JPH11510490A - ルイスｙエピトープの複合糖質の合成及びこれらの使用 - Google Patents

ルイスｙエピトープの複合糖質の合成及びこれらの使用

Info

Publication number
JPH11510490A
JPH11510490A JP9506955A JP50695597A JPH11510490A JP H11510490 A JPH11510490 A JP H11510490A JP 9506955 A JP9506955 A JP 9506955A JP 50695597 A JP50695597 A JP 50695597A JP H11510490 A JPH11510490 A JP H11510490A
Authority
JP
Japan
Prior art keywords
compound
patient
following structure
mmol
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP9506955A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11510490A5 (enExample
Inventor
ダニシェフスキー、サミュエル・ジェイ
ビハー、ビクター
ロイド、ケニス・オー
Original Assignee
スローン−ケタリング・インスティテュート・フォー・キャンサー・リサーチ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by スローン−ケタリング・インスティテュート・フォー・キャンサー・リサーチ filed Critical スローン−ケタリング・インスティテュート・フォー・キャンサー・リサーチ
Publication of JPH11510490A publication Critical patent/JPH11510490A/ja
Publication of JPH11510490A5 publication Critical patent/JPH11510490A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/001171—Gangliosides, e.g. GM2, GD2 or GD3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP9506955A 1995-07-24 1996-07-24 ルイスｙエピトープの複合糖質の合成及びこれらの使用 Ceased JPH11510490A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/506,251 US6303120B1 (en) 1994-03-15 1995-07-24 Synthesis of glycoconjugates of the lewis y epitope and uses thereof
US08/506,251 1995-07-24
PCT/US1996/012115 WO1997003995A1 (en) 1995-07-24 1996-07-24 Synthesis of glycoconjugates of the lewis y epitope and uses thereof

Publications (2)

Publication Number Publication Date
JPH11510490A true JPH11510490A (ja) 1999-09-14
JPH11510490A5 JPH11510490A5 (enExample) 2004-08-26

Family

ID=24013831

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9506955A Ceased JPH11510490A (ja) 1995-07-24 1996-07-24 ルイスｙエピトープの複合糖質の合成及びこれらの使用

Country Status (6)

Country Link
US (2) US6303120B1 (enExample)
EP (1) EP0854878A4 (enExample)
JP (1) JPH11510490A (enExample)
AU (1) AU725715B2 (enExample)
CA (1) CA2227592A1 (enExample)
WO (1) WO1997003995A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013528211A (ja) * 2010-06-11 2013-07-08 イムノボ ビー．ブイ． 三糖誘導体及びアジュバントとしてのその使用

