JPS55135590A - Modified asparaginase and uricase and their preparation - Google Patents
Modified asparaginase and uricase and their preparationInfo
- Publication number
- JPS55135590A JPS55135590A JP4120379A JP4120379A JPS55135590A JP S55135590 A JPS55135590 A JP S55135590A JP 4120379 A JP4120379 A JP 4120379A JP 4120379 A JP4120379 A JP 4120379A JP S55135590 A JPS55135590 A JP S55135590A
- Authority
- JP
- Japan
- Prior art keywords
- uricase
- asparaginase
- polyethylene glycol
- high polymer
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010092464 Urate Oxidase Proteins 0.000 title abstract 4
- DCXYFEDJOCDNAF-UHFFFAOYSA-M asparaginate Chemical class [O-]C(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-M 0.000 title abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 3
- 229920001223 polyethylene glycol Polymers 0.000 abstract 3
- 229920000642 polymer Polymers 0.000 abstract 3
- 102100025573 1-alkyl-2-acetylglycerophosphocholine esterase Human genes 0.000 abstract 2
- 108010024976 Asparaginase Proteins 0.000 abstract 2
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 239000004372 Polyvinyl alcohol Substances 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 abstract 1
- 229920002451 polyvinyl alcohol Polymers 0.000 abstract 1
- 229940068984 polyvinyl alcohol Drugs 0.000 abstract 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
Landscapes
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4120379A JPS55135590A (en) | 1979-04-05 | 1979-04-05 | Modified asparaginase and uricase and their preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4120379A JPS55135590A (en) | 1979-04-05 | 1979-04-05 | Modified asparaginase and uricase and their preparation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61093855A Division JPS6255079A (ja) | 1986-04-23 | 1986-04-23 | 修飾ウリカ−ゼ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55135590A true JPS55135590A (en) | 1980-10-22 |
| JPS6142558B2 JPS6142558B2 (enrdf_load_stackoverflow) | 1986-09-22 |
Family
ID=12601850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4120379A Granted JPS55135590A (en) | 1979-04-05 | 1979-04-05 | Modified asparaginase and uricase and their preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS55135590A (enrdf_load_stackoverflow) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4460683A (en) * | 1981-07-07 | 1984-07-17 | Boehringer Mannheim Gmbh | Soluble liver uricase with a process for the preparation thereof and with the use thereof |
| JPS62175175A (ja) * | 1986-01-28 | 1987-07-31 | Mihama Hisaharu | 修飾トリプトフアナ−ゼ及びその製法 |
| JP2002522399A (ja) * | 1998-08-06 | 2002-07-23 | マウンテン ビュー ファーマシューティカルズ，インコーポレイテッド | Ｐｅｇ−尿酸酸化酵素結合体およびその使用 |
| US7723089B2 (en) | 1998-08-06 | 2010-05-25 | Mountain View Pharmaceuticals, Inc. | PEG-urate oxidase conjugates and use thereof |
| US7927852B2 (en) | 1998-08-06 | 2011-04-19 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| US9534013B2 (en) | 2006-04-12 | 2017-01-03 | Horizon Pharma Rheumatology Llc | Purification of proteins with cationic surfactant |
| US9926537B2 (en) | 2005-04-11 | 2018-03-27 | Horizon Pharma Rheumatology Llc | Variant forms of urate oxidase and use thereof |
| US10139399B2 (en) | 2009-06-25 | 2018-11-27 | Horizon Pharma Rheumatology Llc | Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during PEGylated uricase therapy |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5515224B2 (ja) | 2007-02-28 | 2014-06-11 | 日油株式会社 | 多分岐鎖ポリオキシアルキレン誘導体 |
-
1979
- 1979-04-05 JP JP4120379A patent/JPS55135590A/ja active Granted
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4460683A (en) * | 1981-07-07 | 1984-07-17 | Boehringer Mannheim Gmbh | Soluble liver uricase with a process for the preparation thereof and with the use thereof |
| JPS62175175A (ja) * | 1986-01-28 | 1987-07-31 | Mihama Hisaharu | 修飾トリプトフアナ−ゼ及びその製法 |
| US9885024B2 (en) | 1998-08-06 | 2018-02-06 | Duke University | PEG-urate oxidase conjugates and use thereof |
| JP2002522399A (ja) * | 1998-08-06 | 2002-07-23 | マウンテン ビュー ファーマシューティカルズ，インコーポレイテッド | Ｐｅｇ−尿酸酸化酵素結合体およびその使用 |
| US7927852B2 (en) | 1998-08-06 | 2011-04-19 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| US7927589B2 (en) | 1998-08-06 | 2011-04-19 | Mountain View Pharmaceuticals, Inc. | PEG-urate oxidase conjugates and use thereof |
| US8067553B2 (en) | 1998-08-06 | 2011-11-29 | Mountain View Pharmaceuticals, Inc. | PEG-urate oxidase conjugates and use thereof |
| US8618267B2 (en) | 1998-08-06 | 2013-12-31 | Mountain View Pharmaceuticals, Inc. | PEG-urate oxidase conjugates and use thereof |
| US8921064B2 (en) | 1998-08-06 | 2014-12-30 | Mountain View Pharmaceuticals, Inc. | Method for purifying urate oxidase tetramers and octamers |
| US7723089B2 (en) | 1998-08-06 | 2010-05-25 | Mountain View Pharmaceuticals, Inc. | PEG-urate oxidase conjugates and use thereof |
| US9926538B2 (en) | 2005-04-11 | 2018-03-27 | Horizon Pharma Rheumatology Llc | Variant forms of urate oxidase and use thereof |
| US9926537B2 (en) | 2005-04-11 | 2018-03-27 | Horizon Pharma Rheumatology Llc | Variant forms of urate oxidase and use thereof |
| US11345899B2 (en) | 2005-04-11 | 2022-05-31 | Horizon Therapeutics Usa, Inc. | Variant forms of urate oxidase and use thereof |
| US10160958B2 (en) | 2005-04-11 | 2018-12-25 | Horizon Pharma Rheumatology Llc | Variant forms of urate oxidase and use thereof |
| US10731139B2 (en) | 2005-04-11 | 2020-08-04 | Horizon Pharma Rheumatology Llc | Variant forms of urate oxidase and use thereof |
| US11781119B2 (en) | 2005-04-11 | 2023-10-10 | Horizon Therapeutics Usa, Inc. | Variant forms of urate oxidase and use thereof |
| US9534013B2 (en) | 2006-04-12 | 2017-01-03 | Horizon Pharma Rheumatology Llc | Purification of proteins with cationic surfactant |
| US10139399B2 (en) | 2009-06-25 | 2018-11-27 | Horizon Pharma Rheumatology Llc | Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during PEGylated uricase therapy |
| US11598767B2 (en) | 2009-06-25 | 2023-03-07 | Horizon Therapeutics Usa, Inc. | Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy |
| US11639927B2 (en) | 2009-06-25 | 2023-05-02 | Horizon Therapeutics Usa, Inc. | Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during PEGylated uricase therapy |
| US10823727B2 (en) | 2009-06-25 | 2020-11-03 | Horizon Pharma Rheumatology Llc | Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy |
| US11982670B2 (en) | 2009-06-25 | 2024-05-14 | Horizon Therapeutics Usa, Inc. | Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy |
| US12188927B2 (en) | 2009-06-25 | 2025-01-07 | Horizon Therapeutics Usa, Inc. | Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during PEGylated uricase therapy |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6142558B2 (enrdf_load_stackoverflow) | 1986-09-22 |
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