JPS5557584A - Preparation of 1'-methyl-2'-(3-pyridyl)-2'-pyrroline - Google Patents

Preparation of 1'-methyl-2'-(3-pyridyl)-2'-pyrroline

Info

Publication number
JPS5557584A
JPS5557584A JP13047878A JP13047878A JPS5557584A JP S5557584 A JPS5557584 A JP S5557584A JP 13047878 A JP13047878 A JP 13047878A JP 13047878 A JP13047878 A JP 13047878A JP S5557584 A JPS5557584 A JP S5557584A
Authority
JP
Japan
Prior art keywords
benzene
residue
organic solvent
solvent
pyridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13047878A
Other languages
Japanese (ja)
Other versions
JPS566427B2 (en
Inventor
Takuro Kisaki
Yoichi Mikami
Susumu Maeda
Hajime Matsushita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Tobacco Inc
Original Assignee
Japan Tobacco Inc
Japan Tobacco and Salt Public Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc, Japan Tobacco and Salt Public Corp filed Critical Japan Tobacco Inc
Priority to JP13047878A priority Critical patent/JPS5557584A/en
Publication of JPS5557584A publication Critical patent/JPS5557584A/en
Publication of JPS566427B2 publication Critical patent/JPS566427B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the title compound useful as an intermediate of a nictotine derivative, in high efficiency, by extracting an alkaline aqueous solution of pseudoxyniotine with a non-aqueous organic solvent, removing the solvent from the extract, and refluxing the residue with benzene.
CONSTITUTION: 1'-( 3-Pyridyl )-4'-methylaminobutan-1'-one ( Pseudoxynicotine ) hydrochloride is dissolved in water, and adjusted its pH to pref. ≥12 by adding an alkali. The solution is extracted with a non-aqueous organic solvent such as chloroform, and dehydrated by adding a dehydrating agent to the solvent phase, and the organic solvent is removed under reduced pressure. The residue is dissolved in benzene, and refluxed under atmospheric pressure to remove the water completely from the residue. Benzene is distilled off under atmospheric pressure to obtain the objective N-methylmyosmine.
EFFECT: Free from resin formation by distillation.
USE: Medicine, pesticide, an agent for improving taste and flavor of tobacco., etc.
COPYRIGHT: (C)1980,JPO&Japio
JP13047878A 1978-10-25 1978-10-25 Preparation of 1'-methyl-2'-(3-pyridyl)-2'-pyrroline Granted JPS5557584A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13047878A JPS5557584A (en) 1978-10-25 1978-10-25 Preparation of 1'-methyl-2'-(3-pyridyl)-2'-pyrroline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13047878A JPS5557584A (en) 1978-10-25 1978-10-25 Preparation of 1'-methyl-2'-(3-pyridyl)-2'-pyrroline

Publications (2)

Publication Number Publication Date
JPS5557584A true JPS5557584A (en) 1980-04-28
JPS566427B2 JPS566427B2 (en) 1981-02-10

Family

ID=15035199

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13047878A Granted JPS5557584A (en) 1978-10-25 1978-10-25 Preparation of 1'-methyl-2'-(3-pyridyl)-2'-pyrroline

Country Status (1)

Country Link
JP (1) JPS5557584A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5726750A (en) * 1980-07-25 1982-02-12 Nippon Koutai Kenkyusho:Kk Metod for determining side chain of cancer-concerned saccharide and method for diagnosing cancer and kit for diagnosis of cancer
JPS5729951A (en) * 1980-07-30 1982-02-18 Nippon Koutai Kenkyusho:Kk Determintion of sugar side chain related to cancer
CN107011321A (en) * 2017-03-27 2017-08-04 华健 A kind of preparation method of artificial synthesized raceme nicotine
CN112876454A (en) * 2020-03-25 2021-06-01 深圳梵活生命科学股份有限公司 Preparation method of artificially synthesized (R, S) -nicotine salt

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5726750A (en) * 1980-07-25 1982-02-12 Nippon Koutai Kenkyusho:Kk Metod for determining side chain of cancer-concerned saccharide and method for diagnosing cancer and kit for diagnosis of cancer
JPS5729951A (en) * 1980-07-30 1982-02-18 Nippon Koutai Kenkyusho:Kk Determintion of sugar side chain related to cancer
CN107011321A (en) * 2017-03-27 2017-08-04 华健 A kind of preparation method of artificial synthesized raceme nicotine
CN112876454A (en) * 2020-03-25 2021-06-01 深圳梵活生命科学股份有限公司 Preparation method of artificially synthesized (R, S) -nicotine salt

Also Published As

Publication number Publication date
JPS566427B2 (en) 1981-02-10

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