JPS5535060A - Asymmetric hydrogenation of alpha-keto-acid ester - Google Patents

Asymmetric hydrogenation of alpha-keto-acid ester

Info

Publication number
JPS5535060A
JPS5535060A JP10896478A JP10896478A JPS5535060A JP S5535060 A JPS5535060 A JP S5535060A JP 10896478 A JP10896478 A JP 10896478A JP 10896478 A JP10896478 A JP 10896478A JP S5535060 A JPS5535060 A JP S5535060A
Authority
JP
Japan
Prior art keywords
keto
acid ester
asymmetry
alpha
platinum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10896478A
Other languages
Japanese (ja)
Other versions
JPS5742619B2 (en
Inventor
Yoshiro Orito
Sumi Imai
Shuichi Niwa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institute of Advanced Industrial Science and Technology AIST
Original Assignee
Agency of Industrial Science and Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency of Industrial Science and Technology filed Critical Agency of Industrial Science and Technology
Priority to JP10896478A priority Critical patent/JPS5535060A/en
Publication of JPS5535060A publication Critical patent/JPS5535060A/en
Publication of JPS5742619B2 publication Critical patent/JPS5742619B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the title substance, e.g. an optically active lactate, useful as a raw material for medicines with a high degree of asymmetry, by hydrogenating an α-Keto-acid ester in the presence of a modified solid catalyst, which is readily prepared and handled.
CONSTITUTION: An α-keto-acid ester is hydrogenated asymmetrically in the presence a modified platinum-carbon catalyst, which is prepared by dissolving quinine (-), quinidine (+), or cinchonine in THF, etc., and by immersing the platinum- carbon catalyst in the 0.5W3% solution thus obtained for several hours to adsorb the alkaloid fully, in a solvent, e.g. an alcohol under a hydrogen pressure of several to 100atm. The small amount of the same cinchona-alkaloid used for modification in the solvent improves the degree of asymmetry.
COPYRIGHT: (C)1980,JPO&Japio
JP10896478A 1978-09-05 1978-09-05 Asymmetric hydrogenation of alpha-keto-acid ester Granted JPS5535060A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10896478A JPS5535060A (en) 1978-09-05 1978-09-05 Asymmetric hydrogenation of alpha-keto-acid ester

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10896478A JPS5535060A (en) 1978-09-05 1978-09-05 Asymmetric hydrogenation of alpha-keto-acid ester

Publications (2)

Publication Number Publication Date
JPS5535060A true JPS5535060A (en) 1980-03-11
JPS5742619B2 JPS5742619B2 (en) 1982-09-09

Family

ID=14498116

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10896478A Granted JPS5535060A (en) 1978-09-05 1978-09-05 Asymmetric hydrogenation of alpha-keto-acid ester

Country Status (1)

Country Link
JP (1) JPS5535060A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
EP1063224A1 (en) * 1999-06-23 2000-12-27 F. Hoffmann-La Roche Ag Continuous hydrogenation process

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
EP1063224A1 (en) * 1999-06-23 2000-12-27 F. Hoffmann-La Roche Ag Continuous hydrogenation process
US6646135B1 (en) 1999-06-23 2003-11-11 Roche Vitamins Inc. Continuous process for the enantioselective hydrogenation of alpha ketocarbonyl compounds

Also Published As

Publication number Publication date
JPS5742619B2 (en) 1982-09-09

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