JPS5531090A - Fluorinated polyene compound - Google Patents

Fluorinated polyene compound

Info

Publication number
JPS5531090A
JPS5531090A JP10612479A JP10612479A JPS5531090A JP S5531090 A JPS5531090 A JP S5531090A JP 10612479 A JP10612479 A JP 10612479A JP 10612479 A JP10612479 A JP 10612479A JP S5531090 A JPS5531090 A JP S5531090A
Authority
JP
Japan
Prior art keywords
polyene compound
fluorinated
substituted
fluorinated polyene
acne
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10612479A
Other languages
English (en)
Other versions
JPS6252732B2 (ja
Inventor
Chiyan Kaakon
An Pooson Bebarii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JPS5531090A publication Critical patent/JPS5531090A/ja
Publication of JPS6252732B2 publication Critical patent/JPS6252732B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/42—Singly bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483—Monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Cosmetics (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
JP10612479A 1978-08-24 1979-08-22 Fluorinated polyene compound Granted JPS5531090A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/936,466 US4171318A (en) 1978-08-24 1978-08-24 Fluorinated polyenes

Publications (2)

Publication Number Publication Date
JPS5531090A true JPS5531090A (en) 1980-03-05
JPS6252732B2 JPS6252732B2 (ja) 1987-11-06

Family

ID=25468684

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10612479A Granted JPS5531090A (en) 1978-08-24 1979-08-22 Fluorinated polyene compound

Country Status (13)

Country Link
US (1) US4171318A (ja)
EP (1) EP0009539B1 (ja)
JP (1) JPS5531090A (ja)
AT (1) ATE2064T1 (ja)
AU (1) AU530952B2 (ja)
CA (1) CA1123442A (ja)
DE (1) DE2964350D1 (ja)
DK (1) DK352779A (ja)
IE (1) IE48809B1 (ja)
IL (1) IL58064A (ja)
NZ (1) NZ191345A (ja)
PH (2) PH16422A (ja)
ZA (1) ZA794334B (ja)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4476056A (en) * 1982-11-05 1984-10-09 Hoffmann-La Roche Inc. Trifluoromethoxy analogs of aromatic retinoids
FR2650825B1 (fr) * 1989-08-11 1991-12-06 Isochem Sa Nouvelle pyranone, procede pour sa preparation, son application a la preparation d'une nouvelle pyridinone et son procede de preparation
US6506917B1 (en) * 1991-12-18 2003-01-14 The Salk Institute For Biological Studies Compounds and compositions useful for modulation of processes mediated by RXR
US5286895A (en) * 1992-02-19 1994-02-15 Merck & Co., Inc. Cholesterol lowering compounds
US5508456A (en) * 1993-07-30 1996-04-16 Ligand Pharmaceuticals Incorporated 9-cis tritium-labeled retinoids and intermediates, methods for their synthesis and methods for their use in discovering retinoid X receptor ligands
US5534261A (en) * 1995-01-17 1996-07-09 University Of Southern California Retinoid-based compositions and method for preventing adhesion formation using the same
US8026280B2 (en) 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7842727B2 (en) 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US6495719B2 (en) 2001-03-27 2002-12-17 Circagen Pharmaceutical Histone deacetylase inhibitors
EP1511477A4 (en) 2002-05-22 2008-04-09 Errant Gene Therapeutics Llc HISTONE DEACETYLASE INHIBITORS BASED ON ALPHA-KETO-EPOXYDE COMPOUNDS
EP1567142A4 (en) * 2002-11-20 2005-12-14 Errant Gene Therapeutics Llc TREATMENT OF PULMONARY CELLS WITH HISTONE DEACETYLASE INHIBITORS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883508A (en) * 1973-06-13 1975-05-13 Hoffmann La Roche Process for the preparation of guanosine tetra- and penta-phosphates and products
US4054589A (en) * 1974-09-26 1977-10-18 Hoffmann-La Roche Inc. Novel 9-substituted phenyl-3,7-dimethyl-nona-2,4,6,8-tetraene esters
US4061656A (en) * 1975-11-14 1977-12-06 Hoffmann-La Roche Inc. Polyene compounds
CH624373A5 (en) * 1975-11-14 1981-07-31 Hoffmann La Roche Process for the preparation of polyene compounds
GB1560699A (en) * 1975-11-14 1980-02-06 Hoffmann La Roche 2-or 3-thienyl-polyenes
CA1111441A (en) * 1976-12-20 1981-10-27 Werner Bollag Polyene compounds

