JPS5557584A - Preparation of 1'-methyl-2'-(3-pyridyl)-2'-pyrroline - Google Patents
Preparation of 1'-methyl-2'-(3-pyridyl)-2'-pyrrolineInfo
- Publication number
- JPS5557584A JPS5557584A JP13047878A JP13047878A JPS5557584A JP S5557584 A JPS5557584 A JP S5557584A JP 13047878 A JP13047878 A JP 13047878A JP 13047878 A JP13047878 A JP 13047878A JP S5557584 A JPS5557584 A JP S5557584A
- Authority
- JP
- Japan
- Prior art keywords
- benzene
- residue
- organic solvent
- solvent
- pyridyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare the title compound useful as an intermediate of a nictotine derivative, in high efficiency, by extracting an alkaline aqueous solution of pseudoxyniotine with a non-aqueous organic solvent, removing the solvent from the extract, and refluxing the residue with benzene.
CONSTITUTION: 1'-( 3-Pyridyl )-4'-methylaminobutan-1'-one ( Pseudoxynicotine ) hydrochloride is dissolved in water, and adjusted its pH to pref. ≥12 by adding an alkali. The solution is extracted with a non-aqueous organic solvent such as chloroform, and dehydrated by adding a dehydrating agent to the solvent phase, and the organic solvent is removed under reduced pressure. The residue is dissolved in benzene, and refluxed under atmospheric pressure to remove the water completely from the residue. Benzene is distilled off under atmospheric pressure to obtain the objective N-methylmyosmine.
EFFECT: Free from resin formation by distillation.
USE: Medicine, pesticide, an agent for improving taste and flavor of tobacco., etc.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13047878A JPS5557584A (en) | 1978-10-25 | 1978-10-25 | Preparation of 1'-methyl-2'-(3-pyridyl)-2'-pyrroline |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13047878A JPS5557584A (en) | 1978-10-25 | 1978-10-25 | Preparation of 1'-methyl-2'-(3-pyridyl)-2'-pyrroline |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5557584A true JPS5557584A (en) | 1980-04-28 |
JPS566427B2 JPS566427B2 (en) | 1981-02-10 |
Family
ID=15035199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13047878A Granted JPS5557584A (en) | 1978-10-25 | 1978-10-25 | Preparation of 1'-methyl-2'-(3-pyridyl)-2'-pyrroline |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5557584A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5726750A (en) * | 1980-07-25 | 1982-02-12 | Nippon Koutai Kenkyusho:Kk | Metod for determining side chain of cancer-concerned saccharide and method for diagnosing cancer and kit for diagnosis of cancer |
JPS5729951A (en) * | 1980-07-30 | 1982-02-18 | Nippon Koutai Kenkyusho:Kk | Determintion of sugar side chain related to cancer |
CN107011321A (en) * | 2017-03-27 | 2017-08-04 | 华健 | A kind of preparation method of artificial synthesized raceme nicotine |
CN112876454A (en) * | 2020-03-25 | 2021-06-01 | 深圳梵活生命科学股份有限公司 | Preparation method of artificially synthesized (R, S) -nicotine salt |
-
1978
- 1978-10-25 JP JP13047878A patent/JPS5557584A/en active Granted
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5726750A (en) * | 1980-07-25 | 1982-02-12 | Nippon Koutai Kenkyusho:Kk | Metod for determining side chain of cancer-concerned saccharide and method for diagnosing cancer and kit for diagnosis of cancer |
JPS5729951A (en) * | 1980-07-30 | 1982-02-18 | Nippon Koutai Kenkyusho:Kk | Determintion of sugar side chain related to cancer |
CN107011321A (en) * | 2017-03-27 | 2017-08-04 | 华健 | A kind of preparation method of artificial synthesized raceme nicotine |
CN112876454A (en) * | 2020-03-25 | 2021-06-01 | 深圳梵活生命科学股份有限公司 | Preparation method of artificially synthesized (R, S) -nicotine salt |
Also Published As
Publication number | Publication date |
---|---|
JPS566427B2 (en) | 1981-02-10 |
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