JPH1199192A - Radioactive drug container and radioactive drug preparation with this container - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prevent the adsorption of a radioactive drug having a high adsorption property and to make the display of a stored object and a stored quantity conspicuous by covering the inner surface of a glass container with silica, and displaying back characters on the surface of the glass container. SOLUTION: A thermal volatile silicon compound is put as a simple substance or is dissolved in a solvent 6 such as alcohol in a glass container 5 filled with a normal drug, and the inner surface of the container 5 is covered with silica by a heat treatment to obtain this radioactive drug container. Silyltetraisocyanate, silane gas, or a silicon halogen compound is used for the thermal volatile silicon compound. A silica thin film prevents the contact between a water-soluble component such as alkali contained in glass and a drug. Back characters are displayed on the side opposite to the observation side of the transparent container by directly printing the back characters on the surface of the transparent container or by sticking a transparent label printed with the back characters to a transparent vial.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a pharmaceutical container for filling a radiopharmaceutical, and more particularly, to a pharmaceutical container for filling, transporting, and storing a radiopharmaceutical such as radioactive thallium chloride, and a display of contents. And a pharmaceutical container printed thereon so as to facilitate its confirmation.

[0002]

2. Description of the Related Art A radioactive substance is sometimes used as a tracer for image diagnosis in a medical field. When the element is used alone as a radioactive substance, or when a compound showing a specific behavior in a living body is used after being labeled. There are cases.

A radioactive substance administered orally by a capsule or the like or intravenously by an injection shows a distribution specific to the substance in a living body, and the distribution is determined from outside the body using a scintillation camera or a gamma camera. Is detected. The two-dimensional arrangement of the detected radioactivity is determined, and the amount of distribution is measured. The radioactivity distribution in the living body is imaged by color-coding the distribution of the radioactivity by computer processing. At present, it is possible to perform an image diagnosis of a myocardial lesion or an image diagnosis of a tumor by using such a technique.

[0004] Examples of the radioactive substance and its tracer used in the above diagnosis include radioactive thallium chloride, radioactive iodine, radioactive technetium and the like. Since these radioactive substances are generally administered as injections, they are provided in glass vials or in syringe-type containers, but in these containers, a predetermined amount of radioactive substance is correctly administered to the patient. In order to do so, an accurate amount of display is required.

However, sometimes a radiopharmaceutical, for example, radioactive thallium chloride ( ²⁰¹ Tl), exhibits an adsorptive property in a container. In such a case, even if an accurate amount is measured, a predetermined amount of the radioactive substance is removed. There was a problem that it could not be administered to patients. Also, in the case of pharmaceutical containers, it is common to display the contents and content by printing directly on the surface of the container, but in the case of radiopharmaceutical containers, in order to reduce the radiation exposure of the operator, in many cases, Since it is stored in a lead shielding container fitted with small lead glass, there is a problem that it is difficult to see the contents and the contents of the container.

[0006] Regarding the problem of the adsorption of the radiopharmaceutical to the pharmaceutical container as described above, use of a plastic container (described in JP-A-8-23829) or addition of a reducing agent (described in JP-A-6-256223). ) Has been reported. As for the method of displaying the contents and the contents, a device has been devised to make it easier to read by using a bright color paint, making the characters thicker or larger.

However, glass containers are sometimes easier to use than plastic containers, and the use of reducing agents that are not directly related to treatment and diagnosis is not very desirable. Furthermore, when a bright color paint is used, it is difficult to confirm the actual contents, and when a method such as enlarging the character is used, the character protrudes from the small lead glass and becomes difficult to read. There was a problem.

[0008]

Therefore, even when a radiopharmaceutical having a high adsorptivity is filled, the adsorption can be prevented.
In addition, there has been a demand for the development of a pharmaceutical container in which the contents and contents can be easily displayed.

[0009]

The present inventor has conducted intensive studies to solve the above-mentioned problems, and as a result, the glass container coated with silica on the inner surface adsorbs radioactive thallium chloride ( ²⁰¹ Tl) on the glass surface. And found that it can be used as a container for radioactive thallium chloride injection.

[0010] In addition, if the display of contents, contents, and the like is displayed in reverse letters on the outside of the medicine container, characters are enlarged by the lens effect of the filled aqueous solution, which makes the characters easy to see. I found that some characters could be read.

