JPS54110318A - Bleomycin solid preparation - Google Patents

Bleomycin solid preparation

Info

Publication number
JPS54110318A
JPS54110318A JP1515878A JP1515878A JPS54110318A JP S54110318 A JPS54110318 A JP S54110318A JP 1515878 A JP1515878 A JP 1515878A JP 1515878 A JP1515878 A JP 1515878A JP S54110318 A JPS54110318 A JP S54110318A
Authority
JP
Japan
Prior art keywords
bleomycin
parts
solid preparation
beeswax
fatty acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1515878A
Other languages
Japanese (ja)
Other versions
JPS6052682B2 (en
Inventor
Shigetoshi Shoji
Koichi Yoshida
Hiroshi Ninomiya
Takumi Yamashita
Yoshimasa Hashimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP53015158A priority Critical patent/JPS6052682B2/en
Publication of JPS54110318A publication Critical patent/JPS54110318A/en
Publication of JPS6052682B2 publication Critical patent/JPS6052682B2/en
Expired legal-status Critical Current

Links

Landscapes

  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PURPOSE: To provide a slow-release bleomycin solid preparation which can be administered topically, and keeps effective local concentration for a long period without causing side effects such as inflammation at the normal tissues, composed of a carcinostatic agnet bleomycin, beeswax, a higher fatty acid triglyceride, and a polyoxyethylene derivative.
CONSTITUTION: A mixture comprising (A) bleomycin, (B) beeswax, (C) a higher fatty acid triglyceride, pref. a hydrogenated animal or vegetable oil or synthetic oils and fats having a softening point of 30W50°C, e.g. Witepsol E-85, and (D) a polyoxyethylene derivative having an HLB value of ≥ 7, e.g. polyoxyethylene sorbitan monooleate, is molten and filled in, e.g. a polyethylene tube. The mold is cooled and cut into proper lengths to obtain the desired bleomycin solid preparation. One tablet of the preparation (100 parts) contains pref. 3W100mg titer (about 1W50mg in weight) of (A), 1W50 parts of (B), 1W40 parts of (C) and the rest part of (C).
COPYRIGHT: (C)1979,JPO&Japio
JP53015158A 1978-02-13 1978-02-13 Bleomycin solid preparation Expired JPS6052682B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP53015158A JPS6052682B2 (en) 1978-02-13 1978-02-13 Bleomycin solid preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53015158A JPS6052682B2 (en) 1978-02-13 1978-02-13 Bleomycin solid preparation

Publications (2)

Publication Number Publication Date
JPS54110318A true JPS54110318A (en) 1979-08-29
JPS6052682B2 JPS6052682B2 (en) 1985-11-20

Family

ID=11880983

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53015158A Expired JPS6052682B2 (en) 1978-02-13 1978-02-13 Bleomycin solid preparation

Country Status (1)

Country Link
JP (1) JPS6052682B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05194223A (en) * 1992-09-11 1993-08-03 Kyorin Pharmaceut Co Ltd Sustained release suppository composition for 3-isobutyryl-2-isopropylpyrazolo(1,5-a)pyridine
JP2022504958A (en) * 2018-10-19 2022-01-13 ソシエテ・デクスプロワタシオン・デ・プロデュイ・プール・レ・アンデュストリー・シミック・セピック A lipid composition for encapsulating the active substance, which allows control of the release rate of the active substance.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05194223A (en) * 1992-09-11 1993-08-03 Kyorin Pharmaceut Co Ltd Sustained release suppository composition for 3-isobutyryl-2-isopropylpyrazolo(1,5-a)pyridine
JP2022504958A (en) * 2018-10-19 2022-01-13 ソシエテ・デクスプロワタシオン・デ・プロデュイ・プール・レ・アンデュストリー・シミック・セピック A lipid composition for encapsulating the active substance, which allows control of the release rate of the active substance.

Also Published As

Publication number Publication date
JPS6052682B2 (en) 1985-11-20

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