JPS54154714A - Nitrosourea derivative and its preparation - Google Patents

Nitrosourea derivative and its preparation

Info

Publication number
JPS54154714A
JPS54154714A JP6345978A JP6345978A JPS54154714A JP S54154714 A JPS54154714 A JP S54154714A JP 6345978 A JP6345978 A JP 6345978A JP 6345978 A JP6345978 A JP 6345978A JP S54154714 A JPS54154714 A JP S54154714A
Authority
JP
Japan
Prior art keywords
formula
preparation
aldohexopyranose
nitrosation
nitrosourea derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6345978A
Other languages
Japanese (ja)
Other versions
JPS5919555B2 (en
Inventor
Kenji Tsujihara
Masakatsu Ozeki
Yoshihisa Arai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP6345978A priority Critical patent/JPS5919555B2/en
Priority to US05/922,811 priority patent/US4182757A/en
Priority to FI782215A priority patent/FI65439C/en
Priority to MX10099078U priority patent/MX5407E/en
Priority to DE2858078A priority patent/DE2858078C2/en
Priority to DE2832127A priority patent/DE2832127C2/en
Priority to DE19782857911 priority patent/DE2857911C2/en
Priority to CA307,987A priority patent/CA1097624A/en
Priority to PH21418A priority patent/PH13936A/en
Priority to DK331978A priority patent/DK331978A/en
Priority to SE7808162A priority patent/SE435501B/en
Priority to HU78TA1491A priority patent/HU176891B/en
Priority to CH809678A priority patent/CH636626A5/en
Priority to AT546178A priority patent/AT360553B/en
Priority to IT68797/78A priority patent/IT1160450B/en
Priority to NL7808036A priority patent/NL7808036A/en
Priority to PL1978208701A priority patent/PL111784B1/en
Priority to BE189567A priority patent/BE869352A/en
Priority to PT68359A priority patent/PT68359A/en
Priority to FR7822477A priority patent/FR2403994A1/en
Priority to AR273129A priority patent/AR219331A1/en
Priority to SU782643999A priority patent/SU908247A3/en
Priority to EG46478A priority patent/EG13375A/en
Priority to CS785045A priority patent/CS216918B2/en
Priority to GB8027528A priority patent/GB2053918B/en
Priority to AU38491/78A priority patent/AU525239B2/en
Priority to GB7831712A priority patent/GB2002370B/en
Publication of JPS54154714A publication Critical patent/JPS54154714A/en
Priority to FR8105772A priority patent/FR2475040B1/fr
Priority to FR8115054A priority patent/FR2485541B1/fr
Priority to FR8205133A priority patent/FR2499577A1/en
Publication of JPS5919555B2 publication Critical patent/JPS5919555B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Nitrosourea derivatives of formula I (R1 is aldopentropyranose, aldohexopyranose or 4-0-aldohexopyranosyl-aldohexopyranose residue in which the hemiacetal hydroxyl group in the 1-position is removed; R2 is 3W6C alkenyl or alkynyl that may branch).
EXAMPLE: 1-(2-Chloroethyl)-1-nitroso-allyl-3-L-arabinopyranosylurea.
USE: Antitumorigenic agents, being extremely low in toxicity.
PREPARATION: The nitrosation of a urea derivative of formula II gives the compound of formula I. The nitrosation agent used is preferably, e.g., N2O4, NO3 or nitrous acid.
COPYRIGHT: (C)1979,JPO&Japio
JP6345978A 1977-07-29 1978-05-26 Nitrosourea transparent conductor and its manufacturing method Expired JPS5919555B2 (en)

Priority Applications (30)

