JPH1135467A - Liquid medicine compounded with vitamin b1 compounds - Google Patents
Liquid medicine compounded with vitamin b1 compoundsInfo
- Publication number
- JPH1135467A JPH1135467A JP9197164A JP19716497A JPH1135467A JP H1135467 A JPH1135467 A JP H1135467A JP 9197164 A JP9197164 A JP 9197164A JP 19716497 A JP19716497 A JP 19716497A JP H1135467 A JPH1135467 A JP H1135467A
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- weight
- liquid medicine
- acid
- proline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- YDBYJHTYSHBBAU-YFKPBYRVSA-N S-methyl-L-methioninate Chemical compound C[S+](C)CC[C@H](N)C([O-])=O YDBYJHTYSHBBAU-YFKPBYRVSA-N 0.000 description 1
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- 244000228451 Stevia rebaudiana Species 0.000 description 1
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- 239000004376 Sucralose Substances 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
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- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 229930003537 Vitamin B3 Natural products 0.000 description 1
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- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
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- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 229960003121 arginine Drugs 0.000 description 1
- 235000009697 arginine Nutrition 0.000 description 1
- BTNNPSLJPBRMLZ-LGMDPLHJSA-N benfotiamine Chemical compound C=1C=CC=CC=1C(=O)SC(/CCOP(O)(O)=O)=C(/C)N(C=O)CC1=CN=C(C)N=C1N BTNNPSLJPBRMLZ-LGMDPLHJSA-N 0.000 description 1
- 229960002873 benfotiamine Drugs 0.000 description 1
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- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
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- 229960002061 ergocalciferol Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
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- 235000011087 fumaric acid Nutrition 0.000 description 1
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- 229950006836 fursultiamine Drugs 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229960002989 glutamic acid Drugs 0.000 description 1
- 229960002743 glutamine Drugs 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
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- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
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- 229960003512 nicotinic acid Drugs 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
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- 239000011772 phylloquinone Substances 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 description 1
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- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
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- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
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- 229940109850 royal jelly Drugs 0.000 description 1
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 description 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 229960003211 sulbutiamine Drugs 0.000 description 1
- CKHJPWQVLKHBIH-ZDSKVHJSSA-N sulbutiamine Chemical compound C=1N=C(C)N=C(N)C=1CN(C=O)C(/C)=C(/CCOC(=O)C(C)C)SS\C(CCOC(=O)C(C)C)=C(\C)N(C=O)CC1=CN=C(C)N=C1N CKHJPWQVLKHBIH-ZDSKVHJSSA-N 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960001385 thiamine disulfide Drugs 0.000 description 1
- 229960004799 tryptophan Drugs 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000011912 vitamin B7 Nutrition 0.000 description 1
- 239000011735 vitamin B7 Substances 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、ビタミンＢ１類の
安定性を向上させた液剤に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid preparation having improved stability of vitamin B1.
【０００２】[0002]
【従来の技術】ビタミンＢ１類は様々な薬効が知られ、
医薬品、食品などに広く配合されている。2. Description of the Related Art Vitamin B1 is known for its various medicinal effects.
Widely used in pharmaceuticals and foods.
【０００３】しかし、ビタミンＢ１類は、液剤に配合し
た場合の安定性が必ずしも満足できるものではない。そ
のため、液剤にビタミンＢ１類を配合するには、必要配
合量よりも過剰量を配合する必要がある。ここで、製品
化後のビタミンＢ１類の残存率が数％でも向上すれば、
液剤の品質保持の点で非常に有効である。[0003] However, the stability of vitamin B1 when blended in a liquid preparation is not always satisfactory. Therefore, in order to mix vitamin B1 in the liquid preparation, it is necessary to mix an excess amount from the required mixing amount. Here, if the residual rate of vitamin B1 after commercialization is improved by several percent,
It is very effective in maintaining the quality of the solution.
【０００４】従来、液剤中でのビタミンＢ１類の安定性
を、十分向上させる方法は知られていない。[0004] Heretofore, there has been no known method for sufficiently improving the stability of vitamin B1 in a liquid preparation.
【０００５】[0005]
【発明が解決しようとする課題】本発明は、ビタミンＢ
１類が安定化された液剤の提供を目的とする。SUMMARY OF THE INVENTION The present invention relates to vitamin B
One object is to provide a stabilized liquid preparation.
