Prior art keywords
antigen
microcapsule
antibody
antibody reaction
microcapsules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP155579A
Other languages
Japanese (ja)
Other versions
JPS6217709B2 (en
Inventor
Fujio Kakimi
Nobuo Hiratsuka
Kanji Matsukawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Holdings Corp
Original Assignee
Fuji Photo Film Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuji Photo Film Co Ltd filed Critical Fuji Photo Film Co Ltd
Priority to JP155579A priority Critical patent/JPS5594636A/en
Priority to DE19803000483 priority patent/DE3000483A1/en
Priority to US06/110,318 priority patent/US4342739A/en
Priority to GB8000691A priority patent/GB2041517B/en
Publication of JPS5594636A publication Critical patent/JPS5594636A/en
Publication of JPS6217709B2 publication Critical patent/JPS6217709B2/ja
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/30—Magnetic particle immunoreagent carriers the magnetic material being dispersed in the polymer composition before their conversion into particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G01N2446/90—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids characterised by small molecule linker used to couple immunoreagents to magnetic particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

PURPOSE:To obtain an antigen-antibody reaction without dispersion and is strong by a method wherein microcapsule grains are used as carrier grains for combining an antigen and an antibody and the antigen or the antibody is bonded on the surfaces of walls. CONSTITUTION:Microcapsule grains are employed as carriers for combining an antigen and an antibody. When the antigen or the antibody is bonded to microcapsules, wall composition, which is chemically combined without removing the activity of the antigen or the antibody and can be capsulated, is selected as the wall materials of the microcapsules, and bonded by means of methods, such as, an aldehyde bridging method, etc. When the antigen and the antibody are reacted by using the microcapsules, a reaction is obtained which is excellent in accuracy and reproducibility and causes no dispersion.
JP155579A 1979-01-09 1979-01-09 Microcapsule for antigen-antibody reaction and detecting method for antigen-antibody reaction using said microcapsule Granted JPS5594636A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP155579A JPS5594636A (en) 1979-01-09 1979-01-09 Microcapsule for antigen-antibody reaction and detecting method for antigen-antibody reaction using said microcapsule
DE19803000483 DE3000483A1 (en) 1979-01-09 1980-01-08 MICROCAPSULES FOR IMMUNOLOGICAL PROVISIONS
US06/110,318 US4342739A (en) 1979-01-09 1980-01-08 Novel material for immunological assay of biochemical components and a process for the determination of said components
GB8000691A GB2041517B (en) 1979-01-09 1980-01-09 Material and process for immunological assay

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP155579A JPS5594636A (en) 1979-01-09 1979-01-09 Microcapsule for antigen-antibody reaction and detecting method for antigen-antibody reaction using said microcapsule

Publications (2)

Publication Number Publication Date
JPS5594636A true JPS5594636A (en) 1980-07-18
JPS6217709B2 JPS6217709B2 (en) 1987-04-18

Family

ID=11504764

Family Applications (1)

Application Number Title Priority Date Filing Date
JP155579A Granted JPS5594636A (en) 1979-01-09 1979-01-09 Microcapsule for antigen-antibody reaction and detecting method for antigen-antibody reaction using said microcapsule

Country Status (1)

Country Link
JP (1) JPS5594636A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5719660A (en) * 1980-07-09 1982-02-01 Fuji Photo Film Co Ltd Microcapsule for immune reaction
JPS5821565A (en) * 1981-07-31 1983-02-08 Fuji Photo Film Co Ltd Microcapsule for detecting variety of antibody and detection method thereby
JPS5842971A (en) * 1981-09-07 1983-03-12 Fuji Photo Film Co Ltd Microcapsule sensitized with antibody and measuring method of cellular immunity thereby
JPH06230010A (en) * 1993-02-03 1994-08-19 Nitsusui Seiyaku Kk Immunity agglutination reagent and immunity analysis method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3700609A (en) * 1966-04-26 1972-10-24 Ici Australia Ltd Graft copolymers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3700609A (en) * 1966-04-26 1972-10-24 Ici Australia Ltd Graft copolymers

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5719660A (en) * 1980-07-09 1982-02-01 Fuji Photo Film Co Ltd Microcapsule for immune reaction
JPS5821565A (en) * 1981-07-31 1983-02-08 Fuji Photo Film Co Ltd Microcapsule for detecting variety of antibody and detection method thereby
JPH0231348B2 (en) * 1981-07-31 1990-07-12 Fuji Photo Film Co Ltd
JPS5842971A (en) * 1981-09-07 1983-03-12 Fuji Photo Film Co Ltd Microcapsule sensitized with antibody and measuring method of cellular immunity thereby
JPH0449658B2 (en) * 1981-09-07 1992-08-12 Fuji Photo Film Co Ltd
JPH06230010A (en) * 1993-02-03 1994-08-19 Nitsusui Seiyaku Kk Immunity agglutination reagent and immunity analysis method

Also Published As

Publication number Publication date
JPS6217709B2 (en) 1987-04-18

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