JPS55153592A - Preparation of plasminogen - Google Patents

Preparation of plasminogen

Info

Publication number
JPS55153592A
JPS55153592A JP6072979A JP6072979A JPS55153592A JP S55153592 A JPS55153592 A JP S55153592A JP 6072979 A JP6072979 A JP 6072979A JP 6072979 A JP6072979 A JP 6072979A JP S55153592 A JPS55153592 A JP S55153592A
Authority
JP
Japan
Prior art keywords
plasmin
inhibitor
plasminogen
natural
aqueous solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6072979A
Other languages
Japanese (ja)
Other versions
JPH0113837B2 (en
Inventor
Mitsuomi Oogaki
Ryozo Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Priority to JP6072979A priority Critical patent/JPS55153592A/en
Publication of JPS55153592A publication Critical patent/JPS55153592A/en
Publication of JPH0113837B2 publication Critical patent/JPH0113837B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PURPOSE: To remove plasmin economically and efficiently through adsorption, by bringing an aqueous solution of plasminogen containing plasmin into contact with a fixed natural plasmin inhibitor so that plasmin is selectively adsorbed.
CONSTITUTION: An aqueous solution of plasminogen containing plasmin is brought into contact with a fixed natural plasmin inhibitor to remove an existing plasmin through adsorption. A plasmin inhibitor selected from natural protease inhibitors, e.g., soybean trypsin inhibitor, an inhibitor of α1-globulin derived from the blood, a human urinous inhibitor, is used as the natural plasminogen inhibitor. A fixation carrier to bond the above-mentioned inhibitor chemically and to make it into an unsolved substance is, for example, a water-insoluble organic acid or an inorganic high polymen material having a carboxyl group, etc. In the contact of a raw material plasminogen aqueous solution with an adsorbent, pH is preferably 4W11.
COPYRIGHT: (C)1980,JPO&Japio
JP6072979A 1979-05-17 1979-05-17 Preparation of plasminogen Granted JPS55153592A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6072979A JPS55153592A (en) 1979-05-17 1979-05-17 Preparation of plasminogen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6072979A JPS55153592A (en) 1979-05-17 1979-05-17 Preparation of plasminogen

Publications (2)

Publication Number Publication Date
JPS55153592A true JPS55153592A (en) 1980-11-29
JPH0113837B2 JPH0113837B2 (en) 1989-03-08

Family

ID=13150652

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6072979A Granted JPS55153592A (en) 1979-05-17 1979-05-17 Preparation of plasminogen

Country Status (1)

Country Link
JP (1) JPS55153592A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52151711A (en) * 1976-04-07 1977-12-16 Choay Sa Aqueous composition with plasminogen activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52151711A (en) * 1976-04-07 1977-12-16 Choay Sa Aqueous composition with plasminogen activity

Also Published As

Publication number Publication date
JPH0113837B2 (en) 1989-03-08

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