JPS5519209A - Adamantane derivative and its preparation - Google Patents
Adamantane derivative and its preparationInfo
- Publication number
- JPS5519209A JPS5519209A JP9050578A JP9050578A JPS5519209A JP S5519209 A JPS5519209 A JP S5519209A JP 9050578 A JP9050578 A JP 9050578A JP 9050578 A JP9050578 A JP 9050578A JP S5519209 A JPS5519209 A JP S5519209A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- isoxazoline
- spiro
- compound
- adamantane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A derivative of adamantane-2-spiro-5'-Δ2'-isoxazoline of formula I (R=H, nitrile, alkoxycarbonyl; Ar=phenyl, substituted phenyl).
EXAMPLE: Anamantane-2-spiro-5'-3'-(2-nitrophenyl)-Δ2'-isoxazoline.
USE: Pharmaceuticals for the central nervous system and their intermediate, having an inhibitory activity of monoaminoxidase and an antiviral activity.
PROCESS: The reaction of a hydroxamic acid chloride with a base in an anhydrous medium forms a nitrile oxide of formula II. The compound is dried after removing the HC1 salt with water. Then a methyl adamantane of formula III is added and subjected to the 1,3-dipole addition reaction at room temp. for 1-48 hr, preferably ≤24 hr, to give the obtjective compound of formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9050578A JPS5519209A (en) | 1978-07-26 | 1978-07-26 | Adamantane derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9050578A JPS5519209A (en) | 1978-07-26 | 1978-07-26 | Adamantane derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5519209A true JPS5519209A (en) | 1980-02-09 |
Family
ID=14000348
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9050578A Pending JPS5519209A (en) | 1978-07-26 | 1978-07-26 | Adamantane derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5519209A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5730096A (en) * | 1980-07-30 | 1982-02-18 | Mitsubishi Electric Corp | Continuity testing device for fire sensor channel |
US10566049B2 (en) | 2017-09-14 | 2020-02-18 | Toshiba Memory Corporation | Semiconductor memory device |
-
1978
- 1978-07-26 JP JP9050578A patent/JPS5519209A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5730096A (en) * | 1980-07-30 | 1982-02-18 | Mitsubishi Electric Corp | Continuity testing device for fire sensor channel |
US10566049B2 (en) | 2017-09-14 | 2020-02-18 | Toshiba Memory Corporation | Semiconductor memory device |
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