Also Published As

Publication number Publication date
PH16422A (en) 1983-10-03
JPS6252732B2 (ja) 1987-11-06
US4171318A (en) 1979-10-16
DE2964350D1 (en) 1983-01-27
AU530952B2 (en) 1983-08-04
PH17473A (en) 1984-08-29
ATE2064T1 (de) 1983-01-15
ZA794334B (en) 1980-08-27
AU5026579A (en) 1980-02-28
NZ191345A (en) 1984-07-06
CA1123442A (en) 1982-05-11
IL58064A (en) 1984-10-31
EP0009539B1 (en) 1982-12-22
EP0009539A1 (en) 1980-04-16
DK352779A (da) 1980-03-31
IE48809B1 (en) 1985-05-29
IL58064A0 (en) 1979-12-30
IE791614L (en) 1980-02-24

Similar Documents

Publication Publication Date Title
JPS5531090A (en) Fluorinated polyene compound
DK554084A (da) 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol
CS190341B2 (en) Method of producing new derivatives of 2,3-dihydro-imidazo/2,1-b/thiazole
MX5901E (es) Procedimiento mejorado para incrementar el rendimiento de urocinasa en un metodo para la produccion de dicha urocinasa
IT7926964A0 (it) Procedimento per la produzione di derivati dell'acido fenossicarbossilico.
AU560500B2 (en) Polyenes
ATE2444T1 (de) Verfahren zur herstellung von cyclohexenderivaten.
ZA776519B (en) Process for the production of 9-(b-d-arabinofuranosyl)adenine,5'-phosphate
HU186343B (en) Pungicide preparations containing 2,3,6-trisubsituted-n-acyl-anilide derivatives as actor as well as method for producing the actors
IT1156732B (it) Derivati sostituiti dell'1,3-diidroimidazo(4,5-b)piridin-2-one e relativo procedimento di produzione
IT7924851A0 (it) Derivati di idrochinone e relativo procedimento per la loro produzione.
SU1178325A3 (ru) "cпocoб пoлучehия пpoизboдhыx 2,2-диaлkил-18,19-диhopпpeгh-4-eh-3,20-диoha"
JPS54160639A (en) Monokaryon producing method by dedikaryotizing basidiomycete dikaryon fungus roots
BR7608664A (pt) Processo para preparar 1,1-dihalo-4-metil-1,3-pentadienos,processo para preparar uma olefina,e composto
GB1554095A (en) Method of producing 5-nitroso-2,4,6-triaminopyrimidine
IT7926564A0 (it) Nuovi derivati 1,6-naftiridinici, procedimento per la loro produzione, nonche' farmaci antidinici e che migliorano la circolazione cerebrale contenenti tali derivati.
DE2964718D1 (en) Process for the preparation of 7-oxabicyclo(4.1.0)heptane-3,4-dicarboxylic acid diglycidyl ester
JPS6485019A (en) Method for cultivating plant
IT1163712B (it) Azocomposti antrachinonici, processo per la loro produzione e loro impiego come coloranti
JPS5221176A (en) Box for driving away harmful birds
JPS5330181A (en) Wiring plate for lighting apparatus
MA19333A1 (fr) Nouveau procede de preparation de derives de la tetrahydro- 5-6-7-7a-4h- thieno (3,2-c) pyridinone -2.
IT7927508A0 (it) Procedimento per produrre ruote per veicoli leggeri e ruote prodotte secondo questo procedimento.
IL58133A0 (en) (n-methylcarbamoyl-phenoxy)-(n',n'',n''-trialkyl-urea-n,n'sulfide derivatives their production and their use as insecticides
BR7908434A (pt) Process para producao de 2,4-dinitrofenil-ureia