JPS54110318A - Bleomycin solid preparation - Google Patents
Bleomycin solid preparationInfo
- Publication number
- JPS54110318A JPS54110318A JP1515878A JP1515878A JPS54110318A JP S54110318 A JPS54110318 A JP S54110318A JP 1515878 A JP1515878 A JP 1515878A JP 1515878 A JP1515878 A JP 1515878A JP S54110318 A JPS54110318 A JP S54110318A
- Authority
- JP
- Japan
- Prior art keywords
- bleomycin
- parts
- solid preparation
- beeswax
- fatty acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PURPOSE: To provide a slow-release bleomycin solid preparation which can be administered topically, and keeps effective local concentration for a long period without causing side effects such as inflammation at the normal tissues, composed of a carcinostatic agnet bleomycin, beeswax, a higher fatty acid triglyceride, and a polyoxyethylene derivative.
CONSTITUTION: A mixture comprising (A) bleomycin, (B) beeswax, (C) a higher fatty acid triglyceride, pref. a hydrogenated animal or vegetable oil or synthetic oils and fats having a softening point of 30W50°C, e.g. Witepsol E-85, and (D) a polyoxyethylene derivative having an HLB value of ≥ 7, e.g. polyoxyethylene sorbitan monooleate, is molten and filled in, e.g. a polyethylene tube. The mold is cooled and cut into proper lengths to obtain the desired bleomycin solid preparation. One tablet of the preparation (100 parts) contains pref. 3W100mg titer (about 1W50mg in weight) of (A), 1W50 parts of (B), 1W40 parts of (C) and the rest part of (C).
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53015158A JPS6052682B2 (en) | 1978-02-13 | 1978-02-13 | Bleomycin solid preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53015158A JPS6052682B2 (en) | 1978-02-13 | 1978-02-13 | Bleomycin solid preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54110318A true JPS54110318A (en) | 1979-08-29 |
JPS6052682B2 JPS6052682B2 (en) | 1985-11-20 |
Family
ID=11880983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53015158A Expired JPS6052682B2 (en) | 1978-02-13 | 1978-02-13 | Bleomycin solid preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6052682B2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05194223A (en) * | 1992-09-11 | 1993-08-03 | Kyorin Pharmaceut Co Ltd | Sustained release suppository composition for 3-isobutyryl-2-isopropylpyrazolo(1,5-a)pyridine |
JP2022504958A (en) * | 2018-10-19 | 2022-01-13 | ソシエテ・デクスプロワタシオン・デ・プロデュイ・プール・レ・アンデュストリー・シミック・セピック | A lipid composition for encapsulating the active substance, which allows control of the release rate of the active substance. |
-
1978
- 1978-02-13 JP JP53015158A patent/JPS6052682B2/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05194223A (en) * | 1992-09-11 | 1993-08-03 | Kyorin Pharmaceut Co Ltd | Sustained release suppository composition for 3-isobutyryl-2-isopropylpyrazolo(1,5-a)pyridine |
JP2022504958A (en) * | 2018-10-19 | 2022-01-13 | ソシエテ・デクスプロワタシオン・デ・プロデュイ・プール・レ・アンデュストリー・シミック・セピック | A lipid composition for encapsulating the active substance, which allows control of the release rate of the active substance. |
Also Published As
Publication number | Publication date |
---|---|
JPS6052682B2 (en) | 1985-11-20 |
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