JPS5579376A - Novel 1-phthalazone derivative - Google Patents

Novel 1-phthalazone derivative

Info

Publication number
JPS5579376A
JPS5579376A JP15262078A JP15262078A JPS5579376A JP S5579376 A JPS5579376 A JP S5579376A JP 15262078 A JP15262078 A JP 15262078A JP 15262078 A JP15262078 A JP 15262078A JP S5579376 A JPS5579376 A JP S5579376A
Authority
JP
Japan
Prior art keywords
compound
alkyl
phenyl
phthalazone
pyridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15262078A
Other languages
Japanese (ja)
Inventor
Masayuki Ishikawa
Masao Eguchi
Hiromichi Tanaka
Shigeru Ito
Yoshimi Takashima
Masahiko Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP15262078A priority Critical patent/JPS5579376A/en
Publication of JPS5579376A publication Critical patent/JPS5579376A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A 1-phthalazone derivative of formula I (R1,2 are lower alkyl; R3 is alkyl; R4 is alkyl or phenyl; R5 is alkyl, alkoxy, phenyl or pyridyl; R is H, phenyl, pyridyl, etc.).
EXAMPLE: The compound of formula II.
USE: An agent having thromboxan A2 antagonistic activity, and useful for the prevention and remedy of arteriosclerosis, thrombosis, ischemic cerebral vascular lesion, and ischemic cardiopathy.
PROCESS: The compound I is prepared by reacting a compound III (e.g. 7-ethoxycarbonyl-6,8-dimethyl-4-formyl-1-phthalazone) with a compound IV [e.g. (methylsulfonyl)-acetone] in a solvent such as benzene, in the presence of a catalyst such as pyridine, at 50W150°C, esp. 80W120°C.
COPYRIGHT: (C)1980,JPO&Japio
JP15262078A 1978-12-12 1978-12-12 Novel 1-phthalazone derivative Pending JPS5579376A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15262078A JPS5579376A (en) 1978-12-12 1978-12-12 Novel 1-phthalazone derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15262078A JPS5579376A (en) 1978-12-12 1978-12-12 Novel 1-phthalazone derivative

Publications (1)

Publication Number Publication Date
JPS5579376A true JPS5579376A (en) 1980-06-14

Family

ID=15544351

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15262078A Pending JPS5579376A (en) 1978-12-12 1978-12-12 Novel 1-phthalazone derivative

Country Status (1)

Country Link
JP (1) JPS5579376A (en)

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