That is, the present invention provides a radiopharmaceutical container in which the inner surface of a glass container is coated with silica. The present invention also provides a container for radiopharmaceuticals, wherein a backside is displayed on the surface of the glass container. Further, the present invention provides a radiopharmaceutical preparation in which the above radiopharmaceutical container is filled with a radioactive substance having adsorptivity.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION A radiopharmaceutical container (hereinafter, referred to as a "first container") in which the inner surface of a glass container is coated with silica according to the present invention is a glass container filled with a usual pharmaceutical, for example, a vial. It is prepared by putting a thermally volatile silicone compound alone or in a solution of alcohol or the like inside an ampoule, syringe for injection or the like and subjecting it to heat treatment. Examples of the thermally volatile silicone compound include silyl tetraisocyanate, silane gas, alkyl silane, silane alkoxide, and silicon halide. A specific method for coating the inner surface of a glass container with silica is described in, for example,
No. 175630. In addition,
A glass container whose inner surface is coated with silica is commercially available under a trade name such as Siricoat (manufactured by Fuji Glass Co., Ltd.), and may be used.

In the first container, a thin film of silica covering the inner surface of the glass container serves to prevent contact between a water-soluble component such as alkali contained in the glass and a chemical solution. That is, the glass contains alkali components such as sodium ions (Na ⁺ ) and potassium ions (K ⁺ ), and these components may dissolve into the chemical solution at some time. This dissolved state is considered to be a state in which the equilibrium reaction between the potassium ion and the glass is maintained, and a certain amount of potassium ion is always present in the liquid, but the potassium ion itself is free. Between the state of glass and the state of bonding with glass.

By the way, when an aqueous solution containing radioactive thallium chloride ( ²⁰¹ Tl) is used as a radiopharmaceutical, thallium is present not as trivalent but as monovalent cation, so that thallium is similar to potassium, which is monovalent cation. It is considered to exhibit properties. Then, as a result of thallium ions exhibiting properties similar to potassium ions, a situation arises in which potassium ions and thallium ions competitively react with glass. As a result, a constant amount of thallium is always adsorbed on the glass. That is, even if an accurate amount of a radiopharmaceutical is administered to a patient, the amount of thallium is reduced by the amount absorbed, so that a predetermined amount of the radioactive substance cannot be correctly administered to the patient.

However, when the inner surface of the glass container is coated with silica, dissolution of potassium from the glass is suppressed,
As a result, there is no equilibrium reaction between thallium and potassium, and no thallium adsorption occurs.

Further, a radiopharmaceutical container (hereinafter, referred to as a "second container") having an inverted letter on the surface of the glass container of the present invention.
) Is on the opposite side of the transparent container
This is the display of the back letter. Note that, in this specification, the back letters are those that can be read as normal characters from the opposite side of the displayed surface of the container, and can be read as inverted characters from the displayed surface.

This second container can also be obtained by directly printing back letters on the surface of a transparent container. It can also be obtained by printing back letters on a transparent label and attaching it to a transparent vial. Even if normal characters are printed on the transparent label, the same effect can be obtained by applying an adhesive to the printing surface and attaching the adhesive to a glass vial. Further, the same effect can be obtained by printing normal characters on an opaque label, applying an adhesive to the printed surface, and attaching the adhesive to a glass vial. By displaying in this manner, it is possible to read from the side opposite to the printing.

According to the second container, the refraction of light in the container filled with the liquid can be used to make small characters large so that they can be easily read and at the same time the contents can be easily checked. In order to prevent exposure to radiation, such as radioactive substances, avoid direct observation with the naked eye.When observing through the lead glass of a protective container for radiopharmaceuticals, etc. Can be read only when the window coincides with the window. However, what is printed in the back letters can be read widely by changing the viewing angle, and the characters are enlarged by the lens effect to make it easier to read.

The effect of the second container will be specifically described with reference to the drawings as follows. FIG. 1 is a front view of a radiopharmaceutical protective container, and FIG. 2 is a cross-sectional view taken along the line AA ′ of FIG. 1, wherein 1 is a radiopharmaceutical protective container, 2 is a radiopharmaceutical protective container body, and 3 is a radiopharmaceutical protective container. The container lid 4 is lead glass, 5 is a glass container, and 6 is a liquid agent. Among them, 2 and 3 are metal for exposure prevention,
Generally, it is made of lead, and it is not possible to read the inside 5 and the characters displayed thereon from this part. On the other hand, since 4 is lead glass, it is possible to read the inside 5 and the characters displayed thereon from here.

