JPS55113751A - 2-oxo-3-(4-aminophenyl)butaneamide and its preparation - Google Patents

2-oxo-3-(4-aminophenyl)butaneamide and its preparation

Info

Publication number
JPS55113751A
JPS55113751A JP2136179A JP2136179A JPS55113751A JP S55113751 A JPS55113751 A JP S55113751A JP 2136179 A JP2136179 A JP 2136179A JP 2136179 A JP2136179 A JP 2136179A JP S55113751 A JPS55113751 A JP S55113751A
Authority
JP
Japan
Prior art keywords
acid
butaneamide
aminophenyl
oxo
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2136179A
Other languages
Japanese (ja)
Inventor
Kazuo Kikazawa
Mineji Hiiragi
Haruhide Ishimaru
Toshihisa Nakamura
Keiko Shiroyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Grelan Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grelan Pharmaceutical Co Ltd filed Critical Grelan Pharmaceutical Co Ltd
Priority to JP2136179A priority Critical patent/JPS55113751A/en
Publication of JPS55113751A publication Critical patent/JPS55113751A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:2-Oxo-3-(4-aminophenyl)butaneamide.
USE: An anti-inflammatory anodyme. Useful as a preparative intermediate for 2- oxophenylbutaneamide.
PROCESS: A compound shown by the formula II [R is amino-protective group, (e.g., benzoyl, acetyl, formyl, phthaloyl, etc.)] is hydrolyzed in the presence of an acid (e.g., inorganic acid such as hydrochloric acid or hydrobromic acid) or a base (e.g., alkali metal) in a solvent, e.g., water, methanol under such a mild condition as to be heated slightly to remove the amino-protective group so that a compound shown by the formula I is obtained. The compound can also be prepared by other separation methods through chemical or catalytic reduction.
COPYRIGHT: (C)1980,JPO&Japio
JP2136179A 1979-02-27 1979-02-27 2-oxo-3-(4-aminophenyl)butaneamide and its preparation Pending JPS55113751A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2136179A JPS55113751A (en) 1979-02-27 1979-02-27 2-oxo-3-(4-aminophenyl)butaneamide and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2136179A JPS55113751A (en) 1979-02-27 1979-02-27 2-oxo-3-(4-aminophenyl)butaneamide and its preparation

Publications (1)

Publication Number Publication Date
JPS55113751A true JPS55113751A (en) 1980-09-02

Family

ID=12052949

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2136179A Pending JPS55113751A (en) 1979-02-27 1979-02-27 2-oxo-3-(4-aminophenyl)butaneamide and its preparation

Country Status (1)

Country Link
JP (1) JPS55113751A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4939133A (en) * 1985-10-01 1990-07-03 Warner-Lambert Company N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4939133A (en) * 1985-10-01 1990-07-03 Warner-Lambert Company N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade

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