JPS5519209A - Adamantane derivative and its preparation - Google Patents

Adamantane derivative and its preparation

Info

Publication number
JPS5519209A
JPS5519209A JP9050578A JP9050578A JPS5519209A JP S5519209 A JPS5519209 A JP S5519209A JP 9050578 A JP9050578 A JP 9050578A JP 9050578 A JP9050578 A JP 9050578A JP S5519209 A JPS5519209 A JP S5519209A
Authority
JP
Japan
Prior art keywords
formula
isoxazoline
spiro
compound
adamantane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9050578A
Other languages
Japanese (ja)
Inventor
Tadashi Sasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Grelan Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grelan Pharmaceutical Co Ltd filed Critical Grelan Pharmaceutical Co Ltd
Priority to JP9050578A priority Critical patent/JPS5519209A/en
Publication of JPS5519209A publication Critical patent/JPS5519209A/en
Pending legal-status Critical Current

Links

Landscapes

  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A derivative of adamantane-2-spiro-5'-Δ2'-isoxazoline of formula I (R=H, nitrile, alkoxycarbonyl; Ar=phenyl, substituted phenyl).
EXAMPLE: Anamantane-2-spiro-5'-3'-(2-nitrophenyl)-Δ2'-isoxazoline.
USE: Pharmaceuticals for the central nervous system and their intermediate, having an inhibitory activity of monoaminoxidase and an antiviral activity.
PROCESS: The reaction of a hydroxamic acid chloride with a base in an anhydrous medium forms a nitrile oxide of formula II. The compound is dried after removing the HC1 salt with water. Then a methyl adamantane of formula III is added and subjected to the 1,3-dipole addition reaction at room temp. for 1-48 hr, preferably ≤24 hr, to give the obtjective compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP9050578A 1978-07-26 1978-07-26 Adamantane derivative and its preparation Pending JPS5519209A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9050578A JPS5519209A (en) 1978-07-26 1978-07-26 Adamantane derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9050578A JPS5519209A (en) 1978-07-26 1978-07-26 Adamantane derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5519209A true JPS5519209A (en) 1980-02-09

Family

ID=14000348

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9050578A Pending JPS5519209A (en) 1978-07-26 1978-07-26 Adamantane derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5519209A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5730096A (en) * 1980-07-30 1982-02-18 Mitsubishi Electric Corp Continuity testing device for fire sensor channel
US10566049B2 (en) 2017-09-14 2020-02-18 Toshiba Memory Corporation Semiconductor memory device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5730096A (en) * 1980-07-30 1982-02-18 Mitsubishi Electric Corp Continuity testing device for fire sensor channel
US10566049B2 (en) 2017-09-14 2020-02-18 Toshiba Memory Corporation Semiconductor memory device

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