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303120B1 (en) 1994-03-15 2001-10-16 Memorial Sloan-Kettering Institute For Cancer Research Synthesis of glycoconjugates of the lewis y epitope and uses thereof
US5932553A (en) 1996-07-18 1999-08-03 The Regents Of The University Of California Illudin analogs useful as antitumor agents
US5723632A (en) 1996-08-08 1998-03-03 Mgi Pharma, Inc. Total synthesis of antitumor acylfulvenes
AU750701C (en) 1997-04-16 2003-03-20 Sloan-Kettering Institute For Cancer Research Alpha-O-linked glycoconjugates, methods of preparation and uses thereof
US7550146B2 (en) 1997-04-16 2009-06-23 Sloan-Kettering Institute For Cancer Research Glycopeptide conjugates and uses thereof
ATE307208T1 (de) * 1997-07-11 2005-11-15 Us Gov Health & Human Serv Pseudomonas exotoxin-a-ähnliche chimerische immunogene
US20030054012A1 (en) * 2000-05-12 2003-03-20 Fitzgerald David J. Pseudomonas exotoxin a-like chimeric immunogens for eliciting a secretory iga-mediated immune response
US7314632B1 (en) * 1997-07-11 2008-01-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pseudomonas exotoxin A-like chimeric immunogens
US6025328A (en) 1998-02-20 2000-02-15 The Regents Of The University Of California Antitumor agents
US7141603B2 (en) 1999-02-19 2006-11-28 The Regents Of The University California Antitumor agents
AU758097B2 (en) * 1998-03-25 2003-03-13 Sloan-Kettering Institute For Cancer Research Trimeric antigenic O-linked glycopeptide conjugates, methods of preparation and uses thereof
CA2697598A1 (en) 1999-01-12 2000-07-20 Cambridge Enterprise Limited Compounds and methods to inhibit or augment an inflammatory response
US6551998B1 (en) 1999-06-22 2003-04-22 University Of Louisville Research Foundation, Inc. Antimicrobial agents
US7854934B2 (en) 1999-08-20 2010-12-21 Sloan-Kettering Institute For Cancer Research Glycoconjugates, glycoamino acids, intermediates thereto, and uses thereof
WO2001014395A2 (en) 1999-08-20 2001-03-01 Sloan-Kettering Institute For Cancer Research Novel glycoconjugates, glycoamino, acids, intermediates thereto, and uses thereof
US7824687B2 (en) 1999-08-20 2010-11-02 Sloan-Kettering Institute For Cancer Research Clustered multi-antigenic carbohydrate constructs, methods for their preparation, and uses thereof
WO2002026762A1 (en) 2000-09-29 2002-04-04 Regents Of The University Of Minnesota Triterpenes having antibacterial activity
US6951847B2 (en) 2000-09-29 2005-10-04 Regents Of The University Of Minnesota Methods of treating fungal infections using lupeol
AU2001294953A1 (en) 2000-09-29 2002-04-08 Regents Of The University Of Minnesota Triterpenes having fungicidal activity against yeast
US7335359B2 (en) * 2003-02-06 2008-02-26 Tripep Ab Glycosylated specificity exchangers
WO2004069873A2 (en) 2003-02-06 2004-08-19 Tripep Ab Antigen/antibody or ligand/receptor glycosylated specificity exchangers
JP4989648B2 (ja) 2005-08-03 2012-08-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 抗癌剤として有用なイルジン類似体
WO2007051004A2 (en) * 2005-10-28 2007-05-03 The Brigham And Women's Hospital, Inc. Conjugate vaccines for non-proteinaceous antigens
WO2010002478A2 (en) * 2008-07-03 2010-01-07 University Of Georgia Research Foundation, Inc. Glycopeptide and uses thereof
WO2007079448A2 (en) * 2006-01-03 2007-07-12 University Of Georgia Research Foundation, Inc. Three component carbohydrate vaccine
US20090092631A1 (en) * 2007-03-26 2009-04-09 Tripep Ab Glycosylated specificity exchangers that induce an antibody dependent cellular cytotoxicity (adcc) response
US8624006B2 (en) 2007-04-09 2014-01-07 The Regents Of The University Of California One-pot synthesis of alpha/beta-O-glycolipids
US20100324469A1 (en) * 2007-10-04 2010-12-23 Josai University Corporation Drug product, a method of administrating a vaccine using the drug product, and an apparatus for iontophoresis
WO2009132082A2 (en) * 2008-04-22 2009-10-29 Medical College Of Georgia Research Institute, Inc. Immunogenic compositions containing ceramide and methods of use thereof
WO2010006343A2 (en) * 2008-07-11 2010-01-14 Sloan-Kettering Institute For Cancer Research Glycopeptide constructs and uses thereof
US20100231101A1 (en) * 2009-02-23 2010-09-16 Richard Rubin Portable casing for housing video production equipment
CN103108654A (zh) 2010-06-11 2013-05-15 索隆-基特林癌症研究协会 多价糖肽构建体及其用途
KR20250145702A (ko) 2017-04-11 2025-10-13 아뷰터스 바이오파마 코포레이션 표적화 조성물
US20220305107A1 (en) 2019-06-18 2022-09-29 Janssen Sciences Ireland Unlimited Company COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND HBV-TARGETING RNAi
US11524026B2 (en) 2019-12-09 2022-12-13 Wayne State University Heparanase inhibitors for treatment of diabetes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4119472A1 (de) * 1991-06-13 1992-12-17 Merck Patent Gmbh Verfahren zur stereoselektiven herstellung von gal-(alpha)(1-3)/gal-(beta)(1-4)/glcnac-trisacchariden und von neuen (beta)(1-3)-verknuepften oligolactosaminen ueber neue partiell alkylierte glykale
WO1993005803A1 (en) * 1991-09-25 1993-04-01 Genetics Institute, Inc. Anti-inflammatory selectin inhibitors
US5622929A (en) * 1992-01-23 1997-04-22 Bristol-Myers Squibb Company Thioether conjugates
US5543505A (en) 1993-03-15 1996-08-06 Sloan-Kettering Institute For Cancer Research Synthetic compounds which bind to H. pylori, and uses thereof
AU2100595A (en) * 1994-03-15 1995-10-03 Sloan-Kettering Institute For Cancer Research Synthetic compounds which bind to (h. pylori), and uses thereof
US5708163A (en) 1994-03-15 1998-01-13 Sloan-Kettering Institute Of Cancer Research Synthesis of the breast tumor-associated antigen defined by monoclonalantibody MBRL and uses thereof
US6303120B1 (en) 1994-03-15 2001-10-16 Memorial Sloan-Kettering Institute For Cancer Research Synthesis of glycoconjugates of the lewis y epitope and uses thereof
US5679769A (en) * 1994-03-15 1997-10-21 Sloan-Kettering Institute For Cancer Research Synthesis of asparagine-linked glycopeptides on a polymeric solid support

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013528211A (ja) * 2010-06-11 2013-07-08 イムノボ ビー．ブイ． 三糖誘導体及びアジュバントとしてのその使用

Also Published As

Publication number Publication date
EP0854878A1 (en) 1998-07-29
WO1997003995A1 (en) 1997-02-06
EP0854878A4 (en) 2004-03-24
AU6594196A (en) 1997-02-18
CA2227592A1 (en) 1997-02-06
US6303120B1 (en) 2001-10-16
US6645935B2 (en) 2003-11-11
US20020038017A1 (en) 2002-03-28
AU725715B2 (en) 2000-10-19

Similar Documents

Publication Publication Date Title
JPH11510490A (ja) ルイスｙエピトープの複合糖質の合成及びこれらの使用
JP5484668B2 (ja) モノクローナル抗体ｍｂｒ１によって同定される乳ガン関連抗原の合成及びこれらの使用
AU750701B2 (en) Alpha-O-linked glycoconjugates, methods of preparation and uses thereof
AU758097B2 (en) Trimeric antigenic O-linked glycopeptide conjugates, methods of preparation and uses thereof
US5679769A (en) Synthesis of asparagine-linked glycopeptides on a polymeric solid support
US6544952B1 (en) Synthesis of glycoconjugates of the globo-H epitope and uses thereof
EP1210355B1 (en) Glycoconjugates, glycoamino, acids, intermediates thereto, and uses thereof
AU747899B2 (en) Colon cancer KH-1 and N3 antigens
WO1993023031A9 (en) Multivalent mimetics and peptide mimetics for blocking carbohydrate-dependent cellular interaction and for eliciting anticarbohydrate t-cell response
WO1995025113A1 (en) Synthetic compounds which bind to h. pylori, and uses thereof

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070703

A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20071121

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20080108