JPS54132586A - 5-fluorouracil derivative - Google Patents
5-fluorouracil derivativeInfo
- Publication number
- JPS54132586A JPS54132586A JP4087878A JP4087878A JPS54132586A JP S54132586 A JPS54132586 A JP S54132586A JP 4087878 A JP4087878 A JP 4087878A JP 4087878 A JP4087878 A JP 4087878A JP S54132586 A JPS54132586 A JP S54132586A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- fluorouracil
- solvent
- derivative
- fluorouracil derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:5-Fluorouracil derivative of formula I (R1,2 are H, lower alkoxy; provided that both R1 and R2 are not H at the same time; R1 and R2 may together from lower alkylene dioxy group).
EXAMPLE: 5-Fluoro-2-piperonyloxy-3H-pyrimidin-4-one.
USE: Low-toxic carcinostatic agent having stronger carcinostatic activity than 5- fluorouracil or its 2-benzyl derivative.
PROCESS: The compound I is prepared by heating a compound II (X is halogen) with a compound III (M is alkali metal) in a solvent such as toluene, THF, etc., at 60W140°C, pref. refluxing near the boiling point of the solvent.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53040878A JPS6050191B2 (en) | 1978-04-07 | 1978-04-07 | 5↓-Fluorouracil derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53040878A JPS6050191B2 (en) | 1978-04-07 | 1978-04-07 | 5↓-Fluorouracil derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54132586A true JPS54132586A (en) | 1979-10-15 |
JPS6050191B2 JPS6050191B2 (en) | 1985-11-07 |
Family
ID=12592760
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53040878A Expired JPS6050191B2 (en) | 1978-04-07 | 1978-04-07 | 5↓-Fluorouracil derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6050191B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6417192B1 (en) * | 1997-11-06 | 2002-07-09 | Smithkline Beecham P.L.C. | Pyrimidinone compounds and pharmaceutical compositions containing them |
-
1978
- 1978-04-07 JP JP53040878A patent/JPS6050191B2/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6417192B1 (en) * | 1997-11-06 | 2002-07-09 | Smithkline Beecham P.L.C. | Pyrimidinone compounds and pharmaceutical compositions containing them |
Also Published As
Publication number | Publication date |
---|---|
JPS6050191B2 (en) | 1985-11-07 |
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