JPS5583794A - Novel phosphinic acid derivative and antilipemic agent comprising it - Google Patents
Novel phosphinic acid derivative and antilipemic agent comprising itInfo
- Publication number
- JPS5583794A JPS5583794A JP15688178A JP15688178A JPS5583794A JP S5583794 A JPS5583794 A JP S5583794A JP 15688178 A JP15688178 A JP 15688178A JP 15688178 A JP15688178 A JP 15688178A JP S5583794 A JPS5583794 A JP S5583794A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- acid derivative
- phosphinic acid
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A phosphinic acid derivative of formula I [R1 is alkyl group or formula II (R3 is H, alkyl group, etc.); R2 is H, alkyl, phenyl group, etc.; n is an integer 1W5], and its salt.
EXAMPLE: 3-(Hydroxyamino)propyl phenylphosphinate.
USE: Antilipemic agents for preventing and treating hyperlipemia and arteriosclerosis.
PROCESS: A compound of formula III (X is halogen; R4 is alkyl group) is reacted with a compound of formula IV (R5 is benzyl, alkoxycarbonyl group, etc.; R6 is benzenesulfonyl, p-toluene-sulfonyl group, etc.) in the presence of a base, e.g. NaOH or pyridine, in an organic solvent, e.g. methanol or DMF, to give the compound of formula V, which is then hydrolyzed and N-acylated to form the compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15688178A JPS5583794A (en) | 1978-12-21 | 1978-12-21 | Novel phosphinic acid derivative and antilipemic agent comprising it |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15688178A JPS5583794A (en) | 1978-12-21 | 1978-12-21 | Novel phosphinic acid derivative and antilipemic agent comprising it |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5583794A true JPS5583794A (en) | 1980-06-24 |
Family
ID=15637423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15688178A Pending JPS5583794A (en) | 1978-12-21 | 1978-12-21 | Novel phosphinic acid derivative and antilipemic agent comprising it |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5583794A (en) |
-
1978
- 1978-12-21 JP JP15688178A patent/JPS5583794A/en active Pending
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