JPS5239653A - Process for preparing antibiotics of 3',4'-dideoxykanamycin b derivati ves - Google Patents

Process for preparing antibiotics of 3',4'-dideoxykanamycin b derivati ves

Info

Publication number
JPS5239653A
JPS5239653A JP50114883A JP11488375A JPS5239653A JP S5239653 A JPS5239653 A JP S5239653A JP 50114883 A JP50114883 A JP 50114883A JP 11488375 A JP11488375 A JP 11488375A JP S5239653 A JPS5239653 A JP S5239653A
Authority
JP
Japan
Prior art keywords
dideoxykanamycin
derivati ves
preparing antibiotics
antibiotics
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP50114883A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5736917B2 (OSRAM
Inventor
Hamao Umezawa
Sumio Umezawa
Shunzo Fukatsu
Masao Seki
Masao Murase
Harutaro Yasuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to JP50114883A priority Critical patent/JPS5239653A/ja
Priority to GB38256/76A priority patent/GB1507118A/en
Priority to DE2641388A priority patent/DE2641388C3/de
Priority to US05/723,832 priority patent/US4091202A/en
Priority to FR7629956A priority patent/FR2325383A1/fr
Publication of JPS5239653A publication Critical patent/JPS5239653A/ja
Publication of JPS5736917B2 publication Critical patent/JPS5736917B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP50114883A 1975-09-25 1975-09-25 Process for preparing antibiotics of 3',4'-dideoxykanamycin b derivati ves Granted JPS5239653A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP50114883A JPS5239653A (en) 1975-09-25 1975-09-25 Process for preparing antibiotics of 3',4'-dideoxykanamycin b derivati ves
GB38256/76A GB1507118A (en) 1975-09-25 1976-09-15 Antibiotic derivatives of 3',4'-dideoxykanamycin b and the preparation thereof
DE2641388A DE2641388C3 (de) 1975-09-25 1976-09-15 3',4'-Didesoxykanamycin B-N-methansulfonsäuren und deren Alkalimetallsalze sowie diese Verbindungen enthaltende pharmazeutische Präparate
US05/723,832 US4091202A (en) 1975-09-25 1976-09-16 N-methanesulfonic acid derivatives of 3',4'-dideoxykanamycin B
FR7629956A FR2325383A1 (fr) 1975-09-25 1976-09-24 Derives antibiotiques nouveaux de la didesoxy-3',4'kanamycine b et procede pour leur preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50114883A JPS5239653A (en) 1975-09-25 1975-09-25 Process for preparing antibiotics of 3',4'-dideoxykanamycin b derivati ves

Publications (2)

Publication Number Publication Date
JPS5239653A true JPS5239653A (en) 1977-03-28
JPS5736917B2 JPS5736917B2 (OSRAM) 1982-08-06

Family

ID=14649050

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50114883A Granted JPS5239653A (en) 1975-09-25 1975-09-25 Process for preparing antibiotics of 3',4'-dideoxykanamycin b derivati ves

Country Status (5)

Country Link
US (1) US4091202A (OSRAM)
JP (1) JPS5239653A (OSRAM)
DE (1) DE2641388C3 (OSRAM)
FR (1) FR2325383A1 (OSRAM)
GB (1) GB1507118A (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5740496A (en) * 1980-08-22 1982-03-06 Microbial Chem Res Found Low toxic derivative of istamycin antibiotic
JPS58128395A (ja) * 1982-01-27 1983-07-30 Microbial Chem Res Found ３−０−デメチルイスタマイシンｂの低毒性誘導体
US4567165A (en) * 1984-05-08 1986-01-28 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai N-Methanesulfonic acid derivatives of 3-demethoxyistamycin B
US6310073B1 (en) * 1998-07-28 2001-10-30 Queen's University At Kingston Methods and compositions to treat glycosaminoglycan-associated molecular interactions
EA017824B1 (ru) 2007-11-21 2013-03-29 Эйкеоджен, Инк. Антибактериальные аналоги аминогликозида
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2599950A (en) * 1947-04-30 1952-06-10 American Cyanamid Co Method of preparing polymyxin
US2931798A (en) * 1956-09-05 1960-04-05 Umezawa Hamao Kanamycin and processes for the preparation thereof
FR1272911A (fr) * 1958-07-23 1961-10-06 Soc Ind Fab Antibiotiques Sifa Procédé de préparation de nouveaux dérivés d'antibiotiques basiques
GB933702A (en) * 1958-12-12 1963-08-08 Sumio Umezawa Process for the production of n-methanesulfonic acid derivatives of kanamycin
GB957433A (en) * 1959-09-08 1964-05-06 Sumio Umezawa Preparation of kanamycin-n,n-dimethane sulphonic acid
GB896774A (en) * 1960-01-29 1962-05-16 Parke Davis & Co Derivatives of paromomycin and methods for their production
GB902992A (en) * 1960-03-18 1962-08-09 Farmaceutici Italia Antibiotic derivatives
US3061515A (en) * 1960-05-09 1962-10-30 Bristol Myers Co Methane sulfonates of telomycins
US3205137A (en) * 1963-03-19 1965-09-07 Warner Lambert Pharmaceutical Bacitracin derivatives
JPS507595B1 (OSRAM) * 1970-07-29 1975-03-27
US3840535A (en) * 1972-08-23 1974-10-08 Bristol Myers Co Dimethanesulfonates of certain 7-(o-aminomethylphenylacetamido)-3-((heterocyclylthio)methyl)-ceph-3-em-4-carboxylic acids
US4001208A (en) * 1972-10-06 1977-01-04 Zaidan Hojin Biseibutsu Kagaku Kenkyo Kai 1-N-[(S)-α-hydroxy-ω-aminoacyl]

Also Published As

Publication number Publication date
DE2641388C3 (de) 1981-02-05
FR2325383A1 (fr) 1977-04-22
US4091202A (en) 1978-05-23
DE2641388B2 (de) 1980-05-29
JPS5736917B2 (OSRAM) 1982-08-06
FR2325383B1 (OSRAM) 1980-09-26
GB1507118A (en) 1978-04-12
DE2641388A1 (de) 1977-03-31

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