JPS5534082A - Stabilization of urokinase - Google Patents
Stabilization of urokinaseInfo
- Publication number
- JPS5534082A JPS5534082A JP10873878A JP10873878A JPS5534082A JP S5534082 A JPS5534082 A JP S5534082A JP 10873878 A JP10873878 A JP 10873878A JP 10873878 A JP10873878 A JP 10873878A JP S5534082 A JPS5534082 A JP S5534082A
- Authority
- JP
- Japan
- Prior art keywords
- urokinase
- added
- dextran sulfate
- stabilization
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Enzymes And Modification Thereof (AREA)
Abstract
PURPOSE: To a powder or solution of urokinase that is used as a remedy for cerebral thrombosis are added dextran sulfate and an inert protein, thus stabilizing the urokinase and increasing the formability in the preparation process.
CONSTITUTION: To urakinase are added, as stabilizers, (A) dextran sulfate and (B) an inert protein. The most effective dextran sulfate in the stabilization of urokinase is its sodium salt. The average molecular weight is desirably in the range from 103 to 106 and preferably from 1500 to 80,000. The sulfur content is 1W30, preferably 2W15%. The inert protein means protein that has no activity of enzyme or hormon, such as gelatin. They are added by 0.1W50mg/103PU of (A) and 0.01W 30mg/PU of (B) in the extraction and purificastion processes and 0.1W10mg/103PU of (A) and 0.31W5mg/103PU in the preparation process.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10873878A JPS5534082A (en) | 1978-09-04 | 1978-09-04 | Stabilization of urokinase |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10873878A JPS5534082A (en) | 1978-09-04 | 1978-09-04 | Stabilization of urokinase |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5534082A true JPS5534082A (en) | 1980-03-10 |
Family
ID=14492265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10873878A Pending JPS5534082A (en) | 1978-09-04 | 1978-09-04 | Stabilization of urokinase |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5534082A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100346180B1 (en) * | 1999-07-14 | 2002-07-26 | 제일제당주식회사 | Method and composition for increasing stability and activity of enzymes |
EP2223708A2 (en) | 2009-02-25 | 2010-09-01 | Teleflex Medical Incorporated | Stabilized enzyme compositions |
WO2015048619A2 (en) | 2013-09-30 | 2015-04-02 | Teleflex Medical Incorporated | Stabilized enzyme compositions |
US9333280B2 (en) | 2009-02-25 | 2016-05-10 | Teleflex Medical Incorporated | Stabilized enzyme compositions |
-
1978
- 1978-09-04 JP JP10873878A patent/JPS5534082A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100346180B1 (en) * | 1999-07-14 | 2002-07-26 | 제일제당주식회사 | Method and composition for increasing stability and activity of enzymes |
EP2223708A2 (en) | 2009-02-25 | 2010-09-01 | Teleflex Medical Incorporated | Stabilized enzyme compositions |
US8545459B2 (en) | 2009-02-25 | 2013-10-01 | Teleflex Medical Incorporated | Stabilized enzyme compositions |
US9333280B2 (en) | 2009-02-25 | 2016-05-10 | Teleflex Medical Incorporated | Stabilized enzyme compositions |
WO2015048619A2 (en) | 2013-09-30 | 2015-04-02 | Teleflex Medical Incorporated | Stabilized enzyme compositions |
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