JPS5583794A - Novel phosphinic acid derivative and antilipemic agent comprising it - Google Patents

Novel phosphinic acid derivative and antilipemic agent comprising it

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Publication number
JPS5583794A
JPS5583794A JP15688178A JP15688178A JPS5583794A JP S5583794 A JPS5583794 A JP S5583794A JP 15688178 A JP15688178 A JP 15688178A JP 15688178 A JP15688178 A JP 15688178A JP S5583794 A JPS5583794 A JP S5583794A
Authority
JP
Japan
Prior art keywords
formula
compound
acid derivative
phosphinic acid
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15688178A
Other languages
Japanese (ja)
Inventor
Takashi Tsuruoka
Tetsutarou Niiguro
Akira Suzuki
Kazuko Mizutani
Shigeharu Inoue
Takemi Koeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Priority to JP15688178A priority Critical patent/JPS5583794A/en
Publication of JPS5583794A publication Critical patent/JPS5583794A/en
Pending legal-status Critical Current

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Abstract

NEW MATERIAL:A phosphinic acid derivative of formula I [R1 is alkyl group or formula II (R3 is H, alkyl group, etc.); R2 is H, alkyl, phenyl group, etc.; n is an integer 1W5], and its salt.
EXAMPLE: 3-(Hydroxyamino)propyl phenylphosphinate.
USE: Antilipemic agents for preventing and treating hyperlipemia and arteriosclerosis.
PROCESS: A compound of formula III (X is halogen; R4 is alkyl group) is reacted with a compound of formula IV (R5 is benzyl, alkoxycarbonyl group, etc.; R6 is benzenesulfonyl, p-toluene-sulfonyl group, etc.) in the presence of a base, e.g. NaOH or pyridine, in an organic solvent, e.g. methanol or DMF, to give the compound of formula V, which is then hydrolyzed and N-acylated to form the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP15688178A 1978-12-21 1978-12-21 Novel phosphinic acid derivative and antilipemic agent comprising it Pending JPS5583794A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15688178A JPS5583794A (en) 1978-12-21 1978-12-21 Novel phosphinic acid derivative and antilipemic agent comprising it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15688178A JPS5583794A (en) 1978-12-21 1978-12-21 Novel phosphinic acid derivative and antilipemic agent comprising it

Publications (1)

Publication Number Publication Date
JPS5583794A true JPS5583794A (en) 1980-06-24

Family

ID=15637423

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15688178A Pending JPS5583794A (en) 1978-12-21 1978-12-21 Novel phosphinic acid derivative and antilipemic agent comprising it

Country Status (1)

Country Link
JP (1) JPS5583794A (en)

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