JPS5331694A - 3-aminopyrazolo(3,4- )pyrimidine derivatives and their preparation - Google Patents
3-aminopyrazolo(3,4- )pyrimidine derivatives and their preparationInfo
- Publication number
- JPS5331694A JPS5331694A JP10519176A JP10519176A JPS5331694A JP S5331694 A JPS5331694 A JP S5331694A JP 10519176 A JP10519176 A JP 10519176A JP 10519176 A JP10519176 A JP 10519176A JP S5331694 A JPS5331694 A JP S5331694A
- Authority
- JP
- Japan
- Prior art keywords
- aminopyrazolo
- preparation
- pyrimidine derivatives
- pyrimidine
- acyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: 3-Aminopyrazolo [3,4-d] pyrimidine derivatives of formula I (R1 - R3 are H or alkyl; R3 is H, alkyl, aryl, aralkyl or acyl; R5 is H, acyl, alkylcarbamoyl or alkylthiocarbamoyl) and their salts, e.g. 3-methylamino-5,7-diethylpyrazolo [3,4-d] pyrimidine.
COPYRIGHT: (C)1978,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10519176A JPS6032638B2 (en) | 1976-09-01 | 1976-09-01 | 3-Aminopyrazolo[3,4-d]pyrimidine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10519176A JPS6032638B2 (en) | 1976-09-01 | 1976-09-01 | 3-Aminopyrazolo[3,4-d]pyrimidine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5331694A true JPS5331694A (en) | 1978-03-25 |
JPS6032638B2 JPS6032638B2 (en) | 1985-07-29 |
Family
ID=14400771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10519176A Expired JPS6032638B2 (en) | 1976-09-01 | 1976-09-01 | 3-Aminopyrazolo[3,4-d]pyrimidine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6032638B2 (en) |
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS615082A (en) * | 1984-06-18 | 1986-01-10 | Takeda Chem Ind Ltd | 3-aminopyrazolo(3,4-d)pyrimidine derivative |
US4912104A (en) * | 1987-08-31 | 1990-03-27 | Takeda Chemical Industries, Ltd. | Tricyclic fused pryimidine derivatives, and their use as pharmaceuticals |
EP2023729A2 (en) * | 2006-06-06 | 2009-02-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
JP2012510991A (en) * | 2008-12-06 | 2012-05-17 | イントラ−セルラー・セラピーズ・インコーポレイテッド | Organic compounds |
JP2012510996A (en) * | 2008-12-06 | 2012-05-17 | イントラ−セルラー・セラピーズ・インコーポレイテッド | Organic compounds |
JP2012510995A (en) * | 2008-12-06 | 2012-05-17 | イントラ−セルラー・セラピーズ・インコーポレイテッド | Organic compounds |
US8273750B2 (en) | 2005-06-06 | 2012-09-25 | Takeda Pharmaceutical Company Limited | Organic compounds |
US8846693B2 (en) | 2007-12-06 | 2014-09-30 | Intra-Cellular Therapies, Inc. | Optionally substituted pyrazolo[3,4-d]pyrimidine-4,6-diones |
US9006258B2 (en) | 2006-12-05 | 2015-04-14 | Intra-Cellular Therapies, Inc. | Method of treating female sexual dysfunction with a PDE1 inhibitor |
US9073936B2 (en) | 2013-03-15 | 2015-07-07 | Intra-Cellular Therapies, Inc. | Organic compounds |
US9157906B2 (en) | 2001-08-31 | 2015-10-13 | The Rockefeller University | Phosphodiesterase activity and regulation of phosphodiesterase 1B-mediated signaling in brain |
US9198924B2 (en) | 2006-11-13 | 2015-12-01 | Intra-Cellular Therapies, Inc. | Organic compounds |
US9371327B2 (en) | 2010-05-31 | 2016-06-21 | Intra-Cellular Therapies, Inc. | PDE1 inhibitor compounds |
US9434730B2 (en) | 2010-05-31 | 2016-09-06 | Intra-Cellular Therapies, Inc. | PDE1 inhibitor compounds |
US9468637B2 (en) | 2009-05-13 | 2016-10-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
US9545406B2 (en) | 2013-03-15 | 2017-01-17 | Intra-Cellular Therapies, Inc. | Method of treating a CNS injury with a PDE1 inhibitor |
US9546175B2 (en) | 2014-08-07 | 2017-01-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
US9556185B2 (en) | 2010-05-31 | 2017-01-31 | Intra-Cellular Therapies, Inc. | Organic compounds |
