JPS55149208A - Stabilization of biologically active substances with solid acid and base - Google Patents

Stabilization of biologically active substances with solid acid and base

Info

Publication number
JPS55149208A
JPS55149208A JP5752779A JP5752779A JPS55149208A JP S55149208 A JPS55149208 A JP S55149208A JP 5752779 A JP5752779 A JP 5752779A JP 5752779 A JP5752779 A JP 5752779A JP S55149208 A JPS55149208 A JP S55149208A
Authority
JP
Japan
Prior art keywords
base
active substance
biologically active
solid
solid acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5752779A
Other languages
Japanese (ja)
Other versions
JPS5727087B2 (en
Inventor
Hidehiko Takahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
YAKURIGAKU CHUO KENKYUSHO KK
Original Assignee
YAKURIGAKU CHUO KENKYUSHO KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by YAKURIGAKU CHUO KENKYUSHO KK filed Critical YAKURIGAKU CHUO KENKYUSHO KK
Priority to JP5752779A priority Critical patent/JPS55149208A/en
Publication of JPS55149208A publication Critical patent/JPS55149208A/en
Publication of JPS5727087B2 publication Critical patent/JPS5727087B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: A solid acid or solid base is added to a biologically active substance unstable in liquid state to prevent the denaturation caused by decomposition, polymerization and others, thus increasing the stability.
CONSTITUTION: To a biologically active substance which is unstable in the liq. state is added a solid acid of +6.8W-8.2 Ho such as silica-alumina catalyst, or solid base of 7.1W26.5 Ho such as CaO or ZnO according to H. A. Benesi (1956), thus said active substance is stabilized without changing the pH to behave as an acid or a base, when the mixture is used as a preparation such as aqueous solution, colloid, cream, ointment or cataplasma. However, appropriate selection of solid acids and bases is required so that the optimum weight ratio to the active substance is made small and the zone of effective amount ratio is kept wide.
COPYRIGHT: (C)1980,JPO&Japio
JP5752779A 1979-05-10 1979-05-10 Stabilization of biologically active substances with solid acid and base Granted JPS55149208A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5752779A JPS55149208A (en) 1979-05-10 1979-05-10 Stabilization of biologically active substances with solid acid and base

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5752779A JPS55149208A (en) 1979-05-10 1979-05-10 Stabilization of biologically active substances with solid acid and base

Publications (2)

Publication Number Publication Date
JPS55149208A true JPS55149208A (en) 1980-11-20
JPS5727087B2 JPS5727087B2 (en) 1982-06-08

Family

ID=13058210

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5752779A Granted JPS55149208A (en) 1979-05-10 1979-05-10 Stabilization of biologically active substances with solid acid and base

Country Status (1)

Country Link
JP (1) JPS55149208A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58201726A (en) * 1982-05-18 1983-11-24 Meiji Seika Kaisha Ltd Preparation of stable pharmaceutical
US4931274A (en) * 1986-02-27 1990-06-05 Physiological Research Associates Composition for the effective treatment of scalp diseases that delivers magnesium adsorbed in alumina silicate clays to affected sites

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59112140A (en) * 1982-12-17 1984-06-28 Tokyo Electric Power Co Inc:The Window to lessen consumed amount of energy for air conditioning and application thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58201726A (en) * 1982-05-18 1983-11-24 Meiji Seika Kaisha Ltd Preparation of stable pharmaceutical
JPH0233012B2 (en) * 1982-05-18 1990-07-25 Meiji Seika Co
US4931274A (en) * 1986-02-27 1990-06-05 Physiological Research Associates Composition for the effective treatment of scalp diseases that delivers magnesium adsorbed in alumina silicate clays to affected sites

Also Published As

Publication number Publication date
JPS5727087B2 (en) 1982-06-08

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