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Ajinomoto Co Inc
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Ajinomoto Co Inc
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Application filed by Ajinomoto Co IncfiledCriticalAjinomoto Co Inc
Priority to JP13117778ApriorityCriticalpatent/JPS5557548A/en
Publication of JPS5557548ApublicationCriticalpatent/JPS5557548A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
PURPOSE: To obtain the title compound by the easy racemization of optically active Nα-acylamino acid with an acitve ester of aliphatic acid in the presence of a tertiary amine and 1-hydroxybenzotriazole (HOBT).
CONSTITUTION: The title compound is obtained by the reaction of an optically active Nα-acylamino acid with an active ester of aliphatic acid at room temp.W 100°C in the presence of a tertiary amine (example; triethyl amine, etc.) and 1- hydroxybenzotriazole (HOBT) using a solvent, e.g. DMSO. Preferable amino acid of the optically active Nα-acylamino acid is natural or synthetic and neutral, acidic or basic amino acid. The acyl group is, e.g. benzoyl groups, formyl groups, etc. This invention is useful for the racemization of residual amino acids after the separation of the desired optically active amino acid in the amino acid resolution with acylase.
COPYRIGHT: (C)1980,JPO&Japio
JP13117778A1978-10-251978-10-25Preparation of nalpha-acyl-dl-amino acid
PendingJPS5557548A
(en)