US9605041B2 (en) | 2009-08-05 | 2017-03-28 | Intra-Cellular Therapies, Inc. | Regulatory proteins and inhibitors |
US9763948B2 (en) | 2010-05-31 | 2017-09-19 | Intra-Cellular Therapies, Inc. | PDE1 inhibitory compounds and methods |
US9801882B2 (en) | 2013-02-17 | 2017-10-31 | Intra-Cellular Therapies, Inc. | Phosphodiesterase-1 inhibitors and their use in treatment of cardiovascular diseases |
US9884872B2 (en) | 2014-06-20 | 2018-02-06 | Intra-Cellular Therapies, Inc. | Organic compounds |
US10131671B2 (en) | 2014-08-07 | 2018-11-20 | Intra-Cellular Therapies, Inc. | Organic compounds |
US10150774B2 (en) | 2014-09-17 | 2018-12-11 | Intra-Cellular Therapies, Inc. | Compounds and methods |
US10285992B2 (en) | 2014-08-07 | 2019-05-14 | Intra-Cellular Therapies, Inc. | Combinations of PDE1 inhibitors and NEP inhibitors and associated methods |
US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
US11291666B2 (en) | 2016-09-12 | 2022-04-05 | Intra-Cellular Therapies, Inc. | Uses |
US11464781B2 (en) | 2009-02-25 | 2022-10-11 | Intra-Cellular Therapies, Inc. | PDE1 inhibitors for ophthalmic disorders |
US11759465B2 (en) | 2018-01-31 | 2023-09-19 | Intra-Cellular Therapies, Inc. | Uses |
-
1976
- 1976-09-01 JP JP10519176A patent/JPS6032638B2/en not_active Expired
Cited By (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0113712B2 (en) * | 1984-06-18 | 1989-03-07 | Takeda Chemical Industries Ltd | |
JPS615082A (en) * | 1984-06-18 | 1986-01-10 | Takeda Chem Ind Ltd | 3-aminopyrazolo(3,4-d)pyrimidine derivative |
US4912104A (en) * | 1987-08-31 | 1990-03-27 | Takeda Chemical Industries, Ltd. | Tricyclic fused pryimidine derivatives, and their use as pharmaceuticals |
US9157906B2 (en) | 2001-08-31 | 2015-10-13 | The Rockefeller University | Phosphodiesterase activity and regulation of phosphodiesterase 1B-mediated signaling in brain |
US8273750B2 (en) | 2005-06-06 | 2012-09-25 | Takeda Pharmaceutical Company Limited | Organic compounds |
US9000001B2 (en) | 2005-06-06 | 2015-04-07 | Intra-Cellular Therapies, Inc. | Organic compounds |
US9624230B2 (en) | 2005-06-06 | 2017-04-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
JP2009539872A (en) * | 2006-06-06 | 2009-11-19 | イントラ−セルラー・セラピーズ・インコーポレイテッド | Organic compounds |
US9255099B2 (en) | 2006-06-06 | 2016-02-09 | Intra-Cellular Therapies, Inc. | Pyrazolo[3,4-D]pyrimidine-4,6(5H,7H)-diones as phosphodiesterase 1 inhibitors |
AU2007256633B2 (en) * | 2006-06-06 | 2013-09-12 | Intra-Cellular Therapies, Inc. | Organic compounds |
JP2014012729A (en) * | 2006-06-06 | 2014-01-23 | Intra-Cellular Therapies Inc | Organic compounds |
EP2023729A4 (en) * | 2006-06-06 | 2010-07-14 | Intra Cellular Therapies Inc | Organic compounds |
EP2023729A2 (en) * | 2006-06-06 | 2009-02-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
US9198924B2 (en) | 2006-11-13 | 2015-12-01 | Intra-Cellular Therapies, Inc. | Organic compounds |
US9006258B2 (en) | 2006-12-05 | 2015-04-14 | Intra-Cellular Therapies, Inc. | Method of treating female sexual dysfunction with a PDE1 inhibitor |
US8846693B2 (en) | 2007-12-06 | 2014-09-30 | Intra-Cellular Therapies, Inc. | Optionally substituted pyrazolo[3,4-d]pyrimidine-4,6-diones |
US8697710B2 (en) | 2008-12-06 | 2014-04-15 | Intra-Cellular Therapies, Inc. | Optionally substituted 3-amino-4-(thioxo or imino)-4,5-dihydro-2H-pyrazolo [3,4-d]pyrimidin-6(7H)-ones |
US8927556B2 (en) | 2008-12-06 | 2015-01-06 | Intra-Cellular Therapies, Inc. | 1H-pyrrolo[3,4-D]pyrimidin-2(6H)-one compounds |
US8859564B2 (en) | 2008-12-06 | 2014-10-14 | Intra-Cellular Therapies, Inc. | Pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione derivatives useful as inhibitors of phosphodiesterase 1 |
