JPS55118420A - Preparation of improved vaccine for hooping cough - Google Patents

Preparation of improved vaccine for hooping cough

Info

Publication number
JPS55118420A
JPS55118420A JP2655079A JP2655079A JPS55118420A JP S55118420 A JPS55118420 A JP S55118420A JP 2655079 A JP2655079 A JP 2655079A JP 2655079 A JP2655079 A JP 2655079A JP S55118420 A JPS55118420 A JP S55118420A
Authority
JP
Japan
Prior art keywords
vaccine
tannin
treated
hydrogen peroxide
purified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2655079A
Other languages
Japanese (ja)
Other versions
JPS6140210B2 (en
Inventor
Takashi Okonogi
Zenhachiro Hattori
Akira Ogiso
Takeshi Iida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHIBAKEN
Chiba Prefectural Government
Sankyo Co Ltd
Original Assignee
CHIBAKEN
Chiba Prefectural Government
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHIBAKEN, Chiba Prefectural Government, Sankyo Co Ltd filed Critical CHIBAKEN
Priority to JP2655079A priority Critical patent/JPS55118420A/en
Publication of JPS55118420A publication Critical patent/JPS55118420A/en
Publication of JPS6140210B2 publication Critical patent/JPS6140210B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

PURPOSE: The vaccine for hooping cough is treated with purified tannin from persimmon and then with hydrogen peroxide to remove or inactivate the toxic ingredients participating in the side-effects.
CONSTITUTION: A dispersion of dead cells of Homophilus pertussis in the physiological salt solution and a purified tannin from persimmon or condensed tannin therefrom are mixed to form a precipitate of light-brown cells. The precipitated cells are dispersed in the physiological salt solution or a phosphate buffer solution adjusted to about 7 pH and treated with hydrogen peroxide to give title vaccine. The concentration of hydrogen peroxide is preferably 3W10%. This treatment inhibits or inactivates lymphocytosis accelerating factor and histamine sensitizing factor without any adverse effect on immunogen. The resulting vaccine is better than conventional vaccine and vaccine treated with purified-tannin in irritating properties.
COPYRIGHT: (C)1980,JPO&Japio
JP2655079A 1979-03-07 1979-03-07 Preparation of improved vaccine for hooping cough Granted JPS55118420A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2655079A JPS55118420A (en) 1979-03-07 1979-03-07 Preparation of improved vaccine for hooping cough

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2655079A JPS55118420A (en) 1979-03-07 1979-03-07 Preparation of improved vaccine for hooping cough

Publications (2)

Publication Number Publication Date
JPS55118420A true JPS55118420A (en) 1980-09-11
JPS6140210B2 JPS6140210B2 (en) 1986-09-08

Family

ID=12196618

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2655079A Granted JPS55118420A (en) 1979-03-07 1979-03-07 Preparation of improved vaccine for hooping cough

Country Status (1)

Country Link
JP (1) JPS55118420A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0269729A1 (en) * 1986-06-16 1988-06-08 Ronald D Sekura Method of preparing toxoid.
WO2008039171A2 (en) * 2005-08-08 2008-04-03 Oregon Health & Science University Inactivating pathogens with hydrogen peroxide for vaccine production
CN104524154A (en) * 2014-12-29 2015-04-22 河南天纳图生物科技有限公司 Compound fermented traditional Chinese medicine for relieving cough and asthma of livestock and poultry and preparation method of compound fermented traditional Chinese medicine

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0269729A1 (en) * 1986-06-16 1988-06-08 Ronald D Sekura Method of preparing toxoid.
WO2008039171A2 (en) * 2005-08-08 2008-04-03 Oregon Health & Science University Inactivating pathogens with hydrogen peroxide for vaccine production
WO2008039171A3 (en) * 2005-08-08 2008-06-12 Univ Oregon Health & Science Inactivating pathogens with hydrogen peroxide for vaccine production
US8124397B2 (en) 2005-08-08 2012-02-28 Oregon Health & Science University Inactivating pathogens with oxidizing agents for vaccine production
US8716000B2 (en) 2005-08-08 2014-05-06 Oregon Health And Science University Inactivating pathogens with oxidizing agents for vaccine production
US10143740B2 (en) 2005-08-08 2018-12-04 Oregon Health And Science University Inactivating pathogens with oxidizing agents for vaccine production
CN104524154A (en) * 2014-12-29 2015-04-22 河南天纳图生物科技有限公司 Compound fermented traditional Chinese medicine for relieving cough and asthma of livestock and poultry and preparation method of compound fermented traditional Chinese medicine

Also Published As

Publication number Publication date
JPS6140210B2 (en) 1986-09-08

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