【０００６】[0006]
【課題を解決するための手段】本発明者らは鋭意研究し
た結果、ビタミンＢ１類を配合した液剤に、アラニン、
リジンおよびプロリンを配合すると、ビタミンＢ１類の
安定性が大幅に向上することを見出し、本発明を完成し
た。Means for Solving the Problems As a result of intensive studies, the present inventors have found that alanine, alanine,
It has been found that the addition of lysine and proline greatly improves the stability of vitamin B1s, and thus completed the present invention.
【０００７】すなわち本発明は、ビタミンＢ１類、アラ
ニン、リジンおよびプロリンを配合したことを特徴とす
る液剤である。[0007] That is, the present invention is a liquid preparation comprising vitamin B1s, alanine, lysine and proline.
【０００８】[0008]
【発明の実施の形態】本発明でビタミンＢ１類とは、具
体的にはチアミン、チアミンジスルフィド、ビスベンチ
アミン、ビスイブチアミン、ジセチアミン、チアミンモ
ノホスフェイトジスルフィド、ベンフォチアミン、シコ
チアミン、オクトチアミン、フルスルチアミン、プロス
ルチアミンなどがあげられ、それらの塩も含まれる。BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, vitamins B1 include thiamine, thiamine disulfide, bisbenthamine, bisibutiamine, dicetiamine, thiamine monophosphate disulfide, benfotiamine, sicotiamine, octothiamine, and the like. Fursultiamine, prosultiamine and the like, and salts thereof are also included.
【０００９】ビタミンＢ１類の安定性向上の点から、本
発明のアラニンの配合量は、ビタミンＢ１類１重量部に
対して０．４〜４５重量部であり、好ましくは４．５〜
４５重量部である。また、リジンの配合量はビタミンＢ
１類１重量部に対して４〜４５０重量部であり、好まし
くは４５〜４５０重量部である。さらに、プロリンの配
合量はビタミンＢ１類１重量部に対して０．５〜５５重
量部であり、好ましくは５〜５５重量部である。From the viewpoint of improving the stability of vitamin B1s, the amount of alanine of the present invention is 0.4 to 45 parts by weight, preferably 4.5 to 45 parts by weight per 1 part by weight of vitamin B1s.
45 parts by weight. The amount of lysine is vitamin B
The amount is 4 to 450 parts by weight, preferably 45 to 450 parts by weight, per 1 part by weight of one class. The amount of proline is 0.5 to 55 parts by weight, preferably 5 to 55 parts by weight, per 1 part by weight of vitamin B1.
【００１０】また、配合するリジンとプロリンの配合比
は、アラニン１重量部に対して、リジンが５〜５０重量
部、プロリンが０．５〜５重量部となる量が好ましい。The mixing ratio of lysine and proline to be mixed is preferably such that 5 to 50 parts by weight of lysine and 0.5 to 5 parts by weight of proline per 1 part by weight of alanine.
【００１１】本発明で用いるアラニン、リジンおよびプ
ロリンは各種の塩を使用することができ、特に塩酸塩の
使用が好ましい。As the alanine, lysine and proline used in the present invention, various salts can be used, and the use of hydrochloride is particularly preferable.
【００１２】本発明の液剤は、ｐＨ２〜６の範囲が好ま
しく、ｐＨ２．８〜４．５の範囲がさらに好ましい。ｐ
Ｈがこの範囲を外れるとビタミンＢ１類の安定性が低下
するからである。The pH of the liquid preparation of the present invention is preferably in the range of 2 to 6, more preferably 2.8 to 4.5. p
If H is out of this range, the stability of vitamin B1 will decrease.
【００１３】ｐＨの調節には、一般的なｐＨ調節剤を使
用することができるが、安定性の点からリン酸を使用す
ることが好ましい。For pH adjustment, a general pH adjuster can be used, but phosphoric acid is preferably used from the viewpoint of stability.
【００１４】本発明では、風味の点から、さらにキシリ
トールまたはエリスリトールを配合することが好まし
い。特にキシリトールおよびエリスリトールの両方を配
合すると、ビタミンＢ１類の安定性の改善の点から特に
好ましい。In the present invention, it is preferable to further add xylitol or erythritol from the viewpoint of flavor. Particularly, it is particularly preferable to mix both xylitol and erythritol from the viewpoint of improving the stability of vitamin B1.
【００１５】キシリトールおよびエリスリトールの配合
量は、風味の点および安定性向上の点から、キシリトー
ル濃度は７〜９Ｗ％が好ましく、エリスリトールの配合
量はキシリトール１重量部に対してエリスリトール１〜
３重量部となる量が好ましい。The amount of xylitol and erythritol is preferably 7 to 9% by weight from the viewpoint of flavor and improvement of stability. The amount of erythritol is 1 to 1 part by weight of erythritol.