Application Number Priority Date Filing Date Title
JP6345978A JPS5919555B2 (en) 1978-05-26 1978-05-26 Nitrosourea transparent conductor and its manufacturing method
US05/922,811 US4182757A (en) 1977-07-29 1978-07-10 Novel nitrosourea compounds and process for preparing the same
FI782215A FI65439C (en) 1977-07-29 1978-07-11 REFERENCE TO A NUTROSOURE DEFINITION WITH ANTI-TURMOERACTIVITY
MX10099078U MX5407E (en) 1977-07-29 1978-07-20 PROCEDURE FOR PREPARING NITROSOUREA COMPOUNDS
DE2858078A DE2858078C2 (en) 1977-07-29 1978-07-21 2-chloroethylnitrosoureas, processes for their preparation and pharmaceutical preparations containing these compounds
DE2832127A DE2832127C2 (en) 1977-07-29 1978-07-21 1- (2-chloroethyl) -1-nitroso-3-substituted-3-glycosylureas, processes for their preparation and pharmaceutical preparations containing these compounds
DE19782857911 DE2857911C2 (en) 1977-07-29 1978-07-21 1- (2-chloroethyl) -3-substituted-3-glycosylureas, processes for their production and their use for the production of 1- (2-chloroethyl) -1-nitroso-3-substituted-3-glycosylureas
CA307,987A CA1097624A (en) 1977-07-29 1978-07-24 Nitrosourea compounds and process for preparing the same
PH21418A PH13936A (en) 1977-07-29 1978-07-25 Novel nitrosourea compounds and process for preparing the same
DK331978A DK331978A (en) 1977-07-29 1978-07-26 NITROSOURIN INDUSTRIAL DERIVATIVES AND PROCEDURES FOR THE PREPARATION
SE7808162A SE435501B (en) 1977-07-29 1978-07-26 NITROSOCARBAMIDE DERIVATIVES AND PHARMACOLOGICAL COMPOSITION CONTAINING THIS
HU78TA1491A HU176891B (en) 1977-07-29 1978-07-27 Process for preparing nitroso-carbamide derivatives
CH809678A CH636626A5 (en) 1977-07-29 1978-07-27 NITROSO-UREA COMPOUNDS AND METHOD FOR THE PRODUCTION AND USE THEREOF IN THERAPEUTIC AGENTS.
AT546178A AT360553B (en) 1977-07-29 1978-07-27 METHOD FOR PRODUCING NEW NITROSOURATE COMPOUNDS
IT68797/78A IT1160450B (en) 1977-07-29 1978-07-27 NITROSUREIC COMPOUNDS AND PROCEDURE FOR THEIR PREPARATION
NL7808036A NL7808036A (en) 1977-07-29 1978-07-28 NITROSOUREUM DERIVATIVES.
PL1978208701A PL111784B1 (en) 1977-07-29 1978-07-28 Method of manufacture of novel derivatives of nitrosourea
BE189567A BE869352A (en) 1977-07-29 1978-07-28 NEW NITROSOUREES AND THEIR APPLICATION
PT68359A PT68359A (en) 1977-07-29 1978-07-28 Process for preparing novel nitrosourea derivatives
FR7822477A FR2403994A1 (en) 1977-07-29 1978-07-28 NEWS 1- (2-CHLOROETHYL) -1-NITROSOUREES USEFUL IN PARTICULAR AS ANTITUMOR AGENTS AND THEIR PREPARATION PROCESS
AR273129A AR219331A1 (en) 1977-07-29 1978-07-28 NEW DERIVATIVE FROM UREA, PARTICULARLY USEFUL AS A NON-PHARMACOLOGICAL INTERMEDIARY IN THE PRODUCTION OF A NITROSOUREA COMPOUND AND PROCEDURE FOR THE PREPARATION OF THE NITROSOUREA COMPOUND
SU782643999A SU908247A3 (en) 1977-07-29 1978-07-28 Process for preparing nitroso urea derivatives
EG46478A EG13375A (en) 1977-07-29 1978-07-29 Nitrosourea compounds and process for preparing the same
GB8027528A GB2053918B (en) 1977-07-29 1978-07-31 Urea compounds
CS785045A CS216918B2 (en) 1977-07-29 1978-07-31 Method of preparation of the nitrurea
AU38491/78A AU525239B2 (en) 1977-07-29 1978-07-31 Improvements in or relating to nitrosourea compounds
GB7831712A GB2002370B (en) 1977-07-29 1978-07-31 Nitrosourea compounds and process for preparing the same
FR8105772A FR2475040B1 (en) 1977-07-29 1981-03-23
FR8115054A FR2485541B1 (en) 1977-07-29 1981-08-03
FR8205133A FR2499577A1 (en) 1977-07-29 1982-03-25 SUBSTITUTED 1- (2-CHLOROETHYL) -1-NITROSOUREES-3-SUBSTITUTED BY SUGAR REST, PARTICULARLY USEFUL AS ANTITUMOR AGENTS AND PROCESS FOR THE PREPARATION THEREOF

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6345978A JPS5919555B2 (en) 1978-05-26 1978-05-26 Nitrosourea transparent conductor and its manufacturing method

Publications (2)

Publication Number Publication Date
JPS54154714A true JPS54154714A (en) 1979-12-06
JPS5919555B2 JPS5919555B2 (en) 1984-05-07

Family

ID=13229834

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6345978A Expired JPS5919555B2 (en) 1977-07-29 1978-05-26 Nitrosourea transparent conductor and its manufacturing method

Country Status (1)

Country Link
JP (1) JPS5919555B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009139181A1 (en) 2008-05-15 2009-11-19 大正製薬株式会社 10a-azalide compound having 4-membered ring structure

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0120301Y2 (en) * 1984-11-15 1989-06-15

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009139181A1 (en) 2008-05-15 2009-11-19 大正製薬株式会社 10a-azalide compound having 4-membered ring structure

Also Published As

Publication number Publication date
JPS5919555B2 (en) 1984-05-07

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