JPS559051A - Substituted moranoline derivative - Google Patents

Substituted moranoline derivative

Info

Publication number
JPS559051A
JPS559051A JP8260678A JP8260678A JPS559051A JP S559051 A JPS559051 A JP S559051A JP 8260678 A JP8260678 A JP 8260678A JP 8260678 A JP8260678 A JP 8260678A JP S559051 A JPS559051 A JP S559051A
Authority
JP
Japan
Prior art keywords
polar solvent
hyperglycemia
alkenylene
phenyl
moranoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8260678A
Other languages
Japanese (ja)
Other versions
JPS5943948B2 (en
Inventor
Shingo Matsumura
Hiroshi Enomoto
Yoshiaki Aoyanagi
Yoshiaki Yoshikuni
Kohei Kura
Masahiro Yagi
Ichiro Shirahase
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP8260678A priority Critical patent/JPS5943948B2/en
Priority to GB7909865A priority patent/GB2020278B/en
Priority to DE2915037A priority patent/DE2915037C3/en
Priority to FR7910559A priority patent/FR2424910A1/en
Priority to US06/033,839 priority patent/US4533668A/en
Priority to DK178379A priority patent/DK151623C/en
Priority to IT48904/79A priority patent/IT1116820B/en
Priority to NLAANVRAGE7903421,A priority patent/NL175820C/en
Priority to SE7903817A priority patent/SE436874B/en
Priority to CH415879A priority patent/CH642629A5/en
Publication of JPS559051A publication Critical patent/JPS559051A/en
Priority to AT278581A priority patent/AT371440B/en
Priority to SE8402550A priority patent/SE451016B/en
Priority to SE8402549A priority patent/SE451015B/en
Priority to SE8402551A priority patent/SE451017B/en
Publication of JPS5943948B2 publication Critical patent/JPS5943948B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:N-Substituted moranoline derivative of formula I (Z is II; R is H, phenyl; when R is H, X is 4W5C alkylene, alkenylene; and when R is phenyl, X is 3W5C alkenylene).
USE: A medicine having blood sugar level suppressing activity, and useful as a prophylactic and remedy for hyperglycemia of man and beast, and diseases caused by hyperglycemia, e.g. diabetes, arterioscleroses, obesity, cardiopathy, gastritis, peptic ulcer, duodenal ulcer, etc.
PROCESS: The compound I is prepared by reacting moranoline with a reagent having a reactive aralkyl group or aralkenyl group, e.g. aralkyl halide, in the presence of a proper acid-acceptor, in a solvent such as a polar solvent (e.g. water, various alcohols, dioxane, etc. or their mixture) or an emulsion of the polar solvent and a non-polar solvent such as benzene.
COPYRIGHT: (C)1980,JPO&Japio
JP8260678A 1978-05-03 1978-07-06 Substituted moranoline derivatives Expired JPS5943948B2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
JP8260678A JPS5943948B2 (en) 1978-07-06 1978-07-06 Substituted moranoline derivatives
GB7909865A GB2020278B (en) 1978-05-03 1979-03-21 Moranoline dervitives
DE2915037A DE2915037C3 (en) 1978-05-03 1979-04-12 New N-substituted moranoline derivatives
FR7910559A FR2424910A1 (en) 1978-05-03 1979-04-25 MORANOLINE N-SUBSTITUTES DERIVATIVES AND THEIR USE, IN PARTICULAR FOR THE TREATMENT OF HYPERGLYCEMIA
US06/033,839 US4533668A (en) 1978-05-03 1979-04-27 Antihyperglycemic moranoline derivatives
DK178379A DK151623C (en) 1978-05-03 1979-05-01 METHOD OF ANALOGUE FOR THE PREPARATION OF N-SUBSTITUTED MORANOLINE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.
NLAANVRAGE7903421,A NL175820C (en) 1978-05-03 1979-05-02 N-SUBSTITUTED MORANOLINE DERIVATIVES, METHOD FOR PREPARING A MEDICINAL PRODUCT THEREFROM, AND MEDICINAL PRODUCT OBTAINED THEREFORE.
IT48904/79A IT1116820B (en) 1978-05-03 1979-05-02 MORANOLINA DERIVATIVES WITH PHARMACOLOGICAL PROPERTIES
SE7903817A SE436874B (en) 1978-05-03 1979-05-02 N-SUBSTITUTED MORANOLINE DERIVATIVES
CH415879A CH642629A5 (en) 1978-05-03 1979-05-03 MORANOLINE DERIVATIVES SUBSTITUTED ON NITROGEN ATOM.
AT278581A AT371440B (en) 1978-07-06 1981-06-23 METHOD FOR PRODUCING NEW N-SUBSTITUTED MORANOLINE DERIVATIVES AND THEIR ACID ADDITION SALTS
SE8402550A SE451016B (en) 1978-05-03 1984-05-11 N-SUBSTITUTED MORANOLINE DERIVATIVES
SE8402549A SE451015B (en) 1978-05-03 1984-05-11 SUBSTITUTED MORANOLINE DERIVATIVES
SE8402551A SE451017B (en) 1978-05-03 1984-05-11 CINNAMYLMORANOLIN DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8260678A JPS5943948B2 (en) 1978-07-06 1978-07-06 Substituted moranoline derivatives

Publications (2)

Publication Number Publication Date
JPS559051A true JPS559051A (en) 1980-01-22
JPS5943948B2 JPS5943948B2 (en) 1984-10-25

Family

ID=13779127

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8260678A Expired JPS5943948B2 (en) 1978-05-03 1978-07-06 Substituted moranoline derivatives

Country Status (1)

Country Link
JP (1) JPS5943948B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5446786A (en) * 1977-08-27 1979-04-12 Bayer Ag Novel 3*4*55trihydroxypiperidine compound* its manufacture and use for medicine
JP2009538336A (en) * 2006-05-24 2009-11-05 ユナイテッド セラピューティクス コーポレーション Deoxynojirimycin and D-arabinitol analogs and methods of use

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5446786A (en) * 1977-08-27 1979-04-12 Bayer Ag Novel 3*4*55trihydroxypiperidine compound* its manufacture and use for medicine
JPS6231703B2 (en) * 1977-08-27 1987-07-09 Bayer Ag
JP2009538336A (en) * 2006-05-24 2009-11-05 ユナイテッド セラピューティクス コーポレーション Deoxynojirimycin and D-arabinitol analogs and methods of use

Also Published As

Publication number Publication date
JPS5943948B2 (en) 1984-10-25

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