An amount of 3 parts by weight is preferred.
【００１６】本発明には、液剤を不快な風味にするメチ
オニン、スレオニン、トリプトファン、グルタミン、グ
ルタミン酸、ロイシン、イソロイシン、バリンなどのア
ミノ酸類を配合することがあることから、服用しやすい
風味にするために、紫蘇様、パイナップル様またはそれ
らを混合した様な香料を配合することが好ましい。According to the present invention, amino acids such as methionine, threonine, tryptophan, glutamine, glutamic acid, leucine, isoleucine, and valine, which make the liquid preparation have an unpleasant flavor, are sometimes mixed. It is preferable to blend a perfume such as Shiso, pineapple or a mixture thereof.
【００１７】本発明の液剤は、さらに、ビタミンＢ１類
の安定性を損ねない範囲で有機酸または無機酸を配合す
ると風味の点で好ましい。そのときの有機酸としてはク
エン酸、リンゴ酸、酒石酸、コハク酸、乳酸、酢酸、マ
レイン酸、グルコン酸、アスパラギン酸、アジピン酸、
グルタミン酸、フマル酸、酢酸、ポリリン酸、グリセロ
リン酸、塩酸、硝酸などをあげることができる。The liquid preparation of the present invention is preferably blended with an organic acid or an inorganic acid in a range that does not impair the stability of vitamin B1s, from the viewpoint of flavor. At that time, citric acid, malic acid, tartaric acid, succinic acid, lactic acid, acetic acid, maleic acid, gluconic acid, aspartic acid, adipic acid,
Glutamic acid, fumaric acid, acetic acid, polyphosphoric acid, glycerophosphoric acid, hydrochloric acid, nitric acid and the like can be mentioned.
【００１８】また、エリスリトール、キシリトール以外
の甘味剤についても、安定性を損ねず、風味を更に向上
する範囲で配合することが好ましい。甘味剤としては、
砂糖、果糖、ブドウ糖、麦芽糖、トレハロース、パラチ
ノース、マルチトール、ソルビトール、パラチニット、
ステビア、ソーマチン、シュクラロースなどがあげられ
る。It is also preferable to add sweeteners other than erythritol and xylitol in a range that does not impair the stability and further improves the flavor. As a sweetener,
Sugar, fructose, glucose, maltose, trehalose, palatinose, maltitol, sorbitol, palatinit,
Stevia, thaumatin, sucralose and the like.
【００１９】本発明の液剤には、上記成分の他、通常液
剤に用いることの可能な成分、例えば、タンパク、ペプ
チド、各種アミノ酸（メチオニン、スレオニン、アスパ
ラギン酸、ヒスチジン、フェニルアラニン、バリン、ロ
イシン、イソロイシン、アルギニン、グリシン、タウリ
ン、カルニチン、グルタミン、グルタミン酸、トリプト
ファン、カルニチン、シスチン、システイン、チロジ
ン、セリンまたはこれらの誘導体など）、各種ビタミン
（ビタミンＢ２、ビタミンＢ３、ビタミン５、ビタミン
Ｂ６、ビタミンＢ１２、ビタミンＣ、ビタミンＡ、ビタ
ミンＤ２、ビタミンＤ３、ビタミンＥ、ビタミンＰ、ビ
タミンＫ１、ビタミンＨ、ビタミンＦ、ビタミンＵな
ど）もしくはビタミン誘導体、ミネラル（カルシウム、
マグネシウム、鉄、カリウムなど）、生薬（ムイラプア
マ、ニンジン、ジオウ、トウチュウカソウなど）、カフ
ェイン、ローヤルゼリー、多価アルコール（プロピレン
グリコールなど）、保存剤、着色料などを配合すること
ができ、液剤製造の通常の方法で製造することができ
る。The liquid preparation of the present invention may contain, in addition to the above-mentioned components, components which can be used in liquid preparations, for example, proteins, peptides, various amino acids (methionine, threonine, aspartic acid, histidine, phenylalanine, valine, leucine, isoleucine). , Arginine, glycine, taurine, carnitine, glutamine, glutamic acid, tryptophan, carnitine, cystine, cysteine, tyrosine, serine or derivatives thereof, various vitamins (vitamin B2, vitamin B3, vitamin 5, vitamin B6, vitamin B12, vitamin B12) C, vitamin A, vitamin D2, vitamin D3, vitamin E, vitamin P, vitamin K1, vitamin H, vitamin F, vitamin U, etc. or vitamin derivatives, minerals (calcium,
Magnesium, iron, potassium, etc.), herbal medicines (mirapuama, carrots, radish, eucalypt, etc.), caffeine, royal jelly, polyhydric alcohols (propylene glycol, etc.), preservatives, coloring agents, etc. It can be manufactured by a usual method.