FIG. 3 is a drawing showing the readable range of each character. That is, when a normal character is displayed at 5, only when this character portion matches 4, that is, a character in the range indicated by a can be read.
On the other hand, when the back letter is displayed at 5, even in the range of a described above, the back letter is difficult to read, but if 5 is filled with a transparent liquid material, the opposite side (diagonal line) is caused by the lens effect. The characters on the side) are large and can be read as ordinary characters. By changing the viewing angle for 4, a wide range of characters, that is, a range of characters indicated by b on the opposite side can be read.

[0021]

According to the first container of the present invention, when a container for radiopharmaceuticals, especially a container for pharmaceuticals for radioactive thallium chloride, a precise amount of radioactive substance is administered by collecting a predetermined amount. Becomes possible.

Further, according to the second container of the present invention, even when viewing through lead glass, the back letter printed on the glass container is small due to the contents and the lens effect generated by the container itself. Even through a window, the image can be read in a wide range by being enlarged and changing the viewing angle, so that it is possible to easily read the image.

[0023]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples.

EXAMPLE 1 Vial for radioactive thallium chloride: JP-A-2-17563
According to the method disclosed in the example of No. 0, the inner surfaces of 15 glass vials were coated with silica to obtain the vials of the present invention. For comparison, 15 glass vials without silica coating were used (comparative vials). Each vial was filled with 1 ml of a radioactive thallium chloride ( ²⁰¹ Tl) injection solution (manufactured by Daiichi Radioisotope Laboratories) and allowed to stand at room temperature for a predetermined time to adsorb thallium on the glass wall.
Thereafter, the solution was discarded, and further washed with 1 ml of physiological saline for injection. After the washing solution was discarded, the remaining radioactivity of each vial was measured using a semiconductor detector (manufactured by Seiko EG & G). The rate of adsorption of radioactive thallium was calculated from the amount of residual radioactivity relative to the amount of radioactivity charged. Table 1 shows the results.

[0025]

[Table 1]

From the above results, it was found that the adsorption of radioactive thallium chloride on the silica-coated vial of the present invention was extremely small and almost zero compared with the comparative glass vial.

Example 2 Vial for eluting radioactive technetium: Vial for eluting radioactive technetium (Daiichi Radioisotope Co .; 25 mm in diameter; hereinafter referred to as "collecting vial")
Then, a character having a lateral diameter of about 1 mm is displayed in a normal state and a backside state. A vial in which letters were displayed in a normal state was filled with 5 ml of physiological saline, and the vial was placed in a shielding container with lead glass (manufactured by Daiichi Radioisotope Laboratory), and then observed through the lead glass (normal observation). In addition, the vial displaying the back letters was filled with 5 ml of physiological saline, and set on a diagonal line of lead glass, and the contents and characters were observed (diagonal observation). Table 2 shows the results.

[0028]

[Table 2]

As is apparent from these results, by observing the back letters and observing the diagonal line from the lead glass window, the letters can be largely recognized, and the presence of the liquid in the container is determined at the same time. It becomes possible.

Example 3 5 ml glass vial: Small diameter glass vial (diameter 15 mm:
Using Fuji Glass Co., Ltd.), normal characters and back letters were displayed on the surface, and the readability of the characters was tested in the same manner as in Example 2. Table 3 shows the results.

[0031]

[Table 3]

[Brief description of the drawings]

FIG. 1 is a front view of a radiopharmaceutical protective container.

FIG. 2 is a sectional view taken along the line AA ′ of FIG. 1;

FIG. 3 is a view showing a readable range of characters.

[Explanation of symbols]

 1 ... radiopharmaceutical protective container 2 ... radiopharmaceutical protective container main body 3 ... radiopharmaceutical protective container lid 4 ... lead glass 5 ... glass container 6 ... liquid a ... range in which ordinary characters can be read b ... The range in which the back letters can be read

Claims (6)

[Claims] 1. A radiopharmaceutical container, wherein the inner surface of a glass container is coated with silica. 2. A container for radiopharmaceuticals, wherein an inverted letter is displayed on the surface of the glass container. 3. The radiopharmaceutical container according to claim 2, wherein the glass container has a cylindrical shape. 4. A container for radiopharmaceuticals, wherein the inner surface of the glass container is coated with silica, and the backside of the surface of the glass container is displayed. 5. A radiopharmaceutical preparation, characterized in that a radiopharmaceutical container in which an inner surface of a glass container is coated with silica is filled with a radioactive substance having adsorptivity. 6. The radiopharmaceutical preparation according to claim 5, wherein the radioactive substance having adsorptivity is thallium chloride.