JPS5441883A - Thiamine derivative and its preparation - Google Patents
Thiamine derivative and its preparationInfo
- Publication number
- JPS5441883A JPS5441883A JP10694377A JP10694377A JPS5441883A JP S5441883 A JPS5441883 A JP S5441883A JP 10694377 A JP10694377 A JP 10694377A JP 10694377 A JP10694377 A JP 10694377A JP S5441883 A JPS5441883 A JP S5441883A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- preparation
- formulai
- alkali metal
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:Thiamine derivatives of formulaI(R is H, lower alkyl, aralkyl) and their salts. EXAMPLE:3-[2-N-(4-amino-2-methyl-5-pyrimidnyl)methylformamide-1-(2-hyd roxyethyl)-1-propenyldithio]-2-methylpropionyl-L-proline benzyl ester. USE:It has vitamin B1 activity as well as activities inhibiting the enzyme transforming angiotensin and the enzyme hydrolyzing bradykinin (kininase) and is used as preventive agents or remedy for hyperpiesia. PREPARATION:A compound of formula II is reacted with a compound of formula III[either X or Y is MSO3-(M is alkali metal) and the other is H or alkali metal] to form the compound of formulaI.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10694377A JPS5441883A (en) | 1977-09-05 | 1977-09-05 | Thiamine derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10694377A JPS5441883A (en) | 1977-09-05 | 1977-09-05 | Thiamine derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5441883A true JPS5441883A (en) | 1979-04-03 |
JPS6154798B2 JPS6154798B2 (en) | 1986-11-25 |
Family
ID=14446449
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10694377A Granted JPS5441883A (en) | 1977-09-05 | 1977-09-05 | Thiamine derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5441883A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005072738A1 (en) * | 2004-01-30 | 2005-08-11 | Faron Pharmaceuticals Oy | Compositions useful especially for treatment or prevention of metabolic syndrome |
-
1977
- 1977-09-05 JP JP10694377A patent/JPS5441883A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005072738A1 (en) * | 2004-01-30 | 2005-08-11 | Faron Pharmaceuticals Oy | Compositions useful especially for treatment or prevention of metabolic syndrome |
Also Published As
Publication number | Publication date |
---|---|
JPS6154798B2 (en) | 1986-11-25 |
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