JP2012510995A (en) * | 2008-12-06 | 2012-05-17 | イントラ−セルラー・セラピーズ・インコーポレイテッド | Organic compounds |
JP2012510996A (en) * | 2008-12-06 | 2012-05-17 | イントラ−セルラー・セラピーズ・インコーポレイテッド | Organic compounds |
JP2012510991A (en) * | 2008-12-06 | 2012-05-17 | イントラ−セルラー・セラピーズ・インコーポレイテッド | Organic compounds |
US9487527B2 (en) | 2008-12-06 | 2016-11-08 | Intra-Cellular Therapies, Inc. | Pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione derivatives useful as inhibitors of phosphodiesterase I |
US11464781B2 (en) | 2009-02-25 | 2022-10-11 | Intra-Cellular Therapies, Inc. | PDE1 inhibitors for ophthalmic disorders |
US9468637B2 (en) | 2009-05-13 | 2016-10-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
US10238660B2 (en) | 2009-05-13 | 2019-03-26 | Intra-Cellular Therapies, Inc. | Organic compounds |
US10010553B2 (en) | 2009-05-13 | 2018-07-03 | Intra-Cellular Therapies, Inc. | Organic compounds |
US9605041B2 (en) | 2009-08-05 | 2017-03-28 | Intra-Cellular Therapies, Inc. | Regulatory proteins and inhibitors |
US9434730B2 (en) | 2010-05-31 | 2016-09-06 | Intra-Cellular Therapies, Inc. | PDE1 inhibitor compounds |
US9556185B2 (en) | 2010-05-31 | 2017-01-31 | Intra-Cellular Therapies, Inc. | Organic compounds |
US9371327B2 (en) | 2010-05-31 | 2016-06-21 | Intra-Cellular Therapies, Inc. | PDE1 inhibitor compounds |
US9763948B2 (en) | 2010-05-31 | 2017-09-19 | Intra-Cellular Therapies, Inc. | PDE1 inhibitory compounds and methods |
US9801882B2 (en) | 2013-02-17 | 2017-10-31 | Intra-Cellular Therapies, Inc. | Phosphodiesterase-1 inhibitors and their use in treatment of cardiovascular diseases |
US10398698B2 (en) | 2013-02-17 | 2019-09-03 | Intra-Cellular Therapies, Inc. | Uses |
US10682355B2 (en) | 2013-03-15 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Uses |
US9545406B2 (en) | 2013-03-15 | 2017-01-17 | Intra-Cellular Therapies, Inc. | Method of treating a CNS injury with a PDE1 inhibitor |
US9598426B2 (en) | 2013-03-15 | 2017-03-21 | Intra-Cellular Therapies, Inc. | Organic compounds |
US11504372B2 (en) | 2013-03-15 | 2022-11-22 | Intra-Cellular Therapies, Inc. | Uses |
US9073936B2 (en) | 2013-03-15 | 2015-07-07 | Intra-Cellular Therapies, Inc. | Organic compounds |
US10183023B2 (en) | 2013-03-15 | 2019-01-22 | Intra-Cellular Therapies, Inc. | Uses |
US9556186B2 (en) | 2013-03-15 | 2017-01-31 | Intra-Cellular Therapies, Inc. | Organic compounds |
US9884872B2 (en) | 2014-06-20 | 2018-02-06 | Intra-Cellular Therapies, Inc. | Organic compounds |
US10285992B2 (en) | 2014-08-07 | 2019-05-14 | Intra-Cellular Therapies, Inc. | Combinations of PDE1 inhibitors and NEP inhibitors and associated methods |
US9546175B2 (en) | 2014-08-07 | 2017-01-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
US11166956B2 (en) | 2014-08-07 | 2021-11-09 | Intra-Cellular Therapies, Inc. | Combinations of PDE1 inhibitors and NEP inhibitors |
US10131671B2 (en) | 2014-08-07 | 2018-11-20 | Intra-Cellular Therapies, Inc. | Organic compounds |
US10150774B2 (en) | 2014-09-17 | 2018-12-11 | Intra-Cellular Therapies, Inc. | Compounds and methods |
US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
US11291666B2 (en) | 2016-09-12 | 2022-04-05 | Intra-Cellular Therapies, Inc. | Uses |
US11759465B2 (en) | 2018-01-31 | 2023-09-19 | Intra-Cellular Therapies, Inc. | Uses |
US11839614B2 (en) | 2018-01-31 | 2023-12-12 | Intra-Cellular Therapies, Inc. | Methods for treating or mitigating cardiotoxicity characterized by inhibition of adenosine A2 signaling and/or adenosine A2 receptor expression |
Also Published As
Publication number | Publication date |
---|---|
JPS6032638B2 (en) | 1985-07-29 |
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