JPS5542536A - Preparation of antibiotic substance ns-5 - Google Patents

Preparation of antibiotic substance ns-5

Info

Publication number
JPS5542536A
JPS5542536A JP11532578A JP11532578A JPS5542536A JP S5542536 A JPS5542536 A JP S5542536A JP 11532578 A JP11532578 A JP 11532578A JP 11532578 A JP11532578 A JP 11532578A JP S5542536 A JPS5542536 A JP S5542536A
Authority
JP
Japan
Prior art keywords
antibiotic substance
aminoacylase
gram
preparation
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11532578A
Other languages
Japanese (ja)
Inventor
Katsuro Kubo
Yasuo Fukagawa
Tomoyuki Ishikura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanraku Inc
Sanraku Ocean Co Ltd
Original Assignee
Sanraku Inc
Sanraku Ocean Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanraku Inc, Sanraku Ocean Co Ltd filed Critical Sanraku Inc
Priority to JP11532578A priority Critical patent/JPS5542536A/en
Publication of JPS5542536A publication Critical patent/JPS5542536A/en
Pending legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PURPOSE: To prepare antibiotic substance NS-5, i.e. N-desacetyl PS-5, by reacting an antibiotic substance PS-5 with an enzyme.
CONSTITUTION: Antibiotic substance PS-5 (Japanese patent application Nos. 52- 35375 and 52-94651) is converted to antibiotic substance NS-5 by treating with L-aminoacylase or D-aminoacylase. The antibiotic substance NS-5 has strong antibacterial activity to gram-positive and gram-negative bacteria, and especially, stronger activity to Staphylococcus than PS-5. It is also important as a raw material of PS-5 derivatives. The reaction is carried out by dissolving the PS-5 in a 5mM phosphate buffer solution having a pH value of 8.0, and contacting with a solution of L- or D-aminoacylase at pH 6W8.5, pref. 7W8, at 30°C for 1W20 hours.
COPYRIGHT: (C)1980,JPO&Japio
JP11532578A 1978-09-19 1978-09-19 Preparation of antibiotic substance ns-5 Pending JPS5542536A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11532578A JPS5542536A (en) 1978-09-19 1978-09-19 Preparation of antibiotic substance ns-5

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11532578A JPS5542536A (en) 1978-09-19 1978-09-19 Preparation of antibiotic substance ns-5

Publications (1)

Publication Number Publication Date
JPS5542536A true JPS5542536A (en) 1980-03-25

Family

ID=14659771

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11532578A Pending JPS5542536A (en) 1978-09-19 1978-09-19 Preparation of antibiotic substance ns-5

Country Status (1)

Country Link
JP (1) JPS5542536A (en)

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