【００２０】[0020]
【発明の効果】本発明により、ビタミンＢ１類の安定性
を向上させた液剤の提供が可能となった。According to the present invention, it has become possible to provide a liquid preparation with improved stability of vitamin B1.
【００２１】[0021]
【実施例】以下、実施例および試験例をあげて本発明を
さらに詳細に説明する。なお、試験例でのビタミンＢ１
類の残存率はＨＰＬＣを用いた常法により測定した。The present invention will be described below in more detail with reference to examples and test examples. In addition, vitamin B1 in a test example
The residual ratio of the compounds was measured by a conventional method using HPLC.
【００２２】実施例１ Ｌ−ヒスチジン塩酸塩 １０５mg Ｌ−リジン塩酸塩 ２２５mg Ｌ−フェニルアラニン ７６mg Ｌ−スレオニン ７６mg Ｌ−バリン １１５mg Ｌ−ロイシン １４２mg Ｌ−イソロイシン １１５mg Ｌ−メチオニン ７６mg Ｌ−アルギニン塩酸塩 ３００mg Ｌ−アスパラギン酸 ３０mg Ｌ−アラニン ２２mg Ｌ−プロリン ２６mg グリシン ５０mg タウリン １２００mg ＤＬ−塩化カニチン ３０mg ＶＢ２リン酸エステル ３mg ＶＢ６ ５mg ニコチン酸アミド ２０mg ＶＢ１硝酸塩 ５mg エリスリトール ８０００mg キシリトール ４０００mg ＰＶＰ ５００mg カラメル ５０mg 精製水 全５０mL 上記各成分を混合溶解し、リン酸（８５％溶液）でｐＨ
３に調節後８０℃３０分滅菌して、試験溶液を得た。Example 1 L-histidine hydrochloride 105 mg L-lysine hydrochloride 225 mg L-phenylalanine 76 mg L-threonine 76 mg L-valine 115 mg L-leucine 142 mg L-isoleucine 115 mg L-methionine 76 mg L-arginine hydrochloride 300 mg L- Aspartic acid 30 mg L-alanine 22 mg L-proline 26 mg Glycine 50 mg Taurine 1200 mg DL-canitine chloride 30 mg VB2 phosphate 3 mg VB6 5 mg Nicotinamide 20 mg VB1 nitrate 5 mg Erythritol 8000 mg Each of the above-mentioned waters 500 mg Xylitol 4000 mg Dissolve and mix with phosphoric acid (85% solution) to pH
After adjusting to 3, the solution was sterilized at 80 ° C. for 30 minutes to obtain a test solution.
【００２３】実施例２ Ｌ−ヒスチジン塩酸塩 １０５mg Ｌ−リジン塩酸塩 ２２５mg Ｌ−フェニルアラニン ７６mg Ｌ−スレオニン ７６mg Ｌ−バリン １１５mg Ｌ−ロイシン １４２mg Ｌ−イソロイシン １１５mg Ｌ−メチオニン ７６mg Ｌ−アルギニン塩酸塩 ３００mg Ｌ−アスパラギン酸 ３０mg Ｌ−アラニン ２２mg Ｌ−プロリン ２６mg グリシン ５０mg タウリン １２００mg ＤＬ−塩化カニチン ３０mg ＶＢ２リン酸エステル ３mg ＶＢ６ ５mg ニコチン酸アミド ２０mg ＶＢ１硝酸塩 ５mg エリスリトール ８０００mg キシリトール ４０００mg ＰＶＰ ５００mg 紫蘇、パイナップル様香料 微量 カラメル ５０mg 精製水 全５０mL 上記各成分を混合溶解し、リン酸（８５％溶液）でｐＨ
３に調節後８０℃３０分滅菌して、試験溶液を得た。Example 2 L-histidine hydrochloride 105 mg L-lysine hydrochloride 225 mg L-phenylalanine 76 mg L-threonine 76 mg L-valine 115 mg L-leucine 142 mg L-isoleucine 115 mg L-methionine 76 mg L-arginine hydrochloride 300 mg L- Aspartic acid 30 mg L-alanine 22 mg L-proline 26 mg Glycine 50 mg Taurine 1200 mg DL-canitine chloride 30 mg VB2 phosphate 3 mg VB6 5 mg Nicotinamide 20 mg VB1 nitrate 5 mg Erythritol 8000 mg Purified water-like xylitol 4000 mg A total of 50 mL The above components are mixed and dissolved, and phosphoric acid (85% solution) is used
After adjusting to 3, the solution was sterilized at 80 ° C. for 30 minutes to obtain a test solution.
【００２４】比較例１ 実施例１の処方からＬ−アラニン、Ｌ−リジン塩酸塩お
よびＬ−プロリンを除いた処方により、同様にして液剤
を得た。Comparative Example 1 A liquid preparation was obtained in the same manner as in Example 1, except that L-alanine, L-lysine hydrochloride and L-proline were omitted.
【００２５】比較例２ 比較例１と同一の処方で、ｐＨ調節をクエン酸で行った
他は同様にして液剤を得た。Comparative Example 2 A liquid preparation was obtained in the same manner as in Comparative Example 1, except that the pH was adjusted with citric acid.
【００２６】比較例３ 比較例２のエリスリトールおよびキシリトールを砂糖２
１ｇに変更した処方で同様にして液剤を得た。Comparative Example 3 The erythritol and xylitol of Comparative Example 2 were added to sugar 2
A liquid preparation was obtained in the same manner with the prescription changed to 1 g.
【００２７】試験例１ 実施例１および２ならびに比較例１〜３で得られた液剤
を、６５℃に保存して２１日後のビタミンＢ１の残存率
（％）を測定した。結果を表１に示した。Test Example 1 The liquid preparations obtained in Examples 1 and 2 and Comparative Examples 1 to 3 were stored at 65 ° C., and the residual ratio (%) of vitamin B1 after 21 days was measured. The results are shown in Table 1.
【００２８】[0028]
【表１】 [Table 1]
【００２９】試験例から明らかなように、本発明により
ビタミンＢ１類の安定性が向上することがわかった。ま
た、別に行った風味試験により紫蘇およびパイナップル
系香料を配合した液剤（実施例２）は、配合していない
液剤（実施例１）と比較して、アミノ酸類の不快風味が
大幅に改善し、服用のしやすさが向上することもわかっ
た。As is clear from the test examples, it was found that the present invention improves the stability of vitamin B1. In addition, according to a flavor test conducted separately, the liquid formulation containing the perfume and the pineapple-based flavor (Example 2) significantly improved the unpleasant flavor of amino acids as compared with the liquid formulation without the formulation (Example 1), It was also found that the ease of taking was improved.
Claims (6)
びプロリンを配合したことを特徴とする液剤。1. A liquid preparation comprising vitamin B1s, alanine, lysine and proline.
ニンが０．４〜４５重量部、リジンが４〜４５０重量
部、プロリンが０．５〜５５重量部である請求項１記載
の液剤。2. The liquid preparation according to claim 1, wherein alanine is 0.4 to 45 parts by weight, lysine is 4 to 450 parts by weight, and proline is 0.5 to 55 parts by weight based on 1 part by weight of vitamin B1. .
る請求項１または２に記載の液剤。3. The liquid preparation according to claim 1, further comprising phosphoric acid.
ールからなる群の少なくとも１種を配合したことを特徴
とする請求項１〜３のいずれかに記載の液剤。4. The liquid preparation according to claim 1, further comprising at least one member selected from the group consisting of erythritol and xylitol.
トール１重量部に対してエリスリトールが１〜３重量部
である請求項１〜４のいずれかに記載の液剤。5. The liquid preparation according to claim 1, wherein the xylitol concentration is 7 to 9 W%, and the erythritol is 1 to 3 parts by weight based on 1 part by weight of xylitol.
いずれかに記載の液剤。6. The liquid preparation according to claim 1, which has a pH in the range of 2 to 6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9197164A JPH1135467A (en) | 1997-07-23 | 1997-07-23 | Liquid medicine compounded with vitamin b1 compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9197164A JPH1135467A (en) | 1997-07-23 | 1997-07-23 | Liquid medicine compounded with vitamin b1 compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH1135467A true JPH1135467A (en) | 1999-02-09 |
Family
ID=16369853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9197164A Pending JPH1135467A (en) | 1997-07-23 | 1997-07-23 | Liquid medicine compounded with vitamin b1 compounds |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH1135467A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002097141A (en) * | 2000-09-19 | 2002-04-02 | Nikken Chem Co Ltd | Aqueous solution of vitamin b |
-
1997
- 1997-07-23 JP JP9197164A patent/JPH1135467A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002097141A (en) * | 2000-09-19 | 2002-04-02 | Nikken Chem Co Ltd | Aqueous solution of